Tclin GRIA3 Glutamate receptor 3

Protein Summary

Description

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P42263
• D3DTF1
• Q4VXD5
• Q4VXD6
• Q9HDA0
• Q9HDA1
• Q9HDA2
• Q9P0H1
• GluR-3

Gene Name

• GRIA3

Ensembl ID

• ENST00000541091
• ENSP00000446440
• ENSG00000125675
• ENST00000620443
• ENSP00000478489
• ENST00000622768
• ENSP00000481554

Symbol

• GLUR3
• GLURC
• GLUR3
• GLURC
• GluA3
• MRX94
• GLUR-C
• GLUR-K3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.81
molecular function	0.81
transcription factor perturbation	0.74
protein domain	0.73
ligand (chemical)	0.72

Protein Classes

DTO Classes

Protein / Ion Channel / Glutamate-gated Ion Channel (Gic) Family Of Neurotransmitter Receptors / Gria3 Subfamily / Glutamate Receptor 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.15   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 310   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.15   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5