Tchem STAT5A Signal transducer and activator of transcription 5A

Protein Summary

Description

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Uniprot Accession IDs

• P42229
• Q1KLZ6

Gene Name

• STAT5A

Ensembl ID

• ENST00000345506
• ENSP00000341208
• ENSG00000126561
• ENST00000546010
• ENSP00000443107
• ENST00000590949
• ENSP00000468749

Symbol

• STAT5
• MGF
• STAT5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	1
biological term	0.99
protein domain	0.99
kinase	0.98

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Signal Transducer And Activator Of Transcription 5a

Protein / Nucleic Acid Binding / Signal Transducer And Activator Of Transcription 5a

DTO Classes

Protein / Nucleic Acid Binding / Signal Transducer And Activator Of Transcription 5a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1357.13   (req: < 5)

Gene RIFs: 302   (req: <= 3)

Antibodies: 1597   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1357.13   (req: >= 5)

Gene RIFs: 302   (req: > 3)

Antibodies: 1597   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0