Tclin P2RY2 P2Y purinoceptor 2

Protein Summary

Description

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]

Uniprot Accession IDs

• P41231
• B2R9W3
• Q96EM8
• P2Y2

Gene Name

• P2RY2

Ensembl ID

• ENST00000311131
• ENSP00000310305
• ENSG00000175591
• ENST00000393596
• ENSP00000377221
• ENST00000393597
• ENSP00000377222

Symbol

• P2RU1
• P2U
• HP2U
• P2U1
• P2UR
• P2Y2
• P2RU1
• P2Y2R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.75
gene perturbation	0.71
PubMedID	0.71
histone modification site profile	0.69
tissue sample	0.63

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Purinoceptor / P2y Receptor / P2y Purinoceptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 567.15   (req: < 5)

Gene RIFs: 105   (req: <= 3)

Antibodies: 243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 567.15   (req: >= 5)

Gene RIFs: 105   (req: > 3)

Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 71

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4