Tbio PPP1R2 Protein phosphatase inhibitor 2

Protein Summary

Description

Inhibitor of protein-phosphatase 1. Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P41236
• IPP-2

Gene Name

• PPP1R2

Ensembl ID

• ENST00000618156
• ENSP00000484580
• ENSG00000184203

Symbol

• IPP2
• IPP2
• IPP-2
• PPP1R2A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
virus perturbation	0.94
kinase	0.84
transcription factor perturbation	0.84
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Phosphatase Inhibitor / Protein Phosphatase Inhibitor 2

DTO Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Phosphatase Inhibitor / Protein Phosphatase Inhibitor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.73   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 301   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.73   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0