Tclin Delta-type opioid receptor

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G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

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Property Summary

Ligand Count	1,612
NCBI Gene PubMed Count	114
PubMed Score	103.91

PubTator Score	83.55

Knowledge Summary

Patent (2,943)

TINX Plot

Disease (8)

Disease	Target Count	Z-score	Confidence
Epilepsy	792	0.0	0.0
Hypotension, Orthostatic	18	0.0	0.0
Substance Withdrawal Syndrome	55	0.0	0.0
Substance-Related Disorders	115	0.0	0.0

Disease	Target Count
Cocaine Dependence	51
Alcoholic Intoxication, Chronic	289
Nonorganic psychosis	84
Psychotic Disorders	151

Disease	Target Count
Alcoholism	45
Anxiety due to Cardiac Asthma	3
Chronic Pain with Opioid Tolerance	5
Chronic pain	9
General anesthesia	53
Irritable bowel syndrome with diarrhea	3
Labor pain	4
Local anesthesia	40
Obesity	678
Opiate-Induced Respiratory Depression	4
Pain	103
Poisoning by opiate analgesic drug	4
Prevention of opioid abuse	5
Severe Pain with Opioid Tolerance	3
Severe pain	11
Therapeutic opioid induced constipation	3

Disease	Target Count	P-value
atypical teratoid / rhabdoid tumor	5112	2.4e-06
Astrocytoma, Pilocytic	3081	7.9e-04
ependymoma	4679	1.0e-03
astrocytic glioma	2597	1.1e-03
oligodendroglioma	2850	1.4e-03
primitive neuroectodermal tumor	3035	4.2e-03
group 4 medulloblastoma	1855	2.8e-02

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.6

Disease	Target Count	Z-score	Confidence
Motor neuron disease	49	0.0	0.7

Disease	Target Count	Z-score	Confidence
Opiate dependence	29	0.0	5.0

Disease	Target Count	Z-score	Confidence
Heroin dependence	30	4.84	2.4
Alcohol dependence	107	3.918	2.0
Neonatal abstinence syndrome	11	3.838	1.9
Eating disorder	26	3.442	1.7
Neurodegeneration with brain iron accumulation 5	9	3.199	1.6

Differential Expression (7)

Disease	log2 FC	p
astrocytic glioma	-1.800	1.1e-03
Astrocytoma, Pilocytic	-1.400	7.9e-04
atypical teratoid / rhabdoid tumor	-2.000	2.4e-06
ependymoma	-1.900	1.0e-03
group 4 medulloblastoma	-1.300	2.8e-02
oligodendroglioma	-1.700	1.4e-03
primitive neuroectodermal tumor	-1.900	4.2e-03

Brain - Frontal Cortex (BA9) 18,069

Brain - Cortex 18,039

Brain - Anterior cingulate cortex (BA24) 17,989

Brain - Nucleus accumbens (basal ganglia... 18,024

Brain - Caudate (basal ganglia) 18,001

Brain - Putamen (basal ganglia) 17,863

Brain - Amygdala 18,006

Brain - Hippocampus 18,011

Brain - Hypothalamus 18,169

Testis 18,518

Colon - Transverse 17,825

Esophagus - Muscularis 18,017

Cells - Transformed fibroblasts 17,577

Colon - Sigmoid 18,089

Artery - Aorta 17,896

Stomach 17,879

Adipose - Subcutaneous 18,110

Breast - Mammary Tissue 18,103

Brain - Cerebellum 17,983

Vagina 17,834

Skin - Not Sun Exposed (Suprapubic) 18,081

Brain - Cerebellar Hemisphere 18,015

Nerve - Tibial 18,007

Pituitary 18,147

Small Intestine - Terminal Ileum 17,954

Lung 18,057

Liver 18,071

Whole Blood 17,439

Muscle - Skeletal 17,778

Cells - EBV-transformed lymphocytes 18,186

Thyroid 18,024

Adrenal Gland 18,071

Brain - Substantia nigra 17,981

Heart - Left Ventricle 18,006

Ovary 17,971

Esophagus - Mucosa 18,076

Esophagus - Gastroesophageal Junction 18,000

Spleen 17,614

Adipose - Visceral (Omentum) 17,937

Pancreas 18,123

Artery - Coronary 17,949

Brain - Spinal cord (cervical c-1) 17,973

Heart - Atrial Appendage 17,896

adipose tissue 15,837

adrenal gland 15,963

appendix 16,247

bone marrow 14,571

breast 16,063

cerebral cortex 16,630

colon 15,959

duodenum 15,975

endometrium 16,349

epididymis 15,863

fallopian tube 16,245

gallbladder 16,333

kidney 15,917

lung 16,312

lymph node 15,833

ovary 15,408

placenta 15,937

prostate 16,460

rectum 15,705

salivary gland 14,981

skeletal muscle 14,011

skin 16,206

small intestine 16,154

smooth muscle 15,857

spleen 15,972

stomach 16,099

testis 17,936

thyroid gland 15,959

urinary bladder 15,814

Liver and Pancreas 16,750

Digestive Tract 17,369

Urinary Tract 16,678

Endocrine System 18,159

Blood and immune system 16,909

Respiratory system 16,393

Female tissues 17,400

Male tissues 17,142

Skin and soft tissues 17,230

Nervous System 16,725

Cerebral cortex 159

Kidney 1,299

Corpus striatum 5

See source...

Synonym

Accession	P41143 B5B0B8 D-OR-1
Symbols	OPRD

Gene

OPRD1

PANTHER Protein Class (2)

receptor 400

G-protein coupled receptor 221

Ortholog (10)

Species	Source	Disease
Mouse 16,570	Inparanoid OMA EggNOG
Macaque 12,761	Inparanoid OMA EggNOG
Dog 15,073	Inparanoid OMA EggNOG
Rat 15,117	Inparanoid OMA EggNOG
Cow 15,320	OMA EggNOG
Horse 14,252	Inparanoid OMA EggNOG
Opossum 12,230	Inparanoid OMA EggNOG
Pig 10,168	Inparanoid OMA EggNOG
Anole lizard 10,588	Inparanoid OMA
Chimp 14,140	OMA EggNOG

UniProt Keyword (16)

Complete proteome 20,231

Polymorphism 12,194

Reference proteome 20,231

Ubl conjugation 2,439

Cell membrane 3,390

Disulfide bond 3,599

G-protein coupled receptor 830

Glycoprotein 4,623

Membrane 7,361

Receptor 1,502

See all...

GO Function (3)

neuropeptide binding 20

opioid receptor activity 6

enkephalin receptor activity 1

GO Component (10)

cytoplasm 4,094

plasma membrane 4,414

integral component of plasma membrane 1,418

membrane raft 215

neuron projection 235

postsynaptic membrane 210

vesicle 134

intrinsic component of plasma membrane 27

axon terminus 51

dendrite membrane 14

GO Process (22)

adenylate cyclase-inhibiting G-protein c... 45

chemical synaptic transmission 219

G-protein coupled receptor signaling pat... 1,053

G-protein coupled receptor signaling pat... 45

immune response 426

sensory perception of pain 53

neuropeptide signaling pathway 81

phospholipase C-activating G-protein cou... 64

cellular response to growth factor stimu... 45

positive regulation of peptidyl-serine p... 84

See all...

Compartment GO Term (22)

Cell 16,178

Cell part 16,177

Cell periphery 5,382

Cell projection 1,541

Efflux pump complex 35

G-protein coupled receptor heterodimeric... 6

G-protein coupled receptor homodimeric c... 5

Integral component of membrane 5,331

Integral component of plasma membrane 1,693

Intrinsic component of membrane 5,458

Intrinsic component of plasma membrane 1,749

Membrane 8,531

Membrane part 6,554

Mitochondrial inner membrane peptidase c... 41

Neuron part 970

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MGI Phenotype (4)

integument phenotype 1,874

homeostasis-metabolism phenotype 4,747

nervous system phenotype 3,447

behavior-neurological phenotype 3,401

GWAS Trait (1)

Schizophrenia 533

HCA RNA Cell Line (56)

A-431 16,131

A549 15,174

AF22 16,160

AN3-CA 15,648

ASC TERT1 14,842

BEWO 16,726

BJ 15,448

BJ hTERT+ 15,353

BJ hTERT+ SV40 Large T+ 15,609

BJ hTERT+ SV40 Large T+ RasG12V 15,493

See all...

Pathway (21)

Neuroactive ligand-receptor interaction 276

cGMP-PKG signaling pathway 162

Sphingolipid signaling pathway 118

http://identifiers.org/panther.pathway/P... 149

http://identifiers.org/panther.pathway/P... 118

http://identifiers.org/panther.pathway/P... 33

http://identifiers.org/panther.pathway/P... 30

Signal Transduction 2,657

Class A/1 (Rhodopsin-like receptors) 322

See all...

PDB (5)

...
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Drug (10)

oxymorphone
pKi 7.30

naltrexone
pKi 7.02

naloxone
pKi 7.12

morphine
pKi 7.24

hydromorphone
pKi 7.42

nalmefene
pKi 7.88

alvimopan
pKi 7.92

butorphanol
pKi 7.92

tramadol
pKi 8.03

buprenorphine
pKi 8.22

Ligand (1,597)

eluxadoline
pKi 8.89

nalbuphine
pKi 6.00

naltrexone
pKi 7.99

nalmefene
pKd 9.04

CHEMBL3426794
pEC50 7.00

CHEMBL3426796
pEC50 7.00

CHEMBL3426792
pEC50 7.00

CHEMBL126918
pIC50 7.00

CHEMBL3808415
pKi 7.00

CHEMBL3350127
pKi 7.00

CHEMBL353938
pKi 7.00

CHEMBL258294
pKi 7.00

CHEMBL1161430
pKi 7.00

CHEMBL2048763
pKi 7.00

CHEMBL199294
pKi 7.00

CHEMBL355202
pKi 7.00

CHEMBL1076577
pKi 7.00

CHEMBL409036
pKi 7.00

CHEMBL117183
pKi 7.01

CHEMBL340724
pIC50 7.01

See all 1597 ligands...

Gene RIF (90)

AA Sequence

MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLV      1 - 70
MFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLT     71 - 140
MMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWD    141 - 210
TVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIF    211 - 280
VIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRARE    281 - 350
ATARERVTACTPSDGPGGGAAA                                                    351 - 372
//

Text Mined References (115)

Summary
Details

	PMID	Year	Title

Tclin Delta-type opioid receptor Add to cart View Collections Empty Collection

Property Summary

Knowledge Summary

Patent (2,943)

TINX Plot

Disease (8)

Expression

Differential Expression (7)

Synonym

Gene

PANTHER Protein Class (2)

Ortholog (10)

UniProt Keyword (16)

GO Function (3)

GO Component (10)

GO Process (22)

Compartment GO Term (22)

MGI Phenotype (4)

GWAS Trait (1)

HCA RNA Cell Line (56)

Pathway (21)

PDB (5)

Drug (10)

Ligand (1,597)

Gene RIF (90)

AA Sequence

Text Mined References (115)

Tclin Delta-type opioid receptor

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