Tchem OPRL1 Nociceptin receptor

Protein Summary

Description

G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

Uniprot Accession IDs

• P41146
• Q8TD34
• Q8WYH9
• Q9H4K4

Gene Name

• OPRL1

Ensembl ID

• ENST00000336866
• ENSP00000336843
• ENSG00000125510
• ENST00000349451
• ENSP00000336764
• ENST00000355631
• ENSP00000347848

Symbol

• OOR
• ORL1
• NOP
• OOR
• NOPr
• ORL1
• KOR-3
• NOCIR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.74
co-expressed gene	0.72
ligand (chemical)	0.68
kinase perturbation	0.66
transcription factor	0.66

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Nociceptin Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Nociceptin Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.2   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 203   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.2   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1059

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2