Tchem MLLT3 Protein AF-9

Protein Summary

Description

Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114). Also recognizes and binds histone H3 acetylated at 'Lys-9' (H3K9ac), but with lower affinity than crotonylated histone H3 (PubMed:25417107, PubMed:27105114). In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones (PubMed:27105114, PubMed:27545619).

Uniprot Accession IDs

• P42568
• B1AMQ2
• B2R7B3
• B7Z755
• D3DRJ8
• Q8IVB0

Gene Name

• MLLT3

Ensembl ID

• ENST00000380338
• ENSP00000369695
• ENSG00000171843
• ENST00000630269
• ENSP00000485996

Symbol

• AF9
• YEATS3
• AF9
• YEATS3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
PubMedID	0.93
virus perturbation	0.85
transcription factor binding site profile	0.79
histone modification site profile	0.72

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Protein Af-9

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Protein Af-9

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Protein Af-9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.24   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 261   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.24   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0