Property Summary

NCBI Gene PubMed Count 1,346
Grant Count 4,199
R01 Count 2,308
Funding $440,427,686.26
PubMed Score 15277.15
PubTator Score 6432.76

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (76)

Disease Z-score Confidence
Obesity 616 8.495 4.0
Metabolic syndrome X 155 6.803 3.4
diabetes mellitus 1,663 6.796 3.4
Hyperinsulinism 63 5.953 3.0
Anorexia nervosa 59 5.917 3.0
Hypertension 287 5.712 2.9
Hyperglycemia 120 5.696 2.8
Lipodystrophy 32 5.643 2.8
Lipid metabolism disorder 102 5.384 2.7
Fatty liver disease 84 5.268 2.6
Polycystic Ovary Syndrome 332 5.115 2.6
Atherosclerosis 275 4.871 2.4
Cancer 2,346 4.768 2.4
Obstructive sleep apnea 28 4.607 2.3
Amenorrhea 60 4.555 2.3
Osteoporosis 257 4.472 2.2
Kidney disease 396 4.383 2.2
Infertility 163 4.318 2.2
Bulimia nervosa 15 4.315 2.2
Coronary artery disease 240 4.211 2.1
Hypogonadism 70 4.134 2.1
Arthritis 248 3.936 2.0
Liver disease 219 3.881 1.9
Prader-Willi syndrome 45 3.767 1.9
Hypothyroidism 89 3.702 1.9
Hyperandrogenism 32 3.627 1.8
Rabies 19 3.482 1.7
Asthma 349 3.422 1.7
Heart disease 279 3.317 1.7
Schizophrenia 501 3.317 1.7
Cerebrovascular disease 231 3.288 1.6
Hyperthyroidism 50 3.254 1.6
Anovulation 20 3.251 1.6
Klinefelter's syndrome 59 3.212 1.6
Mood disorder 10 3.05 1.5
Acanthosis nigricans 14 3.038 1.5
Alzheimer's disease 644
Arthritis, Experimental 39
Atopic dermatitis 944
Autistic Disorder 320
Colonic Neoplasms 126
Crohn Disease 97
Diabetes Mellitus, Non-Insulin-Dependent 157
Fatty Liver 48
Female infertility 28
Gastric ulcer 34
Gestational Diabetes 17
Hepatitis, Autoimmune 17
Heroin dependence 30
Hypercholesterolemia 27
Hyperphagia 4
Hypertensive disease 193
Inflammation 109
Insulin Resistance 48
LEPTIN DEFICIENCY OR DYSFUNCTION 1
Liver Cirrhosis, Experimental 108
Mammary Neoplasms 410
Nerve Degeneration 73
Non-alcoholic Fatty Liver Disease 40
Obesity, Morbid 6
Oral Ulcer 2
Polydipsia 1
Polyuria 6
Prostatic Neoplasms 471
Proteinuria 63
Seizures 95
Tachycardia 17
Weight Gain 87
autosomal dominant Emery-Dreifuss muscul... 499 
breast carcinoma 1,614
ductal carcinoma in situ 1,745
facioscapulohumeral dystrophy 286
fibroadenoma 557
invasive ductal carcinoma 2,950
ovarian cancer 8,484
psoriasis 6,685

Expression

  Differential Expression (9)

Disease log2 FC p
psoriasis -1.600 0.000
autosomal dominant Emery-Dreifuss muscul... 1.477 0.010
Atopic dermatitis -2.000 0.011
breast carcinoma -2.600 0.000
fibroadenoma -3.700 0.026
ductal carcinoma in situ -5.000 0.001
invasive ductal carcinoma -6.300 0.000
ovarian cancer -1.800 0.000
facioscapulohumeral dystrophy -1.800 0.049

Synonym

Accession P41159 O15158 Q56A88
Symbols OB
OBS
LEPD

Gene

LEP