Property Summary

NCBI Gene PubMed Count 1,840
PubMed Score 5706.63
PubTator Score 3667.37

Knowledge Summary


No data available


  Disease (10)

Disease Target Count Z-score Confidence
Immune system cancer 38 0.0 1.0
Lymphoid leukemia 69 0.0 1.0
Disease Target Count Z-score Confidence
Multiple Sclerosis 498 3.213 1.6
Crohn's disease 304 0.0 2.0
Disease Target Count Z-score Confidence
Job's syndrome 4 5.855 2.9
Prostate cancer 172 0.0 5.0
Disease Target Count Z-score Confidence
diabetes mellitus 1663 3.6 1.8


  Differential Expression (18)

Disease log2 FC p
psoriasis 1.800 3.4e-07
Rheumatoid Arthritis 1.700 5.6e-03
Multiple myeloma 1.402 1.0e-02
glioblastoma 2.200 6.1e-03
osteosarcoma 2.370 5.1e-07
ependymoma 1.100 4.3e-09
astrocytoma 2.300 1.1e-03
atypical teratoid / rhabdoid tumor 1.300 7.8e-07
Crohn's disease 1.021 5.4e-03
Atopic dermatitis 1.200 1.6e-03
pancreatic ductal adenocarcinoma liver m... -1.832 3.2e-03
intraductal papillary-mucinous neoplasm ... -1.100 2.3e-03
lung cancer -1.900 6.4e-05
adult high grade glioma 1.200 3.2e-04
pilocytic astrocytoma 1.100 3.1e-06
lung adenocarcinoma 1.072 6.8e-04
ovarian cancer 2.500 4.3e-05
pituitary cancer -2.200 8.0e-07

Protein-protein Interaction (3)

Gene RIF (1733)

27048653 These results indicate that ARL3 interacts with STAT3 and regulates the transcriptional activation of STAT3 by influencing its nuclear accumulation of STAT3.
27003258 STAT3 plays an important role in IFN-induced A3G production, and HBsAg may correlated with poor response to IFN treatment
26976343 found STAT3 could bind promoter region of TXNDC17 (-623 bp to -58 bp relative to the transcription start site (TSS)) for regulating its expression
26965998 this study proposes that inflammation-induced Jak-STAT3 signaling leads to colon cancer development through proteasomal degradation of DICER1 by ubiquitin ligase complex of CUL4A(DCAF1), which suggests a novel therapeutic opportunity for colon cancer
26962683 results suggest that IL10-mediated inhibition of autophagy is facilitated by the cross talk between STAT3, AKT, and mTOR; in other words, the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways.
26927669 UT2 is a negative regulator shared across STAT3 and mTORC2 signaling cascades, functioning as a tumor suppressor in hematologic malignancies driven by those pathways.
26898989 The present study finds that the aspirin-FOXD3-OLA1P2-STAT3 axis exhibits exciting anticancer effects and provides new insights into the chemopreventive mechanisms underlying aspirin use
26875895 miR-874 functions as a tumor suppressor by repression of STAT3 in human colorectal cancer cells
26851345 HSP72 blocks fibroblast activation and proliferation in renal fibrosis via targeting the STAT3 pathway and may serve as a novel therapeutic agent for chronic kidney disease regardless of the etiology
26844481 the increased p-stat3 expression may be not only predict poor prognosis, but also be associated with worse tumor differentiation and lymph node metastasis in patients with gastric carcinoma.
26833481 The rs4796793 STAT3 genotype is a novel predictive factor for response to multiple tyrosine kinase inhibitors in metastatic renal cell carcinoma.
26826383 In conclusion, our data suggested that CAFs could activate the anti-apoptotic STAT3 signaling, thereby decrease the Cisplatin-induced apoptosis and promote chemoresistance in ovarian cancer.
26807955 Ceramide induced the binding of STAT3, but not NF-kappaB or c-Jun, to HAMP promoter. Inhibition of STAT3 with a pan-JAK kinase inhibitor and STAT3 siRNA pool also diminished the induction of both HAMP promoter activity and mRNA expression by ceramide.
26806810 Report the interaction between miR-143 and STAT3 prevents cell proliferation/invasion in esophageal squamous cell carcinoma.
26783739 The STAT3-Ser/Hes3 Signaling Axis was first identified as a major regulator of neural stem cells and, subsequently, cancer stem cells
26783521 Our data indicated that Eag1 promotes osteosarcoma proliferation and migration, at least in part, by targeting STAT3-VEGF pathway.
26776907 The endometrium of women with dormant genital tuberculosis is associated with poor receptivity, as evidenced by aberrant LIF-STAT3 signaling.
26775116 colorectal cancer cells secreting IL-6 via STAT3 phosphorylation can enhance the phagocytic capacity and migration of macrophages in the tumor microenvironment.
26774853 This study discovered allosteric communications between STAT3 domains.
26750536 Our data suggested that IL-6 mediates the singnal pathway of JAK-STAT3-VEGF-C promoting the growth, invasion and lymphangiogenesis in gastric cancer
26738536 SEA induces cell cross talk-dependent activation of STAT3 and expression of IL-17 in malignant T cells, suggesting a mechanism whereby SEA-producing bacteria promote activation of an established oncogenic pathway previously implicated in carcinogenesis.
26707908 this study shows that miR-124-3p may negatively regulate the transcription of the STAT3 by interfering with its 3'UTR, and the degradation of STAT3 affects its downstream expression of such as p-STAT3, CCND2 and MMP-2
26707189 Treatment of isolinderalactone increased the protein level of SCOS3, decreased phosphorylation of the STAT3 and suppressed expression of the down-stream genes of the X-linked inhibitor of apoptosis protein
26702067 Identification of a gain-of-function STAT3 mutation (p.Y640F) in lymphocytic variant hypereosinophilic syndrome.
26690371 A novel role of STAT3/miR-21 axis and CDK5/CDK5R1 (p35) in metastasis of head and neck squamous cell carcinoma.
26682870 HSP90 inhibitor ganetespib inhibits pancreatic cancer cell proliferation via JAK2/STAT3 pathway.
26678048 Our results suggest that NFkappaB, STAT1 and STAT3 underlie transcriptional changes and chronic inflammation in the aging human kidney
26676754 STAT3 inhibition in spheroids generated from the established cancer cells and primary glioblastoma patient-derived cells altered the rounded morphology and increased drug sensitivity.
26675719 Using Fgfr4 single nucleotide polymorphism knock-in mice and transgenic mouse models for breast and lung cancers, we validate the enhanced STAT3 signalling induced by the FGFR4 Arg388-variant in vivo
26648570 our data suggest that SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress and inhibition of the activation of the JAK2/STAT3 signaling pathway.
26625308 Suggest that combination therapy with inhibitors of Stat3 signaling may be a useful therapeutic approach to increase the efficacy of Src inhibitors in renal cell carcinoma.
26621504 In conclusion, rheumatoid arthritis synovial fibroblasts were activated by CXCL16 to produce RANKL via pathways involving JAK2/STAT3 and p38/MAPK
26597704 Data show that signal transducer and activator of transcription-3 (STAT-3) activation occurs downstream of leukotriene B4 receptor-2 (BLT2) and mediates cisplatin resistance in SK-OV-3 cells.
26582900 Antisense oligonucleotide AZD9150 decreased STAT3 expression in a broad range of preclinical cancer models and showed antitumor activity in lymphoma and lung cancer models.
26565811 N225K and A550V PTPN6 mutations cause loss-of-function leading to JAK3 mediated deregulation of STAT3 pathway and uncover a mechanism that tumor cells can use to control PTPN6 substrate specificity.
26565555 Studies indicate that cadherins mediate cell to cell interactions are potent activators of the signal transducer and activator of transcription 3 (Stat3), thereby offering survival signaling.
26559373 This review provides a full spectrum of STAT3's involvement in breast cancer by consolidating the knowledge about its role in breast cancer development
26556875 Blockade of p-STAT3 in combination with conventional chemotherapeutic drugs improves cancer stem cell eradication in head and neck squamous cell carcinoma.
26554866 STAT3 is a direct target of miR-506. STAT3 mRNA expression was increased in glioma and inversely correlated with miR-506. Its overexpression attenuated the suppressive effects of miR-506 on cell proliferation, colony formation, migration and invasion.
26553978 STAT3 linker domain mutants to have profound effects of inhibiting STAT3 transcriptional activation.
26549725 Our data suggest that miR-21 expression is increased in breast cancer and plays an important role as a tumor gene by targeting STAT3, which may act as a double-response controller in breast cancer.
26549519 these data indicate that IL-6 inhibits starvation-induced autophagy and that p-STAT3 mediates the signal transduction from IL-6 to downstream proteins including Bcl-2 and Beclin1
26549437 pimozide reduced the basal expression of phosphorylation STAT3 at tyrosine 705 and reversed the expression of phosphorylation of STAT3 induced by IL-6 addition, suggesting that pimozide can suppress cellular STAT3 activation
26546411 lack of p21 has catabolic effects by regulation of aggrecan and MMP-13 expression through STAT3 phosphorylation in the cartilage tissue
26546043 data show decreased nuclear accumulation and transcriptional activity of STAT3 in PAK4-silenced pancreatic cancer cells
26542452 The activation of STAT3 by nuclear PKM2 was associated with gefitinib resistance.
26535690 MicroRNA-29a promotes apoptosis of monocytes by targeting STAT3 during sepsis
26528725 These findings support the notion that salinomycin may be potentially efficacious for targeting breast cancer stem-like cells through the inhibition of STAT3 activation.
26525581 PECs exhibited higher proliferation in response to IL-6/sIL-6R co-treatment compared with TECs in HCC via the up-regulation of gp130 /JAK2/STAT3.
26525579 miR-21 in exosomes leads to STAT3 activation, which increases VEGF levels in recipient cells, a process involved in angiogenesis and malignant transformation of human bronchial epithelial cells
26515594 Data indicate the role of tropomyosin-related kinase-B (TrkB) in activation of the interleukin-6/Janus kinase 2/STAT3 transcription factor and PI3 kinase/c-AKT proto-oncogene protein pathway in breast cancer.
26508835 Paeoniflorin induced growth suppression and apoptosis in human glioma cells through the proteasome-dependent degradation of STAT3.
26508788 These results indicated that the coordinated recruitment of STAT3, CREB-1, and GR to the promoter of the gene encoding COX-2 contributes to the feed-forward induction of COX-2 activity and prostaglandin synthesis in the amnion during parturition.
26500281 Our study indicates that apigenin induces apoptosis through inhibition of STAT3 signalling and could serve as a useful compound to prevent or treat HER2-overexpressing breast cancer.
26482950 The human monocytes are predisposed to differentiate towards an macrophage activation program characterized by the CD16(+)CD163(+)MerTK(+)pSTAT3(+) phenotype and functional properties such as enhanced protease-dependent motility, and immunomodulation.
26482503 miR-125b modulates PCT expression by manipulating the amount and transcriptional activity of Stat3.
26474319 SLURP1 participates in pathophysiology of psoriasis by regulating keratinocyte proliferation and differentiation, and by suppressing the growth of S. aureus
26469385 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
26464031 Letter: Interleukin-22 inhibits tazarotene-induced gene 3 expression in keratinocytes via MAPK-ERK1/2 and JAK2/STAT3 signaling.
26453584 in patients with hyper-IgE syndrome, mutations lead to impaired Th17 cell numbers
26430964 potential utility of a signature involving Bcl-2 overexpression, Rac1 activation and STAT3 phosphorylation for stratifying clinical lymphomas based on disease severity and chemoresistance
26424054 miR-125a-5p directly targets IL-6R and STAT3 expression in HEK-293T cells.
26416274 Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection.
26405196 we have presented data supporting that STAT3beta is a tumor suppressor in ESCC, and STAT3beta can effectively suppress the oncogenic effects of STAT3alpha
26398330 the present study demonstrated that Fzd2 contributes to the migration and invasion of OSCC cells, at least partly through regulation of the STAT3 pathway
26397387 by molecular docking analysis and tumor sphere assay we discover that curcumin was able to inhibit JAK2 activity and reduce tumor spheres via inhibiting the JAK2/STAT3 signaling pathway
26389681 MiR-125a suppresses cervical tumor growth, invasion and metastasis by targeting STAT3.
26387089 data suggest that STAT3 contributes to NK cell recognition by modulating NKG2D ligands in K562/AO2 cells, which may a mechanism by which cells survive and cause relapse of leukemia.
26386651 increased expression in placental endothelial cells associated with pre-eclampsia
26384345 Data show that crizotinib can induce cytoprotective autophagy by suppression of STAT3 transcription factor in lung cancer cells.
26378521 GCN5 Potentiates Glioma Proliferation and Invasion via STAT3 and AKT Signaling Pathways
26370982 SOX2 Promotes the Epithelial to Mesenchymal Transition of Esophageal Squamous Cells by Modulating Slug Expression through the Activation of STAT3/HIF-alpha Signaling
26367487 The level of miR-21 expression positively related to the expression of PDCD4 protein and negatively related to the expression of p-STAT3 protein in salivary adenoid cystic carcinoma specimens.
26363058 IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1.
26360251 Increased STAT3 activation during immune responses.
26359459 PAFR stimulated EMT by activating STAT3 via upregulation of G-protein-dependent SRC or JAK2 kinase activity. STAT3 transcriptionally elevated PAFR expression. A forward feedback loop between PAFR and STAT3 drives the malignant progression of NSCLC.
26353894 Placental endothelial cell-derived PDGF-BB recruits human placental multipotent mesenchymal stromal cells involved in vascular development via PDGFR-beta/STAT3 activation
26353115 onstitutive STAT3 phosphorylation in circulating CD4+ T cells is common in recent-onset untreated RA and associates with good treatment response in patients characterized by high disease activity and the presence of systemic inflammation
26342546 HES5 knockdown resulted in the reduction of p-STAT3
26340407 These findings underscore the importance of understanding the complex interactions between PR and other regulatory factors, such as Stat3, that contribute to determine the context-dependent transcriptional actions of PR.
26339633 The results of the present study clearly demonstrate that the STAT3 pathway triggered by anti-inflammatory IL-27 plays a role in protecting cardiomyocytes against GSC-mediated damage.
26339061 high levels of STAT3 correlate with the refractory state at the single-cell level under conditions of both spontaneous and induced lytic activation; importantly, STAT3 also regulates lytic susceptibility.
26334131 Applying chromatin immunoprecipitation (ChIP) technique and luciferase assay, we further approved that FoxM1 can transcriptionally active signal transducer and activator of transcription 3 (STAT3), ensuring normal HESC differentiation.
26327693 Data indicate that box protein 1, high mobility group (HMGB1) could regulate the expression of STAT3 transcription factor by modulation of its DNA methylation in CD4(+) T cells.
26323925 The positive expression rate of STAT3 was higher in breast cancer tissue compared to normal breast tissue, which was correlated with clinical stage, tumor differentiation, and lymph metastasis.
26321145 IL-25 upregulated PD-L1 surface expression through the signaling pathways of JNK and STAT3, with STAT3 found to constitutively occupy the proximal region of the PD-L1 promoter.
26319552 Silencing Beclin1 in HTLV-1-transformed T cells resulted in diminished activities of NF-kappaB and Stat3 as well as impaired growth.
26314966 Data suggest the therapeutic potential of microRNA miR-23a/interleulin-8 (IL-8)/Stat3 protein (Stat3) signaling axis in nasopharyngeal carcinoma (NPC). radiosensitization.
26314961 STAT3 and miR-21 are cooperative regulators of stemness, migration and tumor initiation in lung-derived brain metastasis
26293184 the STAT3 mutations found in the patient cohort were concluded to be deleterious for normal STAT3 function.
26283727 These data uncover a synthetic lethal interaction involving glutathione production and mitochondrial reactive oxygen species regulation in Ras-transformed cells that is governed by mitochondrial STAT3 and might be exploited therapeutically.
26279438 IL-17 induced STAT3 activation as a necessary step in endothelial cell activation and neutrophil recruitment.
26264211 suggest that STAT3 genotype may identify high-risk women likely to respond more favorably to novel therapeutic combinations that include STAT3 inhibitors
26261078 ATR is down-regulated by STAT3-regulated microRNA-383 in A431 cells.
26260587 Increased IL10, not IL4 or IL13, in senescent eyes activates STAT3 signalling that induces the alternative activation of macrophages and vascular proliferation.
26260288 by controlling a fundamental step in CD1d-mediated lipid antigen presentation, STAT3 signalling promotes innate immune responses driven by CD1d
26255980 Reduced STAT3-dependent gene transcription underlies low Th-17 responses in GOF-STAT1 CMC
26255562 Targeted inhibition of STAT3 combined with gemcitabine enhances in vivo drug delivery and therapeutic response in pancreatic ductal adenocarcinomas.
26255115 Downregulation of STAT3 phosphorylation enhances tumoricidal effect of IL-15-activated dendritic cell against doxorubicin-resistant lymphoma and leukemia via TNF-alpha.
26253946 RNAi-mediated silencing of Anxa2 inhibits breast cancer cell proliferation by downregulating cyclin D1 in STAT3-dependent pathway.
26245900 BCL-XL up-regulation by STAT3 contributes to mutant KRAS-mediated apoptosis resistance. Such resistance can be overcome by potent BIM induction and concurrent BCL-XL antagonism
26244872 Data provide the first evidence that de-regulated Jak3/STAT3/STAT5 signalling in CTCL cells represses the expression of the gene encoding miR-22, a novel tumor suppressor miRNA.
26238950 Study showed low expression level of miR-519d associated with TNM staging and metastasis of breast cancer, and suggested it as a tumor suppressor with role in breast cancer cell proliferation and invasion by downregulating STAT3.
26238781 Activation of c-Src/STAT3 signaling by Ceacam1L is a crucial factor in glioblastoma-initiating cell maintenance and tumorigenesis. Monomers of the cytoplasmic domain of Ceacam1L bound to c-Src and STAT3 and induced their phosphorylation.
26238612 The present study therefore demonstrated that 2-alkyl substituted quinazolines target the JAK2/STAT3 pathway for their antitumor activity
26233579 Positive expression of pSTAT3 is associated with poor prognosis in gastric cancer patients.[review; meta-analysis]
26215634 Increased expression of SgK223 occurs in PDAC, and overexpression of SgK223 in pancreatic ductal epithelial cells promotes acquisition of a migratory and invasive phenotype through enhanced JAK1/Stat3 signaling
26204395 Both studied polymorphisms in the STAT3 gene seem to play a significant role in susceptibility to Hashimoto's thyroiditis (HT) and Graves' disease.
26198641 STAT3 and CDKN2A deletions co-occurred with high frequency in PCa metastases.
26191214 Glycyrrhizic acid inhibits leukemia cell growth/migration by blocking AKT/mTOR/STAT3 signaling.
26191195 miR-204 targets JAK2 and suppressed JAK2 and p-JAK2 expression in breast cancer, which further inhibit the activation of STAT3, BCl-2 and survivin.
26188635 Mutations leading to constitutive active gp130/JAK1/STAT3 pathway.
26186918 Study demonstrate that STAT3 rs744166 G allele is associated with increased risk of gastric cancer in a Western population.
26184999 These results suggest that STAT3 inhibition, by down-regulating the expression of HSF1/HSP70, reduces Mcl-1 and leads to both apoptosis and autophagy induction in PEL cells.
26163643 Single Nucleotide Polymorphism rs1053004 in STAT3 gene is associated with Susceptibility to Hepatocellular Carcinoma with Chronic Hepatitis B.
26158169 STAT3 activation may induce invasion and metastasis through the mediation of epithelial-to-mesenchymal transition in hepatocellular carcinoma cells.
26156799 Our results suggested that STAT3 phosphorylation is involved in PLCe-mediated inflammatory cytokine release
26153131 JAK2/STAT3 inhibitor AG490 inhibited the leptin-induced migration, invasion and MMP-2 expression in endometriotic cells. Leptin does this via the up-regulation of MMP-2 through an ObR-dependent JAK2/STAT3 signaling pathway.
26151358 B7H3 promotes cell migration and invasion through the Jak2/Stat3/MMP9 signaling pathway in colorectal cancer
26150336 cardamonin is a novel inhibitor of STAT3 and has the potential to be developed as a new anticancer agent targeting Glioblastoma stem cells ... targeting STAT3 signal pathway is an important strategy for the treatment of human glioblastoma multiforme
26146825 Data show that both signal transducer and activation of transcription factors STAT5 and STAT3 were activated in significant percentages of cells in atypical ductal hyperplasia (ADH).
26144873 Mice treated with STAT3 inhibitor galiellalactone had smaller primary prostate tumors and decreased lymph node metastases.
26141261 gene deficiency is associated with vasculopathy
26130650 Expression analysis revealed upregulation of IL6 and CD126 and GP130 in ALDH(hi) endometrial cancer ... targeted inhibition of the IL6 receptor and its downstream effectors JAK1 and STAT3 reduced tumor cell growth.
26125778 RPTS can significantly promote apoptosis in SW480 colorectal cancer cells. The mechanism may be that it suppresses the secretion of IL-6 and inhibits the IL-6/JAK-STAT3 protein signaling pathway.
26124007 our results suggest that the BMP-2 induced STAT3-mediated induction of colon cancer cell metastasis requires an EMT and/or changes in cancer stem cell markers
26116514 The gp120-triggered modulation of miR expression via STAT3 activation.
26116514 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
26115905 STAT3 signaling is a key element that regulates keratinocyte differentiation.
26109806 Paeoniflorin inhibits cell viability and induces apoptosis through the up-regulation of miR-124 and suppression of PI3K/Akt and STAT3 signaling in gastric carcinoma cells.
26101800 In arsenite-transformed HaCaT (HaCaT-30T) cells, down-regulation of STAT3 by siRNA blocked the process of epithelial-mesenchymal transition and decreased their neoplastic properties that were antagonized by over-expression of miR-21.
26100622 STAT3 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin and SRF.
26091577 Increased ADMA may lead to manifestation of pulmonary hypertension phenotype in human endothelial and smooth muscle cells via the STAT3/HIF-1alpha cascade.
26080800 Results suggest that STAT3 activity is correlated with CSF IL-10 level, which is a useful marker for STAT3 activity in primary central nervous system diffuse large B-cell lymphoma
26063618 meta-analysis suggests that the STAT3 rs12949918 and rs744166 polymorphisms, but not other three polymorphisms, may be an important protective factor for cancer
26055806 STAT3 phosphorylation is increased following overexpression of miR-155 in CD4+ T cells.
26054691 Lethe, which was upregulated by activated STAT3, may promoting the replication of HCV through a negative regulatory mechanism of type I IFN response.
26051842 miR-21 and let-7a function as clinically relevant integral components of STAT3 signaling.
26045780 Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-beta1/Smad3 signaling pathway in vitro.
26041409 activation of Src/STAT3/HO-1/autophagy signaling pathway might play a general role in protecting certain subtypes of breast cancer cells from doxorubicin-induced cytotoxicity
26039995 sorafenib and SC-1 ameliorate liver fibrosis through STAT3 inhibition in HSC and STAT3 may potentially serve as a promising fibrotic biomarker and target in liver fibrosis
26026268 results suggest that SIPAR terminates the activation of STAT3 through a dephosphorylation process that is dependent upon interaction with TC45 in the nucleus
26024373 Phospho-STAT3 might be a prognostic factor of patients with digestive system cancers.
26002461 Protein and mRNA levels of PCBP2 were down-regulated under insulin-resistant conditions. Over-expression of PCBP2 inhibits HIF1alpha and STAT3 pathway.
25992623 The activation of Fas signaling promoted cell migration and resulted in STAT3-dependent Fascin upregulation in AGS gastric cancer cells.
25984943 With the exception of one line of activated B cell Diffuse Large B Cell Lymphoma cells, the four variants were found in roughly the same ratios despite differences in total levels of STAT3 transcripts.
25982282 PTPRT promoter methylation is significantly associated with sensitivity to STAT3 inhibition in HNSCC cells, suggesting that PTPRT promoter methylation may serve as a predictive biomarker for responsiveness to STAT3 inhibitors in clinical development
25977172 STAT3 inactivation reverses the glycolytic shift by down-regulating key enzymes and that it induces up-regulation of latexin as a tumor-suppressor molecule, which partially results in cancer cell apoptosis and tumor growth suppression.
25973748 STAT3 mediates GRP78-promoted breast cancer cell growth and migration.
25973100 Our study found that STAT3 rs4796793 polymorphism plays an important role in influence the development and overall survival of breast cancer patients.
25968456 these findings indicate that constitutive IL6/STAT3 pathway activation is important in driving tumor growth and inflammatory cross-talk with myeloid cells within the Group A EPN microenvironment.
25968054 These results show that temporarily increasing STAT3 activity is sufficient to reprogram human pluripotent stem cells to naive-like pluripotent cells.
25967142 we demonstrate the accumulation of granulocytic MDSCs with prostate cancer progression and the feasibility of using TLR9-targeted STAT3siRNA delivery strategy to alleviate MDSC-mediated immunosuppression
25966666 Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6/gp130/STAT3 Pathway.
25962528 mutations result in hyper-IgE syndrome, which is treated by hematopoietic stem cell transplantation
25961936 STAT3 acts as a mediator that synergizes TGF-beta and Ras signals
25954856 we demonstrated that recombinant human OSM (rhOSM) promoted tumor angiogenesis in EC cell lines by activating STAT3 (signal transducer and activator of transcription 3) and enhanced both cell migration and cell inva
25941256 STAT3 signaling downstream of IL-23R and IL-21R has a role in controlling human mucosal-associated invariant T cells and NKT cell numbers
25931145 weak RELA-activation signals (CD40L, LPS) depended on IFN-gamma induced STAT1/IRF1/IRF8 co-signalling, which was completely blocked by JAK inhibitors as reported before
25928665 miR-124 functions as a tumor suppressor in esophageal cancer through, at least partially, targeting STAT3 signaling pathway.
25921106 Polymorphism in STAT3 gene is not associated with cervical cancer.
25907691 ferristatin II synergized with BMP6 and IL-6 to enhance hepcidin expression in vitro, However, this synergy was not due to activation of either Smad or Stat3 signaling
25902005 USP22 attenuated the invasion capacity of colon cancer cells by inhibiting the STAT3/MMP9 signaling pathway.
25899746 findings disclose a discrepancy in cellular response to STAT3 inhibition between non-HBV-related and HBV-related HCC cells and underscore the complexity of antiproliferative effect of STAT3 inactivation in HBV-related HCC cells
25896424 Our results suggest the significance of STAT3 activation in the maintenance and survival of ovarian cancer cells
25896132 STAT3 and STAT5A were bound to the xCT promoter.
25893308 Identification of a novel tumor-promoting function for IGFBP2 of activating EGFR/STAT3 signaling and facilitating EGFR accumulation in the nucleus, thereby deregulating EGFR signaling by two distinct mechanisms.
25892518 Endogenous PML suppresses interleukin (IL)-6-induced gene expression as well as phosphorylation and transcriptional activation of STAT3 in hepatoma cells.
25881542 Stat3 functions at the level of the microenvironment of brain metastases. Stat3 controlled constitutive and inducible VEGFR2 expression in tumor-associated brain endothelial cells.
25880788 Data suggest that STAT Transcription Factors STAT1 and STAT3 defects have different effects on trained immunity.
25880754 CD4 T cells from patients with RA have abnormal functional networks in STAT3 signaling and Wnt signaling.
25869100 Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin signaling due to the dissociation of beta-catenin/TCF-1 complex and the process was orchestrated by STAT-3.
25868978 Findings suggest a crucial roles for resistin, IL-6 and STAT3 in breast cancer racial disparity.
25857630 Study demonstrates that HPV+ and HPV-head and neck squamous cell carcinoma(HNSCC) are differentiated by the activity of key transcription factors (TFs) including STAT3 and NF-kappaB. Approximately 25% of primary HNSCC, almost exclusively HPV-, have these TFs and their targets coordinately upregulated.
25854938 Persistent activation of STAT3 by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer.
25854163 MRTF-A and STAT3 synergistically recruited DNMT1 to hypermethylate the promoter of BRMS1 and affect the expression of BRMS1.MRTF-A and STAT3 promote breast cancer cell migration via hypermethylating BRSM1.
25849952 Myricitrin treatment protects endothelial cells from ox-LDL-induced endothelial cell apoptosis, which results in reduced atherosclerotic plaque formation, via STAT3 signaling.
25849286 Delta tocotrienol treatment inhibits ETK phosphorylation level and induces SHP-1 expression, which correlates with downregulation of STAT3 activation.
25847223 These findings suggest that IL-6 blocking reduces the inflammatory mechanisms through the correction of STAT1 and STAT3 activation status.
25847123 SIRT1 and STAT3 expression protects retinal pigmented epithelium cells against oxidative stress.
25846563 active forms of STAT3 (pSTAT3) and GSK-3beta (pGSK-3beta) were found in 68 (25%) and 124 (46%) of 267 gastric cancer cases, respectively, showing a positive correlation (p < 0.001)
25845340 Simultaneous silencing of beta-catenin and STAT3 synergistically induces apoptosis and inhibits cell proliferation in HepG2 liver cancer cells.
25840984 we defined a role for activated STAT3 and G9a histone methyltransferase in epigenetic silencing of miR-200c, which promotes the formation of breast CSCs defined by elevated cell surface levels of the leptin receptor
25840690 there is a regulatory pathway consisting of miR-30, SOCS3, and Jak/STAT3 in GSCs, and targeting this pathway may be a promising strategy to treat glioma.
25837197 Jak1/Stat3 activation may mediate the activation of NF-kappaB and the expression of IL-8 in H. pylori-infected AGS cells.
25833829 PAR3-mutant proteins exhibit a relative reduction in the ability to mediate formation of tight junctions and actin-based protrusions and activate STAT3 at cell confluence.
25833823 Aberrant STAT3 and HIF1a activity drives tumor progression in malignant peripheral nerve sheath tumors.
25832656 our findings showed how FoxM1 activates expression of PDGF-A and STAT3 in a pathway required to maintain the self-renewal and tumorigenicity of glioma stem-like cells.
25825152 The role of STAT3 in tumorigenesis
25824741 Constitutive activation of STAT3 is associated with myeloproliferative neoplasm.
25824337 Data show that calcitriol inhibited interleukin 6 (IL6) in association with an attenuation of STAT3 transcription factor activation.
25823926 macrophages promoted BaP-induced malignant transformation of human bronchial epithelial cells, which was mediated by nuclear factor (NF)-kappaB and STAT3 pathways to induce cell proliferation, colony formation in chip culture, and tumorigenicity in nude mice.
25822437 Report diffuse expression of STAT3 in gastric adenocarcinomas.
25811798 In this study, nifuroxazide not only decreased expression of Stat3 phosphorylation at tyrsione residue 705 but also downregulated MMP-2 and MMP-9 expression in 4T1 cells.
25789467 Genetic variants of STAT3 might contribute to anti-tuberculosis drug-induced hepatitis susceptibility in Chinese Han population.
25787299 Its signaling pathway plays a role in tumor angiogenesis.
25774503 Pituitary adenoma GH hypersecretion is the result of STAT3-dependent GH induction, which in turn promotes STAT3 expression.
25773877 Increased expression of STAT3 was associated with metastases in Colon Carcinoma.
25771405 functions as a co-activator for nuclear activity of RelB/p52 in positive regulation of pro-labor genes in the placenta
25767098 STAT3-driven transcription is dependent on dimethylation of K49 by EZH2
25760445 Efficacy of the FLLL32 pharmacological inhibitor in delaying OS growth suggests that targeting JAK2/STAT3 may be a potential therapeutic strategy for patients with OS.
25754378 This study collectively showed that Polygonum flavonoids could induce liver carcinoma cell apoptosis both in vitro and in vivo.
25752465 Decreased Stat3 expression and activation may play an important role in the pathogenesis of preeclampsia.
25750173 this study proposes the existence of an aberrant IL-6/STAT3/Fra-1 signaling axis leading to colorectal cancer aggressiveness through epithelial-mesenchymal transition induction
25750101 aberrant activation of STAT3 signaling plays an important role in the pathogenesis of endometriosis
25748242 We conclude that OSM-mediated signaling contributes to aggressive nature associated with mesenchymal features via STAT3 signaling in glioma cells.
25747354 GP130/STAT3 pathway is activated in NAFLD and can worsen insulin resistance while protecting against other lipotoxic mechanisms of disease pathogenesis.
25740948 Noncanonical STAT3 activation regulates excess TGF-beta1 and collagen I expression in muscle of stricturing Crohn's disease.
25735252 Authors identified nuclear pSTAT3 expression in 59.76 % of tumors. pSTAT3 expression was correlated with differentiation degree of tumors, lymph node metastasis status, clinical stage of tumors and the prognosis of NSCLC patients after resection.
25734337 STAT3 controls NF-kappaB-induced IL-8 expression by sequestering NF-kappaB within the cytoplasm, thereby inhibiting IL-8-mediated myeloid tumour infiltration and tumour vascularization and hence tumour progression.
25726111 Targeted bovine-derived proteins were evaluated for their effects on signal transducer and activator of transcription-3 (STAT3) phosphorylation in human skeletal muscle cells.
25717101 STAT3 functions via cellular PCBP2 to regulate B-cell lytic susceptibility by restraining Epstein-Barr Virus lytic activation.
25713425 Decreased STAT3 in human idiopathic fetal growth restriction contributes to trophoblast dysfunction.
25706309 revealed a tri-lateral relationship among HPV infection, Stat3 activity and IL17 level, whose collaborative act may orchestrate a proinflammatory microenvironment in the colorectum that may promote carcinogenesis and possibly facilitate progression of CRC
25704763 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
25697898 the expression of IL-6 was significantly higher in MBT-SCs. Additionally, the expression of STAT3 in MCF-7 cells increased slightly when they were co-cultured with malign breast tissue-derived stromal cells
25695729 SOCS3 negatively regulates proliferation and angiogenesis of NCI-H446 cells and that HIF-1alpha is required in this process. The results also suggested a suppressive role of SOCS3 in Akt signaling, but not STAT3 signaling to block HIF-1alpha expression
25684945 The overexpression of B7-H3 induces resistance to apoptosis in colorectal cancer cell lines by upregulating the Jak2-STAT3 signaling pathway
25684140 To drive STAT3 activation and EMT through STAT3-mediated TWIST1 induction.
25681443 PDLIM2 repression is essential for KSHV-induced persistent activation of nuclear factor kappaB (NF-kappaB) and signal transducer and activator of transcription 3 (STAT3) and subsequent tumorigenesis and tumor maintenance
25673868 Our data demonstrate that the JAK/STAT3 pathway is a common mediator of astrocyte reactivity that is highly conserved between disease states
25671570 fad104 suppressed the invasion and metastasis of melanoma cells by inhibiting activation of the STAT3 signaling pathway
25666256 High STAT3 expression is associated with the pathogenesis of myeloproliferative neoplasm.
25663681 pSTAT3 Y705 is increased in T4 cells among human recipients of allogeneic HCT before the onset of Grade II-IV acute GVHD. STAT3 signaling and resultant Th17 tissue accumulation are associated with acute GVHD onset, severity, and treatment outcome.
25655308 Taken together, these results illustrate that, as a potent inhibitor of HIF-1alpha and Stat3 signaling, LB-1 exhibits antitumor effect and could be potentially used to treat pancreatic cancer.
25653024 STAT3 overexpression reduced E-cadherin and beta-cadherin. It enhanced N-cadherin and vimentin expression in SMMC7721 cells. STAT3 may bind the Twist promoter, mediate its transcriptional activity, and then promote the EMT in SMMC7721 cells.
25613134 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
25612622 PTPRK underexpression leads to STAT3 activation and contributes to nasal NK/T-cell lymphoma pathogenesis
25611565 STAT3 signaling has a role in quercetin-induced endoplasmic reticulum stress that enhances cDDP cytotoxicity in ovarian cancer
25609248 STAT3 inhibitor OPB-51602 demonstrates promising antitumor activity, particularly in NSCLC.
25609240 Phosphorylated placental STAT3 is increased in women with polycystic ovary syndrome.
25605256 Suggest that ERp57-STAT3 regulation functions in radioresistance of laryngeal cancer.
25604748 MicroRNA-19a functions as an oncogenic microRNA in non-small cell lung cancer by targeting the suppressor of cytokine signaling 1 and mediating STAT3 activation
25593461 Butein ameliorated colitis in IL-10(-/-) mice by regulating IL-6/STAT3 and MMP-9 activation.
25586740 MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-beta/Smad2/STAT3/STAT5 pathway
25586472 STAT3 and STAT5B mutations are associated with increased phosphorylated protein and a growth advantage to transduced cell lines or normal NK cells
25582338 increased activity in the IL-15-derived dendritic cells has a key role in their high effector function
25572805 Our data suggested that tumor-associated macrophages might induce drug resistance through IL-10/STAT3/bcl-2 signaling pathway
25571964 the present study revealed the aberrant expression of STAT3 and miR21 in hepatocellular carcinoma side population cells.
25568075 Suggest that under conditions of sustained increases in hexosamine biosynthetic pathway activity there is an increase in basal STAT3(Y705) phosphorylation that cannot be further increased by leptin.
25556369 Stat3 was found to directly interact with 14-3-3zeta and its disruption relieved the inhibition induced by 14-3-3zeta in tumor inflammation; study provides evidence that 14-3-3zeta may regulate tumor inflammation and immune response through Stat3 signaling in oral squamous cell carcinoma.
25550842 STAT3 and cyclinD1 correlate with more aggressive tumor behavior in esophageal squamous cell carcinoma. When STAT3 and cyclinD1 are considered together, they serve as effective prognostic markers in patients with surgically resected ESCC.
25550533 Curcumin and epigallocatechin gallate specifically inhibit STAT3 phosphorylation in cancer stem cells.
25544568 Notch1 promotes epithelial-mesenchymal transition and the cancer stem cell phenotype through induction of STAT3.
25543043 A novel mutation in the STAT3 in Hyper IgE syndrome is reported
25539644 Results demonstrate existence of a functional loop involving Let-7a, STAT3 and miR-21 which were found potentially regulated by viral oncoprotein E6.
25537973 Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak2 and Stat3 pathway
25531908 our findings suggest that miR-124 functions as a tumor suppressor by targeting STAT3, and that miR-124 may potentially serve as a useful biomarker for the prognosis of non-small cell lung cancer patients.
25522626 Data indicate that ethanol extract from Sedum sarmentosum (ESB) inhibits HepG2 cell proliferation and induces apoptosis by inhibiting signal transducer and activator of transcription 3 (STAT-3) signaling.
25514838 STAT3/miR-21 axis could be a candidate therapeutic target for OSCC chemoresistance.
25510212 this study identified a marked activation of Human beta-defensin-2 expression in human alveolar epithelial type II cells by IL-22 through STAT3-dependent mechanisms.
25504436 signalings can reciprocally and positively regulate each other, leading to enhanced non-small cell lung cancer (NSCLC) cell proliferation and survival.
25491772 Increased expression of the Th17-IL-6R/pSTAT3/BATF/RorgammaT-axis in the tumoural region of adenocarcinoma as compared to squamous cell carcinoma of the lung
25487443 These results indicated that STAT3 and STAT5b polymorphisms might be a candidate pharmacogenomic factor to assess susceptibility and prognosis in breast cancer patients.
25485912 Endocytic AMR controls TPO expression through Janus kinase 2 (JAK2) and the acute phase response signal transducer and activator of transcription 3 (STAT3) in vivo and in vitro
25481644 Our findings demonstrate that leptin-induced STAT3 is partially cross activated through SK1-mediated IL6 secretion and gp130 activation. Positive correlations in human tissues suggest the potential significance of this pathway in ER-negative breast cancer
25477471 Mechanical stretch upregulated fibronectin and TGF-beta1 expression and activated STAT3 in proximal renal tubular epithelial cells.
25477266 The results provide evidence that the regulation of IL-6, IL-10, c-Jun, and STAT3 gene expression in Chronic lymphocytic leukemia B cells is clearly different from normal B lymphocytes.
25476455 These findings suggest that INPP5F is a potential tumor suppressor in gliomas via inhibition of STAT3 pathway, and that deregulation of INPP5F may lead to contribution to gliomagenesis.
25471787 High SMYD3 and pSTAT3 expressions may indicate poor prognosis of patients with gastric cancer
25460081 reveal a novel role for E2 in regulating the activities of NF-kappaB and STAT3 that may have implications in carcinogenic progression of HPV16-infected cells under conditions of stromal inflammation
25458989 SOCS3 and STAT3 are the major controllers of the outcome of infection with Mycobacterium tuberculosis. (Review)
25450293 High serum leptin may reduce endometrial receptivity by activating the STAT3 signal pathway and down-regulating gamma-ENaC expression in the endometrium.
25444909 High STAT3 expression was associated with pancreatic cancer.
25439778 Cten expression mediates invasion of human lung cancer cells and is upregulated by epidermal growth factor via STAT3.
25428919 CD147 has a role in promoting Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells
25419841 Data show that cultured keratinocytes treated with STAT3 transcription factor inhibitor (Stattic) survived longer, produced higher titers of virus, and showed reduced activation of type I interferon responses and inflammatory cytokines release.
25417721 Studied the possible relationship between STATIP1, STAT3 and CML resistance.
25412315 BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells.
25411359 High STAT3 induces anoikis resistance, promotes cell invasion and metastatic potential in pancreatic cancer.
25407307 Stat3, phosphorylated Stat3, and MMP2 were overexpressed in esophageal squamous cell carcinoma (ESCC) and associated with invasion of ESCC. Stat3 up-regulated expression of MMP2 in ESCC through directly binding to the MMP2 promoter.
25405790 these findings revealed that macrophages that have infiltrated tumors may induce epithelial-mesenchymal transition of HCC cells via the IL-8 activated JAK2/STAT3/Snail pathway.
25405516 our results show that 20(S)Rg3 inhibits the Warburg effect by targeting STAT3/HK2 pathway in ovarian cancer cells, highlighting the potentiality of 20(S)Rg3 to be used as a therapeutic agent for ovarian cancer
25405202 JAk2/STAT3 plays a key role in CCR7 regulatingSquamous cell carcinoma of the head and neck metastasis.
25365510 Activation of miR-21 by STAT3 induces proliferation and suppresses apoptosis in nasopharyngeal carcinoma by targeting PTEN gene
25359994 These results suggest that there is a broad range of autoimmunity caused by germline STAT3 gain-of-function mutations, and that hematologic autoimmunity is a major component of this newly described disorder.
25359779 STAT3 activation is related to the up-regulation of miR-17-92 clusters in retinoblastoma cells via positive feedback loop between them
25352693 These results suggest that calpain plays an important role in E. histolytica-induced degradation of NF-kappaB and STATs in colonic epithelial cells, which ultimately accelerates cell death.
25349174 results broaden the spectrum of phenotypes caused by activating STAT3 mutations, highlight the role of STAT3 in the development and differentiation of multiple immune cell lineages
25348333 The STAT3/beta-catenin interaction is complex but may reduce the proliferative activity of beta-catenin possibly by taking beta-catenin protein beyond the optimal level.
25347472 Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.
25342631 In addition to its established role as a transcription factor in cancer, STAT3 regulates mitochondrion functions, as well as gene expression through epigenetic mechanisms. [review]
25337261 pSTAT3-VEGF signaling pathway, which is correlated with peritumoral edema extent, might be a regulatory mechanism in the course of peritumoral edema formation during glioblastoma tumorigenesis and progression.
25337233 Data suggest that RKIP inhibits gastric cancer metastasis via the downregulation of its downstream target genes STAT3 and cyclin D1.
25333344 CYP2E1 expression regulation occurred via a transcriptional mechanism involving STAT3.
25327561 Suggest that feedback activation of STAT3 via up-regulation of MUC1/4 expression constitutes a key node mediating trastuzumab resistance.
25323535 LIF has a role in negatively regulating tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers
25321483 On the corresponding BMF gene promoter, loss of HDAC8 was associated with signal transducer and activator of transcription 3 (STAT3)/specificity protein 3 (Sp3) transcription factor exchange and recruitment of p300.
25318604 CCL2 greatly enhanced IL-6-induced EMT events mainly by upregulating the expression of Twist. Genetic or pharmacological inhibition of STAT3 disrupted STAT3-centered loop and markedly suppressed Twist expression as well as IL-6/CCL2-mediated EMT induction
25313011 RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma.
25310198 Targeting the CXCL12-CXCR4/JAK2/STAT3 signaling pathway may be a potential therapeutic strategy for the treatment of breast cancer.
25299776 Mitochondrial pSTAT3Ser(727) is part of the antioxidant defense pathway of chronic lymphoid leukemia B cells that regulates their viability.
25286337 associations between STAT3 rs744166 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease
25285632 results demonstrated that feedback activation of the IL6-STAT3 loop lead to acquired resistance to PI3K inhibitors by promoting EMT and CSC-like features
25281507 STAT3 mutations are associated with large granular lymphocytic leukemia progression.
25280942 IL-32theta;, through its interaction with PKCdelta, downregulates CCL5 expression by mediating the phosphorylation of STAT3 on Ser727 to render it transcriptionally inactive.
25275020 STAT3 activation in T-cells with neoplastic morphology is associated with the presence of eosinophils in situ and that malignant T-cell lines produce activators of eosinophils through both STAT3-dependent and -independent pathways.
25269647 ZER suppressed EGF-induced CD44 expression through inhibition of the STAT3 pathway. Therefore, we suggested that ZER may act as a promising therapeutic drug for the treatment of breast cancer.
25261367 NDRG2/gp130/STAT3 pathway can mediate the antimetastatic effects of Dp44mT in hepatocellular carcinoma.
25261365 Data suggests that targeting both tumor initiating and differentiated cell populations by STAT3 inhibition is predicted to have greater efficacy for prostate cancer treatment.
25252914 Autocrine activation of STAT3 in MCF-7 cells ectopically expressing OSM-induced cellular scattering.
25248379 STAT3 mediates regorafenib-induced apoptosis in hepatocellular carcinoma.
25242236 High Stat3 protein expression is associated with lung cancer.
25242136 To be associated with signal transducer and activator of transcription 3 pathway inhibition.
25239565 A novel IL-6/Stat3-miR-17-92 cluster-PTEN signaling axis is crucial for cholangiocarcinogenesis and tumor progression.
25234193 Results suggest that piperine may exert at least part of its anti-cancer effect by controlling interleukin-6 (IL-6) expression through the suppression of p38 MAPK and STAT3 protein.
25231991 IL-6 has a major role in activating breast stromal fibroblasts through STAT3-dependent AUF1 induction
25231320 ER stress induced endogenous expression of CCL5 via elevating U-STAT3 expression; however, ER stress inhibited CCL5 secretion, which in turn, decreased the transmigration of breast cancer MCF-7 cells.
25220423 The data revealed a protective role of autophagy in the radiosensitizing effects of STAT3 inhibition, and inhibition of both autophagy and STAT3 might be a potential therapeutic strategy to increase the radiosensitivity of glioma cells.
25219839 The present study provides compelling experimental evidence that Ang-II/AT1 receptor/STAT3 is an important signaling pathway in the atrial myocardium.
25217633 Unphosphorylated-STAT3 plays an important role in angiotensin II-induced gene expression and in the consequent development of cardiac hypertrophy and dysfunction.
25213863 In addition to IL-6, TNF-alpha increases Stat3 and NFkappaB binding to the fascin promoter to induce its expression.
25213258 By inducing autophagy via the ERK/AKT-mTOR-STAT3-Notch signaling cascade.
25208211 IL-22 activates miR-197 expression through the binding of phosphorylated STAT3 to sequences in the putative promoter of miR-197.
25205818 Data suggest that STAT5A and STAT5B (highly conserved genes; 96% identity in amino acid sequences) are nearly identical in responses to growth hormone; STAT1 and STAT3 exhibit weaker binding to DNA elements in insulin-like growth factor-I gene.
25200966 NTS/IL-8/CXCR1/STAT3 signaling is crucial for the maintenance of stem-like traits in glioblastoma stem cells .
25200186 results suggest that GPR30 is the estrogen receptor that mediates the anorectic effect of estrogen through the STAT3 pathway in the hypothalamus
25194807 The present study concluded that IL-27 reduces lipid accumulation of foam cell by upregulating ABCA1 expression via JAK2/STAT3.
25192910 TRPM7 activates JAK2/STAT3 and/or Notch signaling pathways and leads to increased cell proliferation and migration.
25187566 Both Stat3 and Stat5 mediate trans-activation and epigenetic remodeling of IL10 through their interaction with the histone acetyltransferase p300.
25181692 Incubation of hepatocarcinoma cell lines with tocilizumab or knockdown of signal transducer and activator of transcription 3 reduced the ability of macrophages to promote sphere formation by CD44+ cells.
25175640 Expression of p-STAT3 is upregulated in peripheral CD4+ and CD8+ T cells of hepatocellular carcinoma patients.
25174872 IL-10/Janus kinase/STAT3 signaling dysregulates Bim expression in autoimmune lymphoproliferative syndrome.
25174320 These results illustrate the novel activity of the C5a-C5aR axis that promotes human NPC cell proliferation through PCAFmediated STAT3 acetylation.
25170622 Factors released by CBMSCs protect endothelial cells from the deleterious impact of GSD by activation of the STAT3 survival pathway
25153349 the inhibition of STAT3 signaling by NDRG2 suppresses EMT progression of EMT via the down-regulation of Snail expression
25151145 AngII/Rac1/STAT3 signaling as a mechanism for atrial structural remodeling
25139989 These findings demonstrate a distinct role for STAT3 signaling in basal breast cancers, and underscore the importance of considering subtype-specific molecular pathways that contribute to tissue-specific cancers.
25139404 STAT3 binds to the -201 to -210 region of PRL-3. STAT3 functionally regulates PRL-3. STAT3 core signature was enriched in AML with high PRL-3 expression. The STAT3/PRL-3 regulatory loop contributes to the pathogenesis of AML.
25136113 Gain-of-function and loss-of-function studies with cultured mouse and human basal cells suggest that IL-6/Stat3 signaling promotes ciliogenesis at multiple levels.
25134459 STAT3 is a critical signaling node in BCR-ABL1 tyrosine kinase-independent leukemia resistance that is reversed by a discovered BP-5-087.
25132422 These data suggest that the STAT3 locus is associated with both inflammatory bowel disease and colon cancer
25130172 ATF4 may promote multidrug resistance in esophageal squamous cell carcinoma cells through the up-regulation of STAT3 expression
25126546 This study directly depicts STAT3-mediated miRNA profiles in CRC cells, which provides a possible way to discover biomarkers for Colorectal cancer therapy.
25124686 Low PIAS3 expression in malignant mesothelioma is associated with increased STAT3 activation and poor patient survival.
25110240 STAT3 and MMP-2 have a role in the diagnosis of colon adenocarcinoma and the detection of the degree of differentiation
25107644 STAT3 signaling in human cancer cells is blocked by N6-substituted adenosine analogues, a novel class of JAK2 inhibitors
25101566 STAT3 is negatively regulated by lupeol, inhibiting growth and inducing apoptosis, in hepatocellular carcinoma cells.
25098409 TLR9 ligands induce S100A8 in macrophages via a STAT3-dependent pathway which requires IL-10 and PGE2.
25096061 in human HCC tissues, SPTBN1 expression correlated negatively with expression levels of STAT3, ATF3, and CREB2; SMAD3 expression correlated negatively with STAT3 expression
25092916 Data support a model in which EWS/FLI1 deficiency results in the secretion of soluble factors, such as IL6, which activate STAT3 in bystander cells that maintain EWS/FLI1 expression.
25083589 Suggest tectochrysin leads to apoptotic cell death in NSCLC cells through activation of DR3 and Fas expression via inhibition of STAT3 phosphorylation.
25070240 ISL-1 is tightly linked to non-Hodgkin lymphoma proliferation and development by promoting c-Myc transcription, and its aberrant expression was regulated by p-STAT3/p-c-Jun/ISL-1 complex activation.
25070049 MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the Epithelial-mesenchymal transition of breast cancer stem cells by down regulating the STAT3 pathway
25065853 Many drug-treated oncogene-addicted cancer cells engage a positive feedback loop leading to Stat3 activation.
25063873 RelB-p52 dimers were found to directly bind to the IDO promoter, leading to IDO expression in MDSCs
25063444 IL-22 conferred resistance to 5-FU and OXA by inducing IL-8 autocrine expression through STAT3 activation.
25063062 Investigated the effects of mTOR-STAT3 pathway on the invasion and migration of hepatoma cells.
25041018 Pretreatment with a STAT3 inhibitor also augmented SRP induced growth inhibition and cell apoptosis.
25038750 The critical role of STAT3 in autoimmune disease.
25038455 data thus provide important and novel insights into the roles of MRTF-A and STAT3 in regulating MDA-MB-231 cell migration.
25031744 Our data indicate that expression of both CD44s and pSTAT3 in clear cell renal cell carcinoma is associated with advanced tumor stage and patient survival
25031733 the high proportion of pSer727-STAT3 positive neoplastic cells in glioblastoma is an independent unfavorable prognostic factor
25014397 Common variations of STAT3 could significantly affect the risk of obesity and hypertriglyceridemia in Chinese Han population.
25008924 HIV-1 gp120 activates the STAT3/interleukin-6 axis in primary human monocyte-derived dendritic cells.
25008924 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
24997323 Suppression STAT3 signaling is implicated in kurarinol-mediated hepatocellular cell apoptosis.
24973454 STAT3 provides a negative-feedback safety mechanism that limits tissue damage by T helper (Th)17 cells during chronic inflammation, demonstrating that active STAT3 in high density cultures may enhance the formation of IL-17-producing memory T cells.
24969884 Activation of STAT3 protein leads to uncontrolled cell proliferation.
24969755 Data indicate that ubiquitin specific peptidase 22 (USP22)-mediated sirtuin 1 (SIRT1) deubiquitination inhibits STAT3 transcription factor acetylation and its transcriptional activation.
24966947 STAT3 pathway plays an important role in mediating tumor-initiating capacities in nasopharyngeal carcinoma and suggest that inactivation of STAT3 with EGCG may represent a potential preventive and therapeutic approach.
24962868 6SG also suppressed the expression of STAT3-regulated gene products.
24953013 AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers
24946088 The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression.
24945434 FGF2 is required for motor neuron differentiation from human neural stem cells and that inhibition of STAT3 further increases motor neuron differentiation at the expense of astrogliogenesis.
24941337 data presented herein confirmed the occurrence of a redox-dependent regulation of STAT3, identified the more redox-sensitive cysteines within STAT3 structure, and may have important implications for development of new drugs
24939294 Data indicate that fucoidan induces apoptosis through the down-regulation of signal transducer and activator of transcription 3 (p-Stat3).
24932998 Among all women, there was a positive correlation between JAK2 and STAT3 expression
24931456 miR-221 and miR-222 act in a positive feedback loop to increase expression levels of RelA and STAT3 in colorectal neoplasms. Antagonism of miR-221 and miR-222 reduces growth of colon tumors in mice with colitis.
24931262 Data demonstrate that the serum levels of SOCS3 and STAT3 were increased in childhood atopic dermatitis (AD) compared with controls.
24931164 RECK controls this angiogenic rheostat through a novel complex with cell surface receptors to regulate STAT3 activation
24922077 Molecular docking analysis suggested that compound 1 might putatively function as an inhibitor of STAT3 dimerization by binding to the SH2 domain.
24913037 LKB1 is differentially regulated by PRL at the level of transcription in representative human breast cancer cells. Its promoter is targeted by STAT3 and STAT5A, and the cellular estrogen receptor status may affect PRL-responsiveness
24903907 For all the three STAT3 constructs.
24898675 Atopic dermatitis patients showed significantly higher nTreg-cell counts compared to STAT3-hyper-IgE syndromes and control individuals
24892807 CTLA4 expression is observed in T cells of patients with blood malignancies, and CTLA4(apt)-STAT3 siRNA treatment of immunodeficient mice bearing human T cell lymphomas promoted tumor cell apoptosis and tumor growth inhibition.
24891320 binding of STAT3 to a predicted STAT3 binding site upstream of the NKG2D gene is enhanced by IL-10 and IL-21
24891218 These results support STAT3 signaling activity as another functional marker for human breast cancer stem cells.
24886434 Inhibition of the JAK2/STAT3 pathway by the addition of CYT387 suppresses the 'stemness' profile in chemotherapy-treated residual ovarian tumor cells in vitro, which is replicated in vivo, leading to a reduced tumor burden.
24885273 STAT3 rs744166 and rs4796793 polymorphisms may be associated with Crohn's disease occurrence and used as a predictive factor of CD in Chinese Han populations.
24883303 Microvessel morphometry was unrelated to proangiogenic cytokines, p-STAT-3, SOCS-3, or survival
24878845 IL-10 apparently inhibits fibrosis by activating AKT and STAT3 phosphorylation downstream of the IL-10 receptor
24870597 Data indicate that STAT3 transcription factoris a potential target of miR-520a-5p.
24864251 polymorphisms in STAT3, along with environmental factors, might be associated with the development of gastric cancer.
24858640 HPV 16 infection induce upregulation of HER2/neu, pStat3 and IFI16.
24854197 The STAT3 pathway is enhanced during stroke development by IL-32alpha.
24847057 UDP-glucose activates P2Y14 receptor and JAK2, increases STAT3 Tyr705 phosphorylation, and enhances transcription of HAS2.
24843164 We reveal that PTPRD is a bona fide tumor suppressor, pinpoint PTPRD loss as a cause of aberrant STAT3 activation in gliomas, and establish PTPRD loss, in the setting of CDKN2A/p16(INK4A) deletion, as a driver of glioma progression.
24836891 activation of STAT3 induces the expression of GM-CSFRalpha that protects CLL cells from apoptosis, suggesting that inhibition of STAT3 or GM-CSFRalpha may benefit patients with chronic lymphocytic leukemia
24833526 the E3 ubiquitin ligase seven-in-absentia-2 (SIAH2) accelerates the proteasomal degradation of TYK which consequently suppresses the activation of STAT3 in non-small-cell lung cancer
24833467 HPV-16 E2 may regulate NF-kappaB and STAT3 activation in the presence of TNF-alpha with implications on the survival of HPV-infected cells.
24831030 Mahanine suppresses STAT3 activation and promotes ubiquitin-dependent proteasomal degradation of p-STAT3.
24816405 IL-22 Promotes Colon Cancer Stemness via STAT3 Activation
24811707 High STAT3 expression is associated with neuroblastoma.
24806843 Study provides new insight into the regulation of Epithelial-mesenchymal transition by IL-6 via activation of Stat3 in human cervical carcinoma.
24797723 Zerumbone is a novel blocker of STAT3 signaling.
24793791 NPM is a downstream effector of the STAT3 signaling, and can facilitate the nuclear entry of phosphorylated STAT3.
24781989 Our study implies that the STAT3 rs2293152 polymorphism may be associated with the occurrence of UC and might be used as a predictive factor for UC in the Chinese Han population.
24781730 Endothelial cells from aging individuals have impaired angiogenesis and reduced expression of VEGF likely due to impaired nuclear transport of P-STAT3 and P-CREB transcription factors in these cells.
24760274 our results suggest that the activated Stat3 may represent an important mechanism for Beclin 1 downregulation in nonsmall cell lung cancer development
24756126 Stat3 is a novel substrate of the ring-shaped hetero-oligomeric eukaryotic chaperonin, TRiC/CCT, which contributes to its biosynthesis and activity in vitro and in vivo.
24744378 work identifies STAT3 binding long noncoding RNA lnc-DC (LOC645683) that regulates dendritic cell (DC)differentiation; lnc-DC bound directly to STAT3 in the cytoplasm, which promoted STAT3 phosphorylation on tyrosine-705 by preventing STAT3 binding to and dephosphorylation by SHP1
24743237 an essential function of Foxm1 in the LIF/Stat3-mediated mESC self-renewal and the generation of iPSCs
24740453 analysis showed binding of STAT3 to AHSP promoter and binding was significantly augmented with IL6 stimulation and upon alpha-globin overexpression
24737107 IFN-alpha, a member of the type I IFN family, differentially modulates TLR7/8- and TLR9-activated STAT3 and ERK in B cells, which provides an explanation for our findings that IFN-alpha enhances TLR7/8-induced, but not TLR9-induced IL-10 production
24736615 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
24736071 High STAT3 expression is associated with non-small-cell lung cancer.
24732911 Zn deficiency enhances the acute phase response and particularly the JAK-STAT3 pathway, resulting in increased serum amyloid A production.
24726840 Stat3 activity is regulated by CK2 at its phosphorylation Ser-727 residue.
24721162 Compared to wild-type STAT3, the STAT3 R414K/R417K mutant shows attenuated tyrosine phosphorylation and it is a less active transcription factor.
24716848 ERK1/2 as well as STAT3 (Ser727) phosphorylation play an important role in LIF-mediated JEG-3 trophoblastic cell invasion and gene expression
24710357 OSM promotes STAT3-dependent intestinal epithelial cell proliferation and wound healing in vitro.
24708416 IL-17 influences the innate immune system in rheumatoid arthritis by increasing the synovial expression of TLR3 via the STAT3 pathway.
24696730 elevated STAT3 activity in lymph nodes prior to tumor cell arrival may indicate a poorer prognosis in gastric cancer
24687132 STAT3 activity is increased in macrophages following mTOR induction, thus contributing to development of atherosclerosis.
24676554 the present study found that STAT3 (-/p) expression was positively correlated with miR-21 in 60 oral squamous cell carcinoma samples.
24676538 downregulation of LKB1 expression suppresses Stat3 activity that may promote tumor growth during esophageal cancer progression.
24675762 Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activation.
24674241 Data indicate that signal transducer and activator of transcription 3 (STAT3) silenced monocyte-derived dendritic cells promoted a higher interferon gamma production by CD4(+) naive T cells.
24659656 NSCLC cells could be sensitized to cisplatin by targeting STAT3 with chemically modified siRNAs together, a fact which was accompanied with increased apoptosis.
24655440 our results suggest that garcinol exerts its anti-proliferative and pro-apoptotic effects through suppression of STAT3 signaling in HCC both in vitro and in vivo
24652403 data suggest that the pancreatic cancer tumor microenvironment transforms monocytes to monocytic myeloid-derived suppressor cells by STAT3 activation
24652192 STAT3 Tyr705 phosphorylation may have a role in clinical outcome in patients with newly diagnosed supratentorial glioblastoma
24643836 Phosphorylated STAT3 and PD-1 regulate IL-17 production and IL-23 receptor expression in Mycobacterium tuberculosis infection.
24642471 IL-6R/STAT3/miR-34a feedback loop was present in primary colorectal tumors as well as CRC, breast, and prostate cancer cell lines and associated with a mesenchymal phenotype.
24639502 STAT3 interrupts ATR-to-Chk1 signaling by promoting loss of Claspin, a protein that assists ATR to phosphorylate Chk1.
24627483 Data indicate that proteasomal subunit X PSMB5 is a target of signal transducer and activator of transcription 3 (STAT3).
24627437 Studied a new therapeutic alternative in the treatment of multiresistant lung adenocarcinoma via siRNA-specific transfection of six crucial molecules involved in lung carcinogenesis: SFR, E2F1, Survivin, HIF1, HIF2 and STAT3.
24615012 A functionally distinct, noncanonical STAT3 phosphoform positively regulates target gene expression in a combinatorial signaling context.
24610393 overexpression of hsa-miR-4516 downregulates STAT3, p-STAT3, CDK6, and UBE2N proteins that are consistently upregulated in psoriasis and induces apoptosis in HaCaT cells.
24590058 Cell survival under unstressed conditions is due to cell type-specific autophagy regulation of STAT3 activity.
24583285 The promoter of the miR-17-92 gene cluster is transactivated through the promoter binding of STAT3 while BIM expression is decreasesed during Toxoplasma gondii infection.
24582310 Mitochondrial STAT3 plays a major role in IgE-antigen-mediated mast cell exocytosis.
24577500 In conclusion, here we show that STAT3 activation can be one of the molecular mechanisms leading to KSHV-mediated DC dysfunction, that might allow viral persistence and the onset of KSHV-associated malignancies.
24577086 Inactivation of Stat3-Bcl-2 pathway contributes to metformin-induced growth inhibition of esophageal squamous cell carcinoma by facilitating crosstalk between apoptosis and autophagy.
24569879 findings reveal unique structural characteristics of STAT3 within the STAT family and contribute to the understanding of the L78R mutation found in inflammatory hepatocellular adenoma
24551293 IL-6/JAK/STAT3 signaling pathway is active and may play an important role in the mechanisms of epithelial hyper-proliferation responsible for cholesteatoma.
24551274 NOX1 is involved in acure respiratory distress syndrome pathophysiology and is responsible for the damage occurring in alveolar epithelial cells at least in part via STAT3 signalling pathways.
24550541 STAT3 bound to previously undescribed negative regulatory elements within the promoter of PRKCB, which encodes PKCbetaII.
24550394 Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-beta (TGF-beta) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.
24533098 RhoC has a role in regulating cancer stem cells in head and neck squamous cell carcinoma through the over expression of IL-6 and phosphorylation of STAT3
24519067 downregulation of STAT3 or Survivin can suppress the proliferation of T24 bladder cancer cells.
24518302 STAT3 and NFkappaB synergistically act for maximum induction of FAT10 expression.
24512550 activating mutations specific for large granular lymphocytic leukemia [review]
24511136 Our data indicate the presence and involvement of Stat3/STAT3-dependent Treg17 cells that specifically target Th17 cells in murine and human crescentic glomerulonephritis.
24499623 These findings may provide a novel linkage between the EGFR and STAT3 signaling pathways and the activation of cyclin D1 by LMP1 in the carcinogenesis of NPC.
24497534 Data show that T-cell transcription factor GATA-binding protein 3 (GATA-3) expression identifies a subset of T-cell lymphomas PTCL, NOS with a distinct cytokine profile and inferior survival.
24496235 This mitoStat3-mtDNA interaction may represent an alternate signaling pathway that could alter mitochondrial function and biogenesis and have a role in tumorigenesis.
24491408 study thus identified a mechanism by which STAT3 signaling can be inhibited in pancreatic cancer cells by modifying let-7 expression
24483027 Inhibition of the STAT3 gene decreases HeLa cell migration, moreover the blocked STAT3 ability to the antyapoptotic gene expression activation leads to the increased susceptibility to apoptotic cell death.
24481815 Association of MCL-1 with STAT3 modulates the normal, anti-apoptotic, activity of MCL-1, resulting in pro-apoptotic effects.
24476004 Loss of SOCS3 increased tumor growth, migration, and invasion and resulted in accompanied changes in expression of STAT3 and its target oncoproteins.
24473398 Signal transducers and activators of transcription 3 suppression by JMJD2B silencing enhanced DNA damage.
24473196 higher expression of miR-146b was positively correlated with patient survival in breast cancer subtypes with increased IL6 expression and STAT3 phosphorylation.
24472656 data support the existence of a signaling cascade by which stimulation of macrophages with the IL-10 cytokine determines a sequential activation of STAT3 and MafB transcription factors
24472538 Blockage of Stat3 with a selective inhibitor, S3I-201, or siRNA presents an effective strategy to overcome resistance to PI3K/Akt/mTOR inhibition in non small-cell lung cancer cells.
24462277 Core is capable of up-regulating NANOG expression
24460100 genetic association studies in Croatian population: Data suggest that an SNP in STAT3 (rs744166) is not associated with susceptibility to or severity of Hashimoto's thyroiditis in the population studied. [PILOT STUDY]
24455684 our results suggest a previously unknown Stat3-LGR4 molecular network, which may control osteosarcoma development and progression
24450414 We propose that the natural compound 2-MS, as a potent dual inhibitor of STAT3 and NF-kappaB pathways, is a promising anticancer drug candidate.
24448750 NF-kappaB and STAT3 signaling pathways, as main inflammatory mediators, are found to be activated in urothelial bladder carcinoma.
24435707 We demonstrate a mechanism by which EGF promotes prostate cancer cell progression through a ROS/STAT3/HIF-1alpha/TWIST1/N-cadherin signaling cascade, providing novel biomarkers and promising therapeutic targets for prostate cancer cell progression.
24431073 these data demonstrate that XPO1 inhibition by SINE compounds represses STAT3 transactivation to block the selective oncogenic properties of survivin and supports their clinical use in triple-negative breast cancer .
24402583 vOur study clearly demonstrates that the predominant effect of this combination is the reduction of signaling molecules including STAT3, STAT5b, IGF-1R, VEGF and VEGF-R2 which are involved in the growth, progression and metastasis of human bladder cancer
24401319 in this work, we identified TPCA-1 as a direct dual inhibitor for both IKKs and STAT3, whereas treatment targeting EGFR only could not sufficiently repress NF-kappaB and STAT3 pathways for lung cancers harboring mutant EGFR
24395800 tumor-specific mutational events in the PTPRT gene can serve as direct drivers for tumor growth by inducing hyperactivation of STAT3, a potent oncogenic transcription factor and PTPRT substrate
24392029 Syndecan-1 modulates the cancer stem cell phenotype via regulation of the Wnt and IL-6/STAT3 signaling pathways
24390815 (E)-2,4-Bis(p-hydroxyphenyl)-2-butenal enhanced TRAIL-induced ovarian cancer cell apoptosis via NF-kappaB/STAT3 signaling.
24390735 HAVCR/KIM-1 activates the IL-6/STAT-3/HIF-1A axis.
24388873 This review presents the evidence for critical roles of STAT3 in oncogenesis and discusses the potential for development of novel cancer therapies based on mechanistic understanding of STAT3 signaling cascade.
24386409 STAT3 may affect astrocytoma invasion, expression of pSTAT3(Tyr705) is a significant prognostic factor in tumor recurrence and overall survival in astrocytoma patients.
24386318 activation of STAT3 signaling leads to regulation of hTERT pathway
24382554 It has been shown that rs3816769 STAT3 gene polymorphisms are associated with Nonsmall cell lung cancer susceptibility and might be regarded as having a significant functional and diagnostic value.
24376686 The EGFRvIII-STAT3 pathway promotes cell migration and invasion by upregulating S100A11 in hepatocellular carcinoma.
24376586 These studies demonstrate an important role for STAT3 signaling in ALDH(+) and ALDH(+)/CD44(+)/CD24(-) subpopulations of breast cancer cells.
24374144 The level of p-Stat3 was found to be higher in imatinib therapy resistant cases of chronic myeloid leukemia than in responsive cases, which suggest the beneficial use of p-Stat3 as an indicator to follow the clinical course and the treatment response.
24362463 These findings uncover a novel mechanism of radioresistance and provide a more effective approach to overcome radioresistance by blocking the STAT3/Bcl2/Bcl-XL survival signaling pathway.
24350896 The SH2 domain of the STAT3 gene is frequently mutated in Asian T-cell large granular lymphocytic leukemia and chronic lymphoproliferative disorders of natural killer cells.
24344100 The secretome of senescent melanoma cells activates the STAT3 pathway and STAT3 inhibition prevents secretome effects, including the acquisition of tumorigenic properties.
24342613 Hes1-mediated enhancement of IL-22-STAT3 signaling significantly increased the induction of genes encoding antimicrobial peptides, such as REG1A, REG3A and REG3G, in human intestinal epithelial cells.
24341525 A panel of miRNAs is regulated through promoter binding of the STAT3 in human macrophage and these miRNAs are involved in anti-apoptosis in response to T. gondii infection.
24338929 Data indicate that CTLA4Fc fusion protein activates STAT3, which is critical for dendritic cells (DCs) function.
24332948 STAT3 protein expression is a strong indicator of poor prognosis and survival of patients diagnosed with non-small-cell lung cancer. phospho-STAT3(review)
24328557 Targeted blockade of the STAT3 signaling pathway with a decoy oligodeoxynucleotide may represent a potential therapeutic approach in the treatment of ovarian cancer.
24327257 CD24 mediates gastric carcinogenesis and may promote GC progression by suppressing apoptosis and promoting invasion, with the activation of STAT3 playing a critical role.
24315995 FoxP3 promotes transcription in association with the locus-specific transcription factor STAT3
24312439 study shows that the MEK-ERK pathway is required for activated Ras-induced phosphorylation of STAT3 on S727, that inhibition of STAT3 S727 phosphorylation contributes to the anti-oncogenic potential of MEK inhibitors
24307657 The autocrine IL-6 pathway induces enzalutamide resistance in prostate cancer cells via the constitutive activation of Stat3.
24289584 IL-21 signals through the STAT-3 and STAT- 5b signaling pathway in the CIK cell pool.
24287565 Restored STAT3 expression through treatment with IL-6 cytokine partly abolished miR-124-mediated cell cycle arrest and apoptosis induction.
24283217 Results demonstrate the remarkable correlation of STAT3 mutation with PRCA, neutropenia and ss2-MG.
24280348 Authors have discovered a STAT3-dependent Akt activation that impairs the efficacy of gefitinib.
24266654 STAT3 activity regulates the cycling of quiescent dental pulp stem cells to determine their fate.
24260381 Scoparone might bind the SH2 domain of STAT3.
24244348 TNF-alpha-induced activation of NF-kappaB is sufficient to induce IL-6 expression, activate STAT3, and elevate STAT3 target gene expression in GBM cell lines and human GBM xenografts in vitro.
24243860 The Multiple myeloma samples seemed to show elevated basal level of Stat3 phosphorylation.
24218138 In contrast to naive B cells, STAT3-deficient memory B cells responded to STAT3-activating cytokines, differentiating into plasmablasts and secreting high levels of IgM, IgG, and IgA, as well as Ag-specific IgG.
24211205 these findings show that miR-124 functions as tumor suppressor in hepatocellular carcinoma (HCC) by targeting STAT3, and miR-124 may therefore serve as a biomarker for diagnosis and therapeutics in HCC.
24199193 In this paper, we first describe the mechanism of STAT3 regulation followed by how STAT3 is involved in cancer metastasis, then we summarize the various small molecule inhibitors that inhibit STAT3 signaling.
24192393 that miRNAs represent a newly discovered class of regulatory molecules, investigating their biological functions and contribution to pathologies caused by STAT3 dysregulation is essential to improve our understanding of tumorigenesis
24192293 Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain
24191246 Thus, our results suggest a previously unknown Stat3-PTPN13 molecular network controlling squamous cell lung carcinoma development
24184145 mutation is associated with diminishes rates of food allergies and anaphylaxis in patients with autosomal-dominant hyper-IgE syndrome
24178245 This study has confirmed that adrenocortical carcinoma overexpress signal transducer and activator of transcription 3 and insulin-like growth factor 2
24177177 An opposing role of AR and STAT3 in prostate Cancer stem-like cell development.
24173212 findings simultaneously reveal how EBV manipulates host STAT3 even before expression of viral oncogenes to facilitate cell survival and proliferation, processes fundamental to EBV lymphomagenesis
24164699 investigation of STAT3 tyrosine-705 phosphorylation and its correlation with its possible regulator HER2 in the prognosis of pancreatic ductal carcinoma
24159173 Data indicate that IL-21 induces IL-2RA (CD25) in normal, but not STAT3-deficient, naive B cells.
24158981 KIM-1 expression increased significantly in a manner that corresponded temporally and regionally with increased phosphorylation of checkpoint kinase 1 (Chk1) and STAT3 in acute kidney injury.
24157808 results of the activation and varying localisation of STAT3 and its phosphorylated form in nasal polyps suggest that pSTAT3 plays a crucial role in the proliferative development of nasal polyps
24142927 STAT3 is overexpressed and overactive diffuse large B-cell lymphoma and STAT3 binding associates with oncogenic pathways.
24140557 Porphyromonas gingivalis modulates Pseudomonas aeruginosa-induced apoptosis of respiratory epithelial cells through the STAT3 signaling pathway.
24135280 EGF, EGFRvIII, STAT3 and STAT5 have roles in progression of glioblastoma
24135245 Review of the contribution of STAT3 to lung cancer growth and progression. [Review]
24132924 We identified HAb18G/CD147 as a novel upstream activator of STAT3, which interacts with CD44s and plays a critical role in the development of pancreatic cancer.
24129709 Cross-talk between KLF4 and STAT3 regulates axon regeneration.
24127267 these findings provide new evidence for a positive feedback loop between STAT3 signaling and COX-2 in H. pylori pathogenesis
24123009 Confluence of cultured lung cancer cells dramatically increases STAT3 activation independent of SRC action.
24122993 Ursolic acid inhibits persistently activated STAT3 in cancer stem cells, indicating that STAT3 is a new target for colon cancer prevention.
24117170 determined whether activation and expression levels of EGFR1, ERK, AKT, STAT3, and TWIST1 are dependent on activating mutations of EGFR1 in NSCLC
24116074 Increased IL-6-induced activation of STAT3 was observed in neoplastic gastric tissue, which positively correlated with tumor progression.
24114793 Human metapneumovirus infection inhibits the phosphorylation and nuclear translocation of STAT3.
24114327 Data indicate that the IL-32beta-VEGF-STAT3 pathway affects the migration of MDA-MB-231 cells.
24107450 Targeting blockage of STAT3 in hepatocellular carcinoma cells augments NK cell functions via reverse hepatocellular carcinoma-induced immune suppression.
24101550 STAT-3 activation is critical for human plasma cells throughout their maturation.
24082147 Newly synthesized IL-6 drives association of the IL-6 receptor and gp130 with EGFR, leading to EGFR-dependent rephosphorylation of STAT3, which is not inhibited by the continued presence of SOCS3.
24081513 association between STAT3 SNPs and autoimmune thyroid disease was found in chinese patients.
24067369 HIC1 interacts with and modulates the transcriptional activity of STAT3.
24065300 our research data indicate that the anticancer function of green tea results from the inhibition of the STAT3 signaling pathway by EGCG.
24064760 SIRT1-specific short-interfering RNA was used to investigate the role of SIRT1 in STAT3 signaling
24055735 Studied the cytotoxic effect of NO donors on ovarian cancer cell lines, as well as their effect on posttranslational modification of STAT3 and AKT proteins in these cells.
24054889 Data suggest HLA-G antigen regulates invasiveness of choriocarcinoma cells and invasiveness of trophoblasts at blastocyst implantation; down-regulation of HLA-G dampens STAT3 activation; up-regulation of HLA-G promotes STAT3 activation/invasiveness.
24052949 Expansion of myeloid-derived suppressor cells (MDSCs) by mesenchymal stromal cells (MSC)-secreted HGF involves c-Met (its receptor) and downstream phosphorylation of STAT3, a key factor in MDSC expansion.
24048798 RKIP and STAT3 have an additive effect on the survival of high-grade glioma.
24040078 targeted by miR-130b, which was further confirmed by the inverse expression of miR-130b and STAT3 in pancreatic cancer samples.
24037855 Gankyrin is crucial for cholangiocarcinoma carcinogenesis and metastasis by activating IL-6/STAT3 signaling pathway through down-regulating Rb protein.
24036113 results suggest a two-step mechanism, whereby LfcinB induces TIMP-1 through an IL-11-dependent pathway involving transcription factor AP-1 and STAT3.
24029664 Data indicate that supraglottic laryngeal tumor cell lysates (SLTCL) mediated macrophage polarization is STAT3 dependent.
24028796 The STAT3 completely abrogated the anti-apoptotic effect and expression of caspase3 in decidual gammadelta T cells induced by human TSLP.
24027425 Our data suggest that epithelial STAT3 plays a critical role in inflammation-induced tumor progression through regulation of leukocytic recruitment especially the infiltration of Treg cells in the large intestine.
24025152 Knockdown of STAT3 causes a significant reduction in tumor burden and delays tumor progression with increased response to gemcitabine.
24015205 STAT3 is an important downstream mediator of the pro-carcinogenic effects of PRKCZ in pancreatic cancer cells.
24013128 Analysis of the STAT3 interactome using in-situ biotinylation and SILAC.
24005672 The total CTGF production induced by TGF-beta in activated HSCs is therefore, to a large extent, dependent on the balance and integration of the canonical Smad3 and Stat3 signaling pathways
24005169 the role of pSTAT3 in temporal bone squamous cell carcinoma warrants further investigation because there is increasing evidence in preclinical models that inhibiting STAT3 phosphorylation can be a useful addition to different anticancer strategies.
24004609 Interleukin-6 up-regulates miR-21 levels via activating STAT3 in HBE cells exposed to arsenite.
23995109 Stat3 activation in lymphoma cells was involved in this cell-cell interaction.
23991153 results demonstrate the role of IL-6-STAT3 signaling in ACS through increased Th17 cell differentiation
23991099 RNA Pol II on HIF1 or HIF2 target genes is primarily associated with HIF1alpha or HIF2alpha in a STAT3 or USF2 dependent manner
23984931 Probucol could attenuate tert-butyl hydroperoxide induced mesangial cell senescence by regulating JAK2/STAT pathway.
23982944 Molecular mechanism dissection revealed that targeting prostate cancer cell AR with siRNA promoted cell migration/invasion via CCL2-dependent STAT3 activation and epithelial-mesenchymal transition pathways.
23975180 STAT3-mediated activation of microRNA cluster 17~92 promotes proliferation and survival of ALK-positive anaplastic large cell lymphoma.
23971732 suppression of STAT3 during brain inflammation would inhibit astrogliogenesis and promote neurogenesis.
23967200 Activated STAT3 binds to the MMP3 promoter region and regulates MMP3 in Heme-induced endothelial cell apoptosis.
23966384 These findings place STAT3 at a critical crossroads between Epstein-Barr virus latency and lytic activation, processes fundamental to Epstein-Barr virus lymphomagenesis.
23962558 Findings indicate the important role of Stat3 in cisplatin resistance in ovarian cancer.
23953057 Data indicate a mechanism that fibroblast senescence promotes cervical cancer development through high-risk HPV16 and HPV18 E6-activated IL-6/STAT3 signalling in tumour microenvironment.
23950992 Data indicate that IL-6- and IFN-alpha-induced STAT3 phosphorylation and IFN-alpha-induced STAT1 phosphorylation were impaired in plasmacytoid dendritic cells (pDCs) from Crohn's disease (CD) patients.
23943785 Stat signaling and VEGF expression are inhibited by the antiangiogenic plant flavone acacetin
23941877 Data suggest that in prostate cancer cells CDK5 (cyclin-dependent kinase 5) regulates interaction of STAT3 with AR (androgen receptor) through phosphorylation of Ser727-STAT3 and thereby up-regulates AR protein stability.
23941832 Data indicate that ruxolitinib effectively inhibited JAK/STAT signalling in hepatocellular carcinoma (HCC) cells with a significant reduction in the expression of JAK downstream targets pSTAT1 and pSTAT3.
23936533 STAT3 activation promotes oncolytic HSV1 replication in glioma.
23926297 STAT3-mutant Large granular lymphocyte leukemia clones may be responsible for the primary induction of bone marrow failure in a subset of aplastic anemia and myelodysplastic syndromes patients
23923047 The acquisition of B cell stimulating properties by naive cord blood CD4 T cells required the STAT3-dependent expression of ICOS and IL-21.
23920124 Data indicate that the anti-tumor effects of guggulsterone (GS) possibly involve multiple networks including inhibition of FAK, Src, and Jak/STAT signaling.
23919497 zinc transporter ZIP6 is transcriptionally induced by STAT3 and unprecedented among zinc transporters, and is activated by N-terminal cleavage which triggers ZIP6 plasma membrane location and zinc influx.
23912451 STAT3 knockdown reduces cell proliferation.
23911788 expression level of nuclear JAB1, but not nuclear STAT3, correlated with unphosphorylated STAT3 DNA-binding activity between COLO205 and LoVo cells
23907460 The signaling cross point of the mitochondrial pathway and the JAK2/STAT3 signaling pathway in C6 glioma cell death is modulated by quercetin-nanoliposomes.
23904224 IL-18 induces profibrotic cellular changes and collagen production in renal tubular epithelial cells via STAT3 activation.
23902772 The constitutive activation of STAT3 and NF-kappaB signaling pathways that leads to the regulation of Notch pathway genes in glioma CSCs identifies novel therapeutic targets for the treatment of glioma.
23900445 Variations in genes AGRP, CPE, GHRL, GLP1R, HTR2A, NPY1R, NPY5R, SOCS3 and STAT3 showed modest associations with BMI in European Americans.
23894143 These findings uncover a novel mechanism of erlotinib resistance and provide a novel approach to overcome resistance by blocking the STAT3/Bcl2/Bcl-XL survival signaling pathway in human lung cancer
23880305 The combination of antrocin and JAK2/STAT3 gene silencing significantly increased apoptosis in H441 cells.
23874455 STAT3 plays a regulatory role in HPV16-mediated cervical carcinogenesis.
23861822 A novel missense (M206K) STAT3 mutation in diffuse large B cell lymphoma deregulates STAT3 signaling.
23857432 inhibition of IGF-IR and targeting of the JAK2/STAT3 signaling pathway can be a target for ovarian cancer therapy.
23856509 miR-124 was down-regulated specifically in colon tissues from pediatric patients with ulcerative colitis and directly targeted STAT3 messenger RNA
23848338 Emodin mediated its effects predominantly through inhibition of the STAT3 signalling cascade and thus has a particular potential for the treatment of cancers expressing constitutively activated STAT3.
23841503 The miR-1234 expression level correlated inversely with the expression of STAT3. The Stat3 protein was down-regulated in cells transfected with miR-1234, suggesting that STAT3 might be a potential target for miR-1234.
23838996 In tumor cells, STAT-3 knockdown inhibited VEGF but not HIF-1alpha expression. HIF-1alpha overexpression increased STAT-3 expression and this was inhibited by ganetespib
23830147 The IL-21R/STAT3 pathway is required for many aspects of human CD8(+) T-cell behavior but in some cases can be compensated by other signals.
23824571 Data indicate that SOCS-3, STAT-3, and the status of extragastric nodal metastasis were identified to be the independent factors of the lymph node metastasis from gastric cancer (GC).
23824569 Activation of the EGFR/STAT3 signaling pathway may contribute to lymph node metastasis, which can promote the progression of gastric cancer.
23820254 The STAT3-induced miR-92a promotes cancer invasion by suppressing RECK.
23817566 High STAT5 expression is associated with pancreatic cancer.
23813018 Higher expression of p-p38, p-C-JUN, p-STAT3, and p-gp130 in the MBC-B group.
23807222 Stat3 inactivation and Skp2 degradation regulate cell death pathways in tumor cell lines treated with salinomycin.
23796786 mutation results in impaired host defense against Candida and staphylococci in hyper-IgE syndrome patients
23791019 Our results revealed a novel role of Epstein-Barr virus encoded small non-cdoing RNAs (EBERs) in the coordination of IL-6-STAT3 signaling pathway to chemoresistance and cellular migration in cancer cells.
23788661 results suggest that (i) STAT3 is required for the maintenance of the latent state and interference with its functions leads to reactivation and (ii) p300/CBP is essential for HSV reactivation
23782265 Data suggest that flavanoids (naringenin, flavone) suppress STAT3 signaling and induce expression of SOCS3 (suppressor of cytokine signaling 3) in cultured vascular endothelial cells; thus, dietary components can act as anti-inflammatory agents.
23771657 We therefore conclude that germacrone induces apoptosis through the JAK2/STAT3 signalling pathway.
23768868 Single nucleotide polymorphisms in STAT3 is associated with non-Hodgkin lymphoma.
23756862 strong STAT3 expression in surgical specimens was correlated with an increase in median colorectal cancer overall survival by about 30 months
23750211 STAT3 activates miR-155 in chronic lymphocytic leukemia cell
23741012 these data indicate a direct role for TEL-AML1, via increasing the activity of RAC1, in regulating the phosphorylation of signal transducer and activator of transcription 3 (STAT3), which results in transcriptional induction of MYC.
23740979 Kaposin B significantly contributes to the chronic inflammatory environment by unique activation of the proto-oncogene STAT3, coupled with MK2-mediated inactivation of the STAT3 transcriptional repressor TRIM28.
23736381 the expression of Oct-4, Nanog, Sox-2 and Stat-3 are related to differentiation in ameloblasts and odontoblasts.
23734190 Findings indicate a role of B cells in promoting tumor progression through angiogenesis and identify STAT3 in B cells as potential therapeutic target for anti-angiogenesis therapy.
23725032 The presence of activated STAT3 has a profound effect on miR expression in CLL cells.
23716595 STAT3 increases expression of BCL6 and enhances recruitment of RNA polymerase II phosphorylated at a site associated with transcriptional initiation.
23708661 Results suggest that LPLUNC1 can inhibit inflammation and nasopharyngeal carcinoma (NPC) growth by downregulating the Stat3 pathway.
23704922 Elevated levels of IL-26 in human gastric cancer promote proliferation and survival by modulating STAT1/STAT3 signaling.
23703790 STAT3 plays a role in the life cycle of HCV and have clarified the role of STAT3 as a proviral host factor.
23693134 Variant G6PD levels promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in the human melanoma xenograft mouse model.
23681230 STAT3 binds indirectly in complexes with NF-kappaB to the GADD45G promoter.
23677069 these results define a novel signaling network whereby JAK2/STAT3 signaling creates a feed-forward loop to raise activated WASF3 levels that promote cancer cell motility.
23676499 AGK expression was significantly correlated with JAK2/STAT3 hyperactivation in esophageal squamous cell carcinoma, as well as in lung and breast cancer.
23674871 IL-22/STAT3 signaling pathway may be related to ulcerative colitis and UC-induced carcinogenesis and IL-22 can be used as a biomarker in judging the severity of UC.
23673666 Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor.
23665320 Positive expression rate of IL-6/STAT3 was 39.7% (23/58)/29.3% (17/58) in primary Wilms' tumor tissues, while 61.1% (11/18)/33.3% (6/18) in associated invasive/metastatic tissues.
23665025 Taken together, these results suggest that the pharmacological inhibition of STAT3 may be a promising therapeutic strategy for the management of chemoresistance in ovarian cancer.
23659370 These results suggest that not all patients with Hyper-IgE syndrome who had NIH scores over 40 points carry STAT3 mutations, those whose Th17 cell numbers strikingly decreased probably had autosomal dominant Hyper-IgE syndrome with STAT3 mutations.
23653350 Data indicate that metastatic breast cancer (BC) cells that failed to activate STAT3 downstream of EGFR did display robust STAT3 activity upon adhesion to fibronectin (FN).
23650499 Inhibition of the STAT3 pathway by phosphor-valproic acid inhibits pancreatic cancer growth in mice.
23639951 Stat3 is an independent risk factor for subsequent thrombosis during follow-up.
23636231 Among signaling pathways that regulate Mcl-1 gene expression, only constitutive STAT3 phosphorylation was suppressed by chrysin.
23636127 miR-124 expression is significantly reduced in glioblastoma and inhibits STAT3.
23633489 An interaction between neuroblastoma cells and their microenvironment is mediatwed by the IL-6-STAT3 pathway.
23628554 High STAT3 expression is associated with acute myeloid leukemia.
23624919 STAT3 signaling and invasion in human melanoma cell lines is regulated by mitogen-activated protein kinase (MAPK) signaling
23623921 TGF-beta1 up-regulates STAT3 activation and HIF-1alpha stabilization, which leads to TWIST1 expression in a prostate cancer invasion cascade
23622344 Leptin may be one of the proinflammatory cytokines that up-regulates IL-6 production in rheumatoid synovial fibroblasts via activation of JAK2/STAT3.
23618357 Down-regulation of GRIM-19 is associated with STAT3 overexpression in breast carcinomas.
23614738 STAT3 is activated at two phosphorylation sites: Tyr705 and Ser727, and both phosphorylation sites were phosphorylated in lesional psoriatic skin.
23613996 Stat3 downstream gene product chitinase 3-like 1 is elevated in lung cancer
23612802 reciprocal crosstalk between the MAPK pathway and STAT3-mediated signal transduction forms a critical axis successively activated by lipopolysaccharides in bladder epithelial cells.
23612755 STAT3 phosphorylation was activated more in the GBM-SC lines than serum-derived GB cell lines
23604529 acetylated STAT3-induced promoter gene methylation accounts for the loss of ARHI expression and cancer cell proliferation.
23604114 STAT3 works with HIF1 to activate HIF1 target genes and to drive HIF1-depedent tumorigenesis under hypoxic conditions, but also has HIF-independent activity in normoxic and hypoxic cells.
23599149 ALK-positive large B-cell lymphomas express a complete plasmablastic differentiation program but unlike plasmablastic lymphomas do not have MYC rearrangements. STAT3 is constantly activated and may be an alternative mechanism to promote MYC expression.
23591770 The IL-6/STAT3 signalling loop and platelet-derived growth factor-BB (PDGF-BB)/PDGF receptor (PDGFR) pathway were important for CM-induced cell migration and invasion.
23590999 Expression of STAT3 protein in 80 thymic epithelial tumors was detected by immunohistochemistry. Positive expression of STAT3 protein was associated with Masaoka staging and WHO histological classification, but not with age, gender, or tumor size.
23590971 Results suggest that the Fas signal favors the Th17-phenotypic features of T cells through the caspase-1/Stat3 signaling pathway.
23583378 STAT3 directly bound to the STAT3 binding site on the nm23-H1 promoter and activated its expression
23573315 Androgen-STAT3 activation may contribute to gender disparity in human simply renal cysts.
23563237 STAT3 mutations are frequent in CD30 positive T-cell lymphomas and T-cell large granular lymphocytic leukemia.
23555719 HCMV activated the IL-6-JAK-STAT3 pathway in PHH and HepG2 cells
23555696 the influence of STAT3 on the IL-17A/IFN-gamma -mediated RNase 7 induction
23554973 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
23548897 Knocking down BV8 in human myeloid leukemia cells inhibits STAT3 activity and expression of STAT3 downstream angiogenic and pro-proliferation/survival genes.
23545262 siRNA-mediated knockdown of DAPK1 attenuated the curcumin-induced inhibition of STAT3 and NF-kappaB. Moreover, DAPK1 suppression diminished curcumin-induced caspase-3 activation.
23533997 alantolactone-induced apoptosis was found to be associated with GSH depletion, inhibition of STAT3 activation, ROS generation, mitochondrial transmembrane potential dissipation, and increased Bax/Bcl-2 ratio and caspase-3 activation
23531921 Data suggest that inhibition of the JAK/STAT3 signal transduction could be a promising therapeutic target for high-risk pediatric solid tumors.
23531596 Data indicate that STAT3 physically interacted with progesterone receptor (PR)-A, which is known to be important for uterine development and function, but not with PR-B.
23526220 metformin suppresses STAT3 activation via LKB1-AMPK-mTOR-independent but ROS-related and autocrine IL-6 production-related pathways. Thus, metformin helps to overcome tumor drug resistance by targeting STAT3.
23514705 Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner.
23504318 STAT3-mediated coincidence detection regulates noncanonical immediate early gene induction.
23496892 antibody behaves like a potent non-competitive inhibitor blocking IL-21 induced STAT3 phosphorylation for a long period of time. These results may help with the translation of preclinical information and dose selection towards ATR-107 clinical efficacy
23483208 HBx upregulates the Bax/Bcl-2 ratio by activating the JAK2/STAT3 signaling pathway.
23461823 Interactions between M2 macrophages and endometrial stromal cells via Stat3 activation may play an important role in the development of endometriosis.
23455323 Suppression of STAT3 activity disrupted B-RAF(V600E)-mediated induction of Mcl-1.
23454751 The tumor suppressive function of arginase-I in both infiltrating and circulating myeloid-derived suppressor cells is a downstream target of activated STAT3.
23446809 Phospho-STAT3 is a marker of favorable outcome in breast cancer patients treated with adjuvant chemotherapy.
23438478 a new function of DAPK in suppressing TNF-induced STAT3 activation, was identified.
23437123 overexpression of miR-155 inhibited SOCS1expression, elevated STAT3 expression, and promoted hep-2 cells growth, migration and invasion.
23434585 Data indicate that the mode of binding that is similar to that known for the STAT3 core phosphorylated at Y705.
23421940 Our data demonstrate that STAT3 is critical in IL-17-induced survival of fibroblast-like synoviocytes from rheumatoid arthritis patients.
23416975 STAT3 induces PTTG expression to facilitate tumor growth and metastasis.
23416296 ECHS1 specifically represses STAT3 activity and negatively regulates the expression of several target genes of STAT3 through inhibiting STAT3 phosphorylation.
23408403 None of the single nucleotide polymorphisms of either TYK2 or STAT3 was statistically associated with the susceptibility to CD in our local population (P > 0.05).
23406316 stimulatory effect of ADSC conditioned media or IL-6 was accomplished through activation of both STAT3 and MAP kinse signaling pathways
23403044 Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency.
23402362 NF-kappaB and STAT3 are positively associated and synergistically contribute to the metastatic potential of gastric cancer cells.
23391827 a novel STAT3 non-consensus TFBS at nt -75/-66 downstream of the NF-kappaB RE in the SAA1 promoter region that is required for NF-kappaB p65 and STAT3 to activate SAA1 transcription
23386605 Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis
23386590 SNPs appear to predispose the host with hepatitis B virus mutations to hepatocarcinogenesis.
23378274 Data indicate that galectin-4 elicits tumor promotion in vitro and in vivo through activation of IL-6/NF-kappaB/STAT3 signaling.
23376640 Suggest that CCK2R-mediated COX-2 up-regulation via JAK2/STAT3/PI3K/Akt pathway is involved in the proliferative effect of gastrin on human gastric cancer cells.
23364389 STAT3 activation was correlated with aggressive behavior of hepatocellular carcinoma and may be mediated via tumor-associated macrophage
23361365 C-reactive protein expression and STAT3 activation are reduced in docosahexaenoic acid and eicosapentaenoic treated HepG2 cells.
23351302 Inhibition of STAT3 activation abolished the wound fluid response, showing that STAT3 plays an important role in the wound healing response.
23340171 show that these events can be at least in part attributed to the STAT3/Survivin pathway
23333463 The depletion of STAT3 inhibited the ability of cells to migrate and invade, and impaired the cellular cytoskeleton mainly microtubules
23333300 Stat3 inhibits WTX expression through up-regulation of micro RNA-370 in Wilms tumor.
23329056 RAD001 might have the capacity to induce megakaryocytic differentiation through the up-regulation of STAT3 signalling
23326583 ATPgammaS induced COX-2 expression and PGE(2) production via a P2 receptor/PKC/NADPH oxidase/ROS/Jak2/STAT3/cPLA(2) signaling pathway in A549 cells.
23326564 The present study identifies STAT3 as an important signaling molecule interacting with CD44 and demonstrates the essential role of CD44-STAT3 signaling in breast cancer invasion
23322822 Malignant pheochromocytoma overexpress HSP90 and STAT3.
23322197 Upregulation of Stat3 is associated with gastric adenocarcinogenesis.
23318430 reducing EGFR activity strongly reduced pSTAT3 in vivo
23317146 our results suggest that STAT3 exon 21 mutation is rare in most human cancers
23303450 IL-6 trans-signaling-STAT3 pathway may have an integral role in hypertrophic scar pathogenesis.
23295773 Activation of STAT3 is associated with glioblastoma multiforme.
23288901 the unphosphorylated form of STAT3 binds to regulatory regions of proapoptotic genes and prevents their expression in tumor cells but not normal cells
23274199 Data indicate that tocilizumab enhanced the interferon-induced phosphorylation of STAT1 and inhibited SOCS3 expression and the phosphorylation of both STAT3 and ERK.
23271731 import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain
23266857 These data demonstrate a nontranscriptional activity of STAT3 that facilitates a crosstalk between proinflammatory cytokine and hemostasis/thrombosis signals in platelets.
23253440 Data indicate that active cruzipain completely abrogated the STAT3 phosphorylation and enzymatically cleaved gp130 ectodomain.
23250732 High DARPP32/STAT3, DARPP32/STAT5B, and STAT5B/STAT3 ratios were associated with longer patient progression free survival.
23246576 Xanthohumol is a potent antineoplastic chemo- and radio-sensitizer, and its actions are mediated through STAT3 and EGFR inhibition.
23243289 examined Stat3 and Stat5 activation patterns in resting and ligand-stimulated primary samples from pediatric patients with acute myeloid leukemia
23228483 Leptin increases HER2 levels by inducing a STAT3-mediated Hsp90 expression in breast cancer cells.
23226414 The present study investigates the involvement of the IL-6 family of cytokines, activation of the transcription factor STAT3 and the role of SOCS3 in regulating excitotoxic neuronal death.
23226098 interaction between STAT3 and HO-1 abrogates STAT3 activation, and in this way, HO-1 induction represses AR activity, affecting PCa cells tumorigenicity.
23221979 STAT3 and EIF2AK2 interact and have roles in controlling fatty acid-induced autophagy
23220625 REVIEW: potential/putative role of STAT3 signaling in nasopharyngeal carcinoma pathogenesis and anti-STAT3 targeting as a therapeutic and possible prevention strategy for NPC
23207521 We were able to confirm the presence of STAT3 mutations in large granular lymphocytic leukemia in a high frequency of 72.7%.
23193966 rs1053023, more so than the STAT3 rs1053004 or JAK2 rs2230724 polymorphisms, is associated with RSM risk.
23192865 The functions of TSLP in asthmatic airway remodelling were performed through STAT3 signalling pathway.
23185365 ubiquitin ligase TRAF6 negatively regulates the JAK-STAT signaling pathway by binding to STAT3 and mediating its ubiquitination
23178493 this is the first study showing the crucial role of NF-kappaB/Stat3 nuclear association in IR-induced ICAM-1 regulation and implies that targeting NF-kappaB/Stat3 interaction may have future therapeutic significance in glioma treatment.
23172665 STAT3 regulates the transcription and expression of Oct-1 by directly targeting its promoter.
23166591 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
23166328 The dynamic genome-wide transcriptional responses were nearly identical at early time points following stimulation (when STAT3 is active in response to both IL-6 and IL-10) but divergent at later times (when STAT3 is active only in response to IL-10).
23166300 TCPTP deficiency in human breast cancer cell lines enhances Src family PTKs and STAT3 signaling.
23161342 HBx activates the Twist promoter by activating STAT3 and promotes epithelium-mesenchymal transition occurrence in liver cells.
23158658 Leptin/STAT3 signaling is a novel pathway for the up-regulation of hTERT expression in breast cancer cells.
23149124 STAT3 is not crucial for the control of basal cell proliferation and survival of lung carcinoma cells but modulates susceptibility to DNA damaging chemotherapeutics by regulation of intrinsic pro-survival pathways.
23134344 These results suggest a critical association between altered expression of STAT-3 and STAT-5 with SOCS-1 and indicate its potential role as a negative regulator independent of JAK-STAT pathway in tumorigenic transformation of prostate tissue.
23127549 Our results suggest for the first time that the STAT3 gene might be involved in PsA but not in Behcet's disease predisposition.
23125416 CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive Ga14/16 signaling and IL-6 release.
23124042 GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric cancer cells to radiation.
23111066 Data indicate that knockdown of HDAC8 resulted in the increased expression of SOCS1 and SOCS3, and overexpression of SOCS1 and SOCS3 significantly inhibited cell growth and suppressed JAK2/STAT signaling.
23108375 Using two renal cellular models&SOCS-3 siRNA knockdown,we studied SOCS-3 effects on oncostatin M-induced STAT activation, differentiation and proliferation.SOCS-3 knockdown resulted in enhanced pSTAT1/3 phosphorylation & epithelial diff'n.
23108098 these results indicate that thrombin might activate c-Src to induce JAK2 activation, which in turn, causes STAT3 activation, and finally induces CCN2 expression in human lung fibroblasts.
23097472 these findings revealed a novel functional link between C/EBPbeta and STAT3 that is a critical regulator of endometrial differentiation in women.
23094050 APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.
23089473 STAT3 is critical for cancer stem cells survival.
23084476 Report mechanism of autophagy control that involves STAT3 and PKR as interacting partners.
23083634 High STAT3 phosphorylation is associated with reduced anti-EGFR-based therapy in patients with metastatic colorectal cancer
23079657 show that STAT3 directly upregulates the epithelial expression of the inflammatory mediator Toll-like receptor (TLR)2 in gastric tumors
23074171 Results suggested that STAT3-RANTES autocrine signaling is essential for maintenance of drug resistance and inhibition of programmed cell death.
23068100 These results provide evidence that activated STAT-1 and STAT-3 regulate VEGF expression indirectly, by modulating HIF-1alpha activity.
23066027 STAT3 activation is directly integrated with the receptor tyrosine kinase-GIV-G protein signaling axis.
23065274 STAT3 rs1053023 was positively associated with idiopathic recurrent miscarriage in both Bahraini and Tunisian women.
23063454 STAT3 polymorphism can be a predictive marker for treatment with IFN-alpha for patients with metastatic renal cell carcinoma.
23056515 a previously unknown link between Wnt3a-mediated activation of STAT3 and cell survival
23043161 The results implicated excessive STAT3 signaling in the development of skeletal muscle insulin resistance in type 2 diabetes.
23042197 postseptic CD4 T cells are primed toward IL-17 production via increased STAT3-mediated gene transcription, which may contribute to the immunopathology of a secondary viral infection.
23030674 Uropathogenic Escherichia coli strain-infection decreases STAT3 phosphorylation in 5637 cells.
23018838 Inactivation of EGFR by the monoclonal antibody Cetuximab and RNA interference against STAT3 or DeltaNp63alpha.
23018644 Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP.
23007731 GABA may inhibit the growth of cholangiocarcinoma QBC939 cells through the GABAB receptor, and the anti-cancer effects may be partly mediated via the JAK/STAT3 pathway.
22987449 JAK2 and STAT3 activation is not essential for CCL3, CCL5 or CCL8 induced chemotaxis.
22984561 apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma
22967991 CSE1L- and inhibitor of DNA binding-3 (ID3)-overexpression was associated with the diagnosis of BL and signal transduction and transcription-3 (STAT3) with DLBCL (P<0.001 for all markers). All three markers were associated with patient outcome in DLBCL
22967106 Consequently, p27 of hepatitis delta virus activated the signal transducer and activator of transcription-3 (STAT-3) and the nuclear factor kappa B (NF-kappaB) via the oxidative stress pathway.
22959364 STAT3 and STAT5 may function through the IL-6 and IL-2 pathways to play a role in the imbalance of Th17/Treg in NP.
22941903 The results of this study suggested that the STAT3-mediated astrogliosis protects myelin development in neonatal brain injury
22938476 The expression levels of STAT3, P-STAT3, and VEGF-C were higher in small cell lung cancer than in normal tissue; STAT3 and VEGF-C play important roles in the development of small cell lung cancers
22932892 Physiological concentrations of hydrogen peroxide activate hepcidin transcription through signal transducer and activator of transcription 3 protein.
22927445 the intracellular interaction of IL-32alpha with PKCepsilon and STAT3 promotes STAT3 binding to the IL-6 promoter by enforcing STAT3 phosphorylation, which results in increased production of IL-6.
22911368 STAT3 is involved in sperm functions.
22905257 Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes, showing that STAT3 signaling is redox-sensitive
22904633 After the cancer cells were incubated with the synthesized PLGA nanocomplexes, PLGA-PEI-TAX-S3SI suppressed Stat3 expression and induced more cellular apoptosis in A549 and A549/T12 cells compared with PLGA-PEI-TAX.
22895078 MLS-2438 inhibits viability and induces apoptosis of human melanoma cells associated with inhibition of STAT3 and Akt signaling.
22891351 In the context of thyroid cancer, STAT3 is paradoxically a negative regulator of tumor growth.
22859607 STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia.
22844427 vSOCS inhibits IFN-alpha-induced Stat1/Stat3 signaling.
22843679 Migfilin positively modulates the expression and activity of epidermal growth factor receptor, and Migfilin-mediated migration and invasion depend on epidermal growth factor receptor-induced PLC-gamma and STAT3-signaling pathways.
22842992 Targeting STAT3 using a specific inhibitor may be a useful cancer treatment approach, with the potential for a broad clinical impact.
22814105 Together these results suggest that the inhibitory effect of OSM on TGF-beta1-induced CTGF mRNA expression is mainly driven by STAT3, thereby providing a signaling mechanism whereby OSM may contribute to tubulointerstitial protection.
22808266 IL-22 up-regulates K17 expression in keratinocytes in a dose-dependent manner through STAT3- and ERK1/2-dependent mechanisms.
22802294 Overview of the role of STAT3 in regulating cellular responses that may contribute to or inhibit pro-fibrotic processes in idiopathic pulmonary fibrosis. [Review Article]
22799634 results highlight STAT3beta as a significant transcriptional regulator in its own right, with additional actions to cross-regulate STAT3alpha phosphorylation and nuclear retention after cytokine stimulation
22791907 Stat3 forms a multiprotein complex with Rac1 and PKC in an hypoxia-reoxygenation-dependent manner.
22789685 analysis of the positive link between STAT3 activation and Th17 cell infiltration to the lesional skin in vitiligo vulgaris
22786753 H. pylori induced inflammation up-regulate Hath1 expression via interleukin-8/STAT3 phosphorylation while suppressing Hes1, which provides a novel molecular connection between a H. pylori infection and intestinal metaplasia.
22777388 HIV-1 interaction with dendritic cells modulated their functionality, causing them to trigger the activation of the P38MAPK/STAT3 pathway in T cells.
22761423 STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
22760497 results provide evidence that CD24 regulates STAT3 and FAK activity and suggest an important role of Src in this process.
22753872 STAT3 is aberrantly hypomethylated and overexpressed in hematopoietic stem cells of myelodysplastic syndromes patients.
22753649 The findings suggest that variants in the STAT3 gene may contribute differentially to susceptibility to rheumatoid arthritis in seropositive and in seronegative patients.
22751495 Recurrent bacterial skin and respiratory tract infections were consistently observed in STAT-3 deficient patients.
22751114 Targeting Stat3 or Smad7 for knockdown results in resensitization of TGF-beta's cytostatic regulation in vivo.
22750444 previously unknown STAT3-USP7-P53 molecular network controlling colon cancer development
22745305 Persistent activated STAT3 colocalizes with elevated expression of S1PR1, a G-protein-coupled receptor for sphingosine-1-phosphate (S1P), in the tumor cells of the activated B cell-like subtype of diffuse large B-cell lymphoma.
22743617 STAT3 was activated and that the activation could be blocked by an IL-6-neutralizing antibody.
22736176 Modulation of STAT-3 in CD4+ T cells affects the differentiation of Th17 cells and Treg cells in patients with rheumatoid arthritis.
22735740 The altered JAK2 induced STATs response in human failing cardiomyocytes may be of relevance for the progression of cardiac dysfunction in heart failure.
22723956 endogenous STAT3 expression is a determinant of intrinsic taxane resistance in lung cancer.
22712053 Data show that LIF through STAT3 negatively regulates Th2 differentiation.
22711165 STAT3 dimerization at the receptor are essential for the dynamics of early pathway activation.
22709411 Reduction of miR-21 repressed human telomerase reverse transcriptase expression in a STAT3-dependent fashion, subsequently inhibiting glioblastoma cell growth.
22693070 STAT1 expression is upregulated by nuclear EGFR and HER2, and that STAT3 synergizes with the three receptors to further enhance STAT1 expression.
22656398 Interleukin-27 and interleukin-12 augment activation of distinct cord blood natural killer cells responses via STAT3 pathways.
22644781 STAT3 was inactivated in most LMS cases.
22634616 STAT3 and BLIMP-1 constitute an incoherent feed-forward loop downstream of IL-21 that can coordinate microRNA with mRNA expression during plasma cell differentiation.
22630347 beta-catenin pathway regulates miR-21 expression in umbilical vein endothelial cells and glioma cells. This is STAT3 dependent.
22624714 Demonstrate that S1PR1-STAT3 signalling enables myeloid cells to intravasate, prime the distant organ microenvironment and mediate sustained proliferation and survival of their own and other stromal cells at future metastatic sites.
22614117 Interleukin 11 regulates endometrial cancer cell adhesion and migration processes via phosphorylation of STAT3
22613986 present study demonstrates that Ang II induces angiogenic factors production partly via AT1/ JAK2/STAT3/SOCS3 signaling pathway in MHCC97H cells
22591296 The SH2 dimerization and activation domain of STAT3 is frequently mutated in patients with large granular lymphocytic leukemia; these findings suggest that aberrant STAT3 signaling underlies the pathogenesis of this disease.
22581828 results suggest that Notch1/STAT3/Twist signaling axis is involved in progression of human gastric cancer and modulation of this cascade has potential for the targeted combination therapy
22581330 STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway.
22575502 these results demonstrate that in results demonstrate that in human endothelial cells resistin up-regulates SOCS3 expression and activates STAT3 transcription factor.
22574813 Dynamin II function is required for EGF-mediated Stat3 activation but not Erk1/2 phosphorylation
22562532 STAT3 signaling pathway may correlate with epigenetic aberrance during gastrocarcinogenesis
22547799 Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.
22547065 Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.
22535619 High phospho-STAT3 expression is associated with mucosal relapse in ulcerative colitis.
22532634 The authors have identified IL-6-mediated STAT-3 signalling in CD4 T cells during the earliest clinical phase of rheumatoid arthritis.
22532166 findings show that Stat3-induced stem cell expansion plays a critical role in the unique clinical progression of invasive bladder cancer through the CIS pathway
22528488 Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling.
22521547 present study suggests that IL-6 inhibits senescence but promotes the survival and proliferation of tumor cells exposed to DNA damage through the activation of the JAK1-STAT3 signaling pathway
22509288 model for the differential activation of STAT3 or STAT6 by two distinct regions of the viral Tip protein
22506067 Abrogation of the IL-10/STAT3 pathway restored LPS-induced TNF-alpha production in the presence of suppressive patient plasma.
22504904 The anticancer effects of celecoxib on nasopharyngeal carcinoma cell lines results from inducing apoptosis and cell cycle arrest, which may be partly mediated through the STAT3 pathway.
22504301 PLD acts as an important regulator in Bcl-2 expression by activating STAT3 involving the phosphorylation of Ser727 through the PLA(2)/G(i)/ERK1/2, RhoA/ROCK/p38 MAPK, and Rac1/p38 MAPK pathways.
22492280 GRIM-19 expression is closely correlated with histological grading and p-STAT3 in hepatocellular carcinoma
22491065 IL-6 increased IL-21 production by human CD4(+) T cells driving STAT3-dependent plasma cell differentiation.
22488042 Stage IV melanoma patients without CNS metastasis treated with p-STAT3 inhibitors in efficacy studies should be stratified based on tumor expression of p-STAT3.
22484976 Expression of pSTAT3 correlates with Her-2 status and CAIX expression and is associated with tumor progression and worse outcome in esophageal cancer
22480875 Pretreatment of tumor cells with STAT3 specific inhibitors or knocking down of STAT3 by SiRNA makes the tumor cell more susceptible to apoptosis and dendritic cell mediated inhibition of both CD24 and HER-2/neu
22467101 STAT3 might be correlated with tumor differentiation, and its elevated expression may be an adverse prognostic indicator for patients with NSCLC.
22450744 Results show that accumulation of pSTAT3-Tyr705 promotes EGFR L858R mutant cell death, thereby confirming the existence of a STAT3-dependent pro-apoptotic pathway in these lung cancer cells.
22438130 Chrysanthemum indicum extract suppressed constitutive STAT3 activation in parallel with the inhibition of constitutive JAK1 and JAK2 activation in human prostate carcinoma cells.
22418922 Identify STAT3 as a key molecule for the proliferative response of SMC and neointima formation.
22418867 Ser727 phosphorylation on STAT3 is not necessarily a secondary event after Tyr705 phosphorylation and suggest that it has a role in the regulation of cell survival activity and nuclear translocation of STAT3 in melanocytic cells.
22417709 Activator of transcription 3 (STAT3) pathway is implicated in the production of various cytokines in patients with primary Sjogren's syndrome.
22417306 RNAi to diminish expression of ErbB receptors and AP-1 proteins strongly suggested that STAT3 established a balance that maintains the appropriate set of AP-1 proteins and participates in a complex network for regulating keratinocyte differentiation.
22407921 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
22401280 EGF-mediated CYR61 upregulation in HES cells involves STAT3 and is counter-regulated by the EGFR/MAPK/ERK pathway.
22396544 Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3)-dependent up-regulation of matrix metalloproteinase 2
22394684 PTPMeg2 is an important phosphatase for the dephosphorylation of STAT3.
22394639 the expression of phosphorylated STAT3 (pSTAT3) in non-small cell lung cancer
22381273 Both STATs 1 and 3 were highly expressed in cerebral arteriovenous malformation, mainly in the endothelium of AVM blood vessels and perivascular infiltrating inflammatory cells within the nidus.
22378781 Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA
22376160 the GG genotype might confer increased resistance to standard chemotherapy in acute myeloid leukemia (AML) in the Chinese population
22374428 The role of Phospho- STAT3 as an important independent prognostic marker in node-positive breast cancer patients.
22369852 Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo
22364921 Data suggest that TSLP might downregulate NME1 expression via STAT3 signaling pathway, affecting TIMP1 expression in influencing trophoblast invasion.
22350508 The STAT3 silencing by siRNA inhibited the proliferation of AGS human gastric cancer cells through G1 cell cycle arrest, decreased levels of immune-suppressive cytokines, and increased levels of immune-activating cytokines.
22349830 the possible role of MMP-2/alpha5beta1 interaction in the regulation of alpha5beta1-mediated IL-6/Stat3 signaling activation
22342309 Targeting both Sp1 and Stat3 is a potential preventive and therapeutic strategy for pancreatic cancer.
22340714 STAT3 plays a key role not only in cardiac protection but also in the control of cardiac-related inflammation. Review.
22336225 Prostacyclin receptor-dependent inhibition of human erythroleukemia cell differentiation is STAT3-dependent
22331430 A subset of genes uniquely regulated by STAT3 in response to leptin was identified in cells exposed to Entamoeba histolytica.
22330135 IKBKE is a direct target of STAT3 and is induced by tobacco carcinogens through STAT3 pathway.
22328572 The STAT3 pathway plays a key role in mediating CSC properties in ATC-CD133+ cells.
22322297 This data suggest that STAT3 activation regulates several pathways in human lung fibroblasts associated with normal wound healing, whereas aberrant STAT3 signaling plays a critical role in idiopathic pulmonary fibrosis pathogenesis.
22319590 JAK2/STAT3 signaling operates independent of known driver mutations in non-small cell lung carcinoma and plays critical roles in tumor cell behavior that may not be effectively inhibited by drugs that selectively target these driver mutations.
22317895 Thymic stromal lymphopoietin may upregulate c-Myc expression through activation of STAT3 pathway, thereby inducing trophoblast proliferation.
22312430 a model of CagA-directed REG3gamma expression in gastric epithelial cells via activation of the IL-11/gp130/STAT3 pathway
22311708 SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors.
22303479 Piwil2 plays a role in anti-apoptosis in tumor cells possessing P53 as a positive regulator of STAT3 signaling pathway.
22302289 The specific knockdown of Stat3 by RNA interference strongly inhibited the motile and invasion activity of tumour cells.
22301404 Increased Phospho STAT3 is associated with progression of esophageal squamous cell carcinoma.
22289525 Increased STAT3 and decreased cyclin D1 protein levels may contribute to the recurrence of astrocytic tumours.
22279540 Findings show that multiple signaling events impinge on Stat3 and that 14-3-3zeta serves as an essential coordinator for different pathways to regulate Stat3 activation and function in multiple myeloma cells.
22273698 Data show that IL-6 treatment increased expression of phosphorylation of signal transducer and activator of transcription 3 (STAT3) and Pim-1 kinase.
22269120 Data indicate that the rs744166 STAT3 variant in homozygous form showed a significantly elevated odds ratio of 1.483 for the development of ulcerative colitis (UC) but conferred no significant risk of Crohn's disease (CD).
22260073 The high expression level of Stat3 and Cyclin D1 protein in laryngeal squamous cell carcinoma was correlated with the clinical stage, tumor differentiation and lymph node metastases.
22252296 these results suggest a previously unknown Stat3-Skp2 molecular network controlling cervical carcinoma development.
22238455 STAT3-mediated IL-21 signaling can supplement partial t-cell receptor signaling caused by the lack of CD8 association.
22233524 phospho-Ser727 determines the duration of STAT3 activity largely through TC45.
22221142 peripheral blood lymphocytes (PBLs) of ovarian cancer patients showed lower JAK3, CD3-zeta molecules expression levels, as well as lower STAT3 and CD3-zeta phosphorylation levels than cells of control.
22218594 Pien Tze Huang promotes cancer cell apoptosis and inhibition of proliferation via suppression of STAT3 pathway in colorectal neoplasms.
22211709 Persistent activation of STAT3 is a unifying hallmark of a majority of solid malignancies--[REVIEW}
22208386 Our results suggest that p-STAT3 is an important factor during carcinogenesis and metastasis of lung carcinoma.
22206672 Taken together our studies further reveal that STAT3 plays a key role in SPARC induced G2/M arrest in medulloblastoma cells.
22205702 the roles of STAT3 in colorectal cancer epithelial-mesenchymal transition and in STAT3-induced down-regulation of E-cadherin
22205606 STAT3 genetic polymorphism is associated with the susceptibility to BD.
22203730 Data suggest that nitidine chloride is a promising anticancer drug candidate as a potent STAT3 signaling inhibitor.
22197944 STAT3 ''A'' risk allele is associated with increased cellular STAT3 activation and upregulation of pathways that promote recruitment of CXCR2+ neutrophils to the gut.
22194600 Heparanase enhances the phosphorylation of STAT3 and STAT5b but not STAT5a in head and neck cancers.
22194466 tumor cell-derived IL-6 induced gp130 and IL-6R-dependent activation of STAT3, leading to reduced caspase-3 activation and apoptosis.
22190485 STAT3 activation is critical for Varicella-zoster virus replication via a survivin-dependent mechanism.
22189341 TGF-beta1, IFN-gamma, IL-6, and IL-22 induce podoplanin-expression in keratinocytes via STAT3 pathway.
22180308 Data show that ectopic expression of STAT3 abolished the apoptotic effect of dovitinib, indicating that STAT3 is indispensable in mediating the effect of dovitinib in hepatocellular carcinoma (HCC).
22174695 Our findings establish a new role for the FGFR4-G388R polymorphism in pituitary oncogenesis, providing a rationale for targeting Src and STAT3 in the personalized treatment of associated disorders.
22171994 Using knockdown of AKT & STAT3, studied the effects of IL-17/AKT signaling in HCC, resulting in IL-6 production, which in turn activated JAK2/STAT3 signaling and subsequently up-regulated its downstream targets IL-8, MMP2, and VEGF.
22168497 skeletal myoblasts undergo apoptosis under oxidant stress in a time-dependent manner and preconditioning of skeletal myoblasts significantly prevented their apoptosis via IL-11/STAT3 signaling.
22154363 nuclear pSTAT3 might play a role as a tumor suppressor in high-grade salivary gland carcinomas
22147524 Our results indicate that turmeric can effectively block the proliferation of tumor cells through the suppression of NF-kappaB and STAT3 pathways.
22140473 Activated Stat3 may regulate the migration of breast cancer cells through the regulation of ATX.
22126101 STAT3 and STAT5 gene SNPs may be prognostic of leukemia.
22123322 Acyl derivatives of boswellic acids are inhibitors of NF-kappaB and STATs
22120672 Data show that inhibitors of Stat3, IGF-IR and Rho GTPase were the most promising therapeutic agents for ovarian cancer.
22118528 These data point to a specific role for STAT3 in human central memory T cell formation and in control of certain chronic viruses.
22110249 A novel dendritic cell(DC) progenitor regulatory pathway in which PGE(2) signaling through EP1/EP3 receptors regulates Flt3 expression and downstream STAT3 activation and survivin expression, required for optimal progenitor survival and differentiation.
22108192 Increased activity of Stat3 and overexpression of PLK1 promote survival and proliferation of esophageal squamous cell carcinoma cells in culture and in mice.
22105366 STAT3 was required for proper induction of IL6 by NF-kappaB
22104727 Stat3 and its target genes were overactivated and/or overexpressed in drug resistant cells
22104307 cell-cell interactions of M2 macrophage/microglial cells with lymphoma cells induced Stat3 activation may provide novel insights into PCNSL pathogenesis
22104200 Constitutive activation of signal transducers and activators of transcription 3 correlates with better prognosis, cell proliferation and hypoxia-inducible factor-1alpha in human gastric cancer.
22098470 Enhanced growth inhibition in hepatoma cells treated with both NSC 74859 and cetuximab suggests that cetuximab resistance is probably mediated via STAT3.
22095154 antiproliferative effect of SOCS-1 was attributable not only to the inhibition of STAT3 but also to that of p38 MAPK activity
22095036 This study supports the association between STAT3 and an increase in multiple sclerosis risk.
22093834 the expression of miR-125b is regulated by STAT3 at the level of transcription. STAT3 binds to the promoter region of miR-125b in vitro and serves as a transactivator.
22084247 a new biological activity for CUEDC2 as the regulator of JAK1/STAT3 signaling and the mechanism by which SOCS3 has been linked to suppression of the JAK/STAT pathway
22082308 pSTAT3 was abnormally expressed in pancreatic adenocarcinoma & related to tumor size, TNM staging & lymphatic metastasis. It may promote tumor angiogenesis via upregulating VEGF & enhance lymphatic metastasis via VEGF-C.
22078209 A 24h exposure of B lymphocytes with NAC is sufficient to show strong inhibition of STAT3 phosphorylation.
22074823 The effects of STAT3 inhibition in colon cancer stem-like cells were examined.
22069317 Elp2 and STAT-3 mediate, at least in part, the stimulation of Hsp70 expression by 4PBA.
22050790 These findings illustrated the biological significance of JAK2/STAT3 signalling in colorectal cancer cell apoptosis.
22046235 STAT3 may exert its oncogenic effect by up-regulating transcription of genes involved in promoting growth and proliferation, but also by down-regulating expression of negative regulators of the same cellular processes, such as Necdin.
22030463 studied the effect of decreased STAT3 signaling on the B-cell compartment in hyper-IGE syndrome with heterozygous STAT3 mutations
22021169 Phosphorylated Stat3 is associated with neoplastic transformation in patients with colitis.
22006329 STAT3 alternative splicing modulation yields an antitumorigenic potential.
22004076 The overall results point towards a novel ability of HDM2 in regulating HIF-1alpha and p-STAT3 levels even in normoxic conditions that eventually lead to an up-regulation of VEGF expression.
21997191 a novel pathway in the melanocyte lineage, linking FGF2-STAT3 signaling to increased PAX3 transcription.
21994466 IL-6- and TNFalpha-induced TNFR2 expression in colon cancer cells is mediated primarily by STAT3 and provide evidence that TNFR2 may contribute to the tumor-promoting roles of STAT3.
21991388 STAT3 plays an important role in regulation of tumor growth, invasion, and angiogenesis, which could be act by reducing MMP-7 expression in pancreatic cancer cells.
21985363 STAT3 and NF-kappaB pathways co-operate in IgA production, with soluble CD40L rapidly activating the NF-kappaB pathway, probably rendering STAT3 probably more reactive to IL-10 signalling.
21977994 Studies indicate that in Th17 cells, activated STAT3 by IL-6 positively regulates H3K4me3 deposition in the Il17 locus.
21957129 HDAC1 and HDAC2 differentially modulate STAT activity in response to IFNalpha2: while they are required for the induction of ISGF3-responsive genes, they impair the transcription of STAT3-dependent genes.
21954831 Our results demonstrate that melatonin receptor/Galpha(16) coupling is capable of triggering the production of cytokines including IL-6, and this autocrine loop may account for the subsequent STAT3 phosphorylation at Tyr(705)
21953450 NFI-X3 and STAT3 control the migration of differentiating astrocytes as well as migration and invasion of glioma cells via regulating YKL-40 expression.
21948749 polymorphisms in the STAT3 gene may have a protective role in the development of non-small cell lung cancer (NSCLC), particular of stage III/IV NSCLC
21948258 both rs6503691 T allele and CT/TT genotypes, but not rs4796793 C/G in STAT3, are associated with a significantly increased risk of dilated cardiomyopathy
21938013 data point toward a pivotal role for an autocrine positive feedback loop involving IL-21 and consequent persistent STAT3 activation in the pathogenesis of Sezary syndrome
21937440 Both STAT3 and NFkappaB are required for the cytokine-induced expression of fascin in cancer cells.
21926348 CD5 costimulation induces more Th17 cells that produce higher amounts of IL-17, which is preceded by prolonged activation of signal transducer and activator of transcription 3 (STAT3).
21913828 Glioblastoma-derived IL-6 is responsible for the observed suppression of Langerhans cell differentiation from CD34(+) precursors but appears to exert this effect in a STAT3 and Raf-1 independent fashion
21900397 ALDH(+)/CD133(+) cells expressed higher levels of the active phosphorylated form of STAT3 than either ALDH(-)/CD133(-) or unfractionated colon cancer cells.
21897114 STAT3 activities of human papillary thyroid cancer tissues are significantly lower than those of surrounding normal thyroid tissues.
21892329 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
21890685 Dehydroepiandrosterone reverses pulmonary hypertension in part by inhibiting the Src/STAT3 pathway.
21886773 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
21876460 Deregulated expression of pSTAT3 and SOCS3 might possess potential roles in the development and progression of human cutaneous melanoma.
21875334 The M4 adenovirus could specifically deplete constitutive and inducible STAT3 and phosphorylated STAT3 proteins in ovarian cancer cells.
21871555 This is the first evidence that PPAR-gamma activation can counteract STAT-3-dependent escape pathways to IFN-beta-induced growth inhibition through cell cycle perturbation and increased autophagic death in pancreatic cancer cells.
21866460 Epigallocatechin-3-gallate reduces expression of VEGF in gastric cancer cells through the inhibition of Stat3 activity.
21835168 These results indicate that STAT3 is essential for VEGF-A-induced lymphatic endothelial cell (LEC) migration and tube formation and that STAT3 regulates LEC functions.
21835143 results showed a cross-talk between cyclic-AMP and JAK/STAT pathways in liver tumors and they reinforce the role of STAT3 activation in liver tumorigenesis
21818116 data demonstrate that constitutive activation of STAT3 in Sezary syndrome is not due to the loss of SHP-1, but is mediated by constitutive aberrant activation of JAK family members
21806788 STAT3 is more frequently expressed in non-GCB DLBCL than that in GCB subtype, and its strong nuclear expression is correlated with poor OS in DLBCL.
21796151 The data suggested that IL-17A can upregulate keratin-17 expression in keratinocytes in a dose-dependent manner through STAT1- and STAT3-dependent mechanisms.
21792878 reduced IL-10-mediated phosphorylation of STAT3 in hyper-IgE syndrome patients with mutations in the SH2 domain of STAT3
21788516 Cells transformed by the p110alpha-H1047R mutant of PI3K show increased tyrosine phosphorylation of Stat3.
21782857 PLTP regulates STAT3 and NFkappaB in differentiated THP1 cells and human monocyte-derived macrophages.
21779366 Interplay between SIN3A and STAT3 mediates chromatin conformational changes and GFAP expression during cellular differentiation.(
21750002 Glucocorticoids enhance Th17/Th1 imbalance and signal transducer and activator of transcription 3 expression in systemic lupus erythematosus patients.
21749449 JAK2V617F allele burden was higher in polycythemia vera (PV) and primary myelofibrosis (PMF) patients compared with low allele burden in essential thrombocythemia (ET) and early PMF; higher phosphorylation of STAT5 and STAT3 in JAK2V617F positive group
21747171 pancreatic Stat3 has a role in ER-mediated suppression of lipid synthesis
21733558 Constitutively activated STAT3 induces vascular endothelial growth factor production by chronic lymphocytic leukemia cells and chronic lymphocytic leukemia cells derive a survival advantage from endothelial cells via cell-to-cell contact.
21731057 STAT3 is a modifier gene of cystic fibrosis disease.
21726833 CD24 was found to be a functional liver tumor-initiating cells (T-IC) marker that drives T-IC genesis through STAT3-mediated NANOG regulation.
21726118 immunohistochemical investigation of variables involved in expression of STAT3 (alongside Bak and Bcl-xL) in endometrioid adenocarcinoma tissue: STAT3 is abundantly expressed in nuclei in some patients; expression in ERalpha +/- tissues
21720710 Significant increases in the phosphorylation levels of transcriptional regulation of STAT3-downstream target molecules were observed in colorectal adenoma tissue.
21715323 a novel protective mechanism mediated by mitochondrial STAT3 that is independent of its canonical activity as a nuclear transcription factor.
21711111 CK2 inhibitors enhance the radiosensitivity of human non-small cell lung cancer cells through inhibition of stat3 activation
21701559 We propose that nuclear CD44/acetylated-STAT3 performs an unexpected tumour-progressing function by enhancing cell outgrowth into structures where cells with properties of cancer stem cells can be generated from differentiated somatic cells.
21690253 12% of inflammatory hepatocellular adenoma subsets lacking IL6ST mutations harbor somatic signal transducer and activator of transcription 3 (STAT3) mutations (6/49)
21689689 TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with Hsp90beta and consequently regulates transcription of Nanog in embryonic stem cells.
21689417 study demonstrates that the Src/Stat3 and C/EBP signaling pathways positively regulate the expression of the Jab1 oncogene; results show that Stat3 and LAP2 (C/EBP-beta2) are the two major transcription factors that contribute to Jab1 overexpression that leads to increased proliferation of breast cancer cells
21685938 novel Nanog/Stat-3 signaling pathway-specific mechanism involved in miR-21 production is significant for the formation of future intervention strategies in the treatment of HA/CD44-activated HNSCC
21684758 The prognostic significance of IL-8 expression and its correlation with p-STAT-3 and VEGF implicates this novel signaling pathway in astroglial tumors progression providing new targets for effective immunotherapy.
21684622 In the tumors </=2 cm in diameter, pSTAT3 expression in the central area was higher in preinvasive tumors.
21681336 The inhibited viability of HeLa cells caused by knockdown of c-SRC is associated with the decreased content of p-STAT3 protein.
21677772 Data demonstrate a role of STAT3 in regulation of mdr1 gene expression in myeloid leukemia and suggest that STAT3 may be a promising therapeutic target for overcoming MDR resistance in myeloid leukemia.
21674558 Excessive IL-22 can be found in the hepatocellular carcinoma microenvironment, leading to tumor growth, inhibition of apoptosis, and promotion of metastasis due to STAT3 activation.
21671179 Leptin promotes endometrial cancer growth and invasiveness by activating STAT3 and ERK1/2 signaling pathways.
21668356 STAT3 gene polymorphism (rs4769793) was associated with the susceptibility as well as poor differentiation and parametrial invasion of cervical cancer in Chinese women
21661417 STAT3 and beta-catenin signaling pathway may affect GSK-3beta expression in hepatocellular carcinoma.
21658842 TRP4 can effectively induce the activation of both NF-kappaB and IL6/STAT3 signaling pathways in the pattern similar to that of classical cytokine
21651859 The inhibitory effect of RNA interference on STAT3 expression in liver cancer cell line SMMC7721
21643014 the loss of ARHI expression in the majority of ovarian cancers may result in the upregulation of Stat3 and FAK activity, and thereby contribute to oncogenesis.
21637744 HIV-1-infected/activated monocyte-derived macrophages induces neural progenitor cell astrogliogenesis through the STAT3 pathway.
21633165 Data show that the IL-6/JAK2/Stat3 pathway was preferentially active in CD44+CD24- breast cancer cells compared with other tumor cell types, and inhibition of JAK2 decreased their number and blocked growth of xenografts.
21632716 Intratumoral administration of STAT3 transgene-depleted dendritic cells (DC)markedly inhibits colon carcinoma growth of injected and nontreated remote tumors; STAT3-deficient DCs activate T helper (Th)1 cells and resist cancer-derived inhibitory factors.
21625522 Results indicate STAT3 nuclear import is dependent on the function of importin-beta1
21624746 identified a significant association between STAT3 polymorphism and asthma susceptibility in atopic asthma whereas no such association was observed in the non-atopic asthma group
21619877 The data reveal endosomes as central to the genesis, course and outcome of STAT3 signal transduction and transcription.
21611796 The regulatory effect of the intronic miRNA on eNOS gene expression was associated with miRNA polymorphisms, and mediated through inhibition of STAT3 signaling in ECs.
21607287 Studies indicate that Stat3 signals are pivotal to the proliferation and differentiation of neural stem cells.
21590492 our findings suggest that SOCS3 inactivation by promoter hypermethylation is mutually exclusive to EGFR activation in gliomas and preferentially promotes glioma cell invasion through STAT3 and FAK activation.
21586612 Results show that STAT3 has critical roles throughout the course of PDAC pathogenesis.
21577321 Suggest a potential role for activated pSTAT3 in lymphatic metastases in thyroid cancer.
21575192 constitutive activation of STAT3 is an important factor related to carcinogenesis of human soft tissue tumors and is significantly associated with its clinicopathological parameters
21573184 Evidence is presented for the nuclear presence of a functional heteromeric complex of epidermal growth factor (EGFR), Src and the Signal Transducer and Activator of Transcription (Stat)3 proteins in pancreatic cancer cells.
21562161 inhibition of beta-catenin signaling was dependent on its ability to induce DKK1, in a STAT 3-dependent manner. Inhibition of STAT3 and DKK1 abrogated the ability of IFN-gamma to enhance HIV replication in astrocytes.
21552420 signaling in liver injury, steatosis, inflammation, regeneration, fibrosis, and hepatocarcinogenesis (review)
21549414 Our results suggest that the expression of STAT3 might be an independent prognostic marker for NSCLC patients.
21546410 Activation of the signal transducer and activator of transcription 3 pathway up-regulates estrogen receptor-beta expression in lung adenocarcinoma cells
21539622 CD109 release from the cell surface in human keratinocytes regulates TGF-beta receptor expression, TGF-beta signalling and STAT3 activation.
21520044 LLL12 significantly inhibited STAT3 phosphorylation.
21518725 the level of Stat3 Tyr705 phosphorylation was decreased in B7-H3 knockdown cells .
21502401 STAT3 facilitates NF-kappaB binding to genes that are important for tumor growth while inhibiting its binding to Th-1 immunostimulatory genes in growing tumors, including in tumor-infiltrating immune cells.
21494893 STAT3 plays an integral role in human vascular remodeling and atherosclerosis in a Hyper-IgE syndrome (HIES) cohort patients.
21490132 Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells
21486864 chronic lymphocytic leukemic cells express a functional hepatocyte growth factor receptor (c-MET) and hepatocyte growth factor enhanced the viability of these cells through STAT3 phosphorylation
21486470 Gene silencing of STAT3 leads to cell death by blocking nuclear transfer of STAT3 and STAT3-bound NF-kappaB.
21481791 Constitutively active STAT3 rescued the effects of BMX downregulation, supporting that BMX signals through STAT3 in glioblastoma stem cells (GSCs).
21481788 data describe the involvement of IL-6 transsignaling/Stat3/Socs3 in pancreatic intraepithelial neoplasia progression and pancreatic ductal adenocarcinoma development
21481787 show that Stat3 signaling enforces MMP7 expression in pancreatic ductal adenocarcinoma cells and that MMP7 deletion limits tumor size and metastasis in mice
21479358 STAT3 signaling pathway plays an important role in the angiogenesis of pancreatic cancer.
21470923 Activation of a pro-survival IL-6/JAK2/STAT3 cascade contributes to cholera toxin-induced GFAP expression.
21468569 Intracellular apoptotic signals in HHUA cells are constitutively activated and regulated by STAT3-mediated signals.
21447682 STAT3 enhances the proliferation of limbal keratinocytes through a DeltaNp63-dependent mechanism. Suppression of this pathway inhibits cell proliferation with a concomitant increase of cell differentiation.
21444672 STAT3 mediates resistance to MEK inhibitor through microRNA miR-17
21443800 The novel curcumin analog FLLL32 has biologic activity against osteosarcoma cell lines through inhibition of STAT3 function and expression.
21442485 There was a positive correlation between STAT3 and vimentin expression and a negative correlation between STAT3 and E-cadherin in colon cancer.
21436461 STAT3 phosphorylation is an early event in the healing response to muscle injury after repeated biopsy, probably mediated by the autocrine production of IL-6.
21430300 Single nucleotide polymorphisms in STAT3 is associated with prostate cancer.
21426892 First report of type I hyper-IgE syndrome (HIES) showing a STAT3 gene mutation and MCNS.
21420464 JAK1/STAT3 signaling mediates CK-induced apoptosis in U266 cells and also suggest the chemopreventive potential of CK for treatment of multiple myeloma.
21418908 The JAK2/STAT3 signaling pathway plays an important role in the angiogenesis of non-small cell lung cancer.
21415216 Data show that ALK inhibitor-induced apoptosis is mediated both by BIM upregulation resulting from inhibition of ERK signaling as well as by survivin downregulation resulting from inhibition of STAT3 signaling in EML4-ALK-positive lung cancer cells.
21410405 Finding supports the notion that the combination of inappropriate STAT3 and AP-1 activities drives elevated MMP-1 expression and tissue invasion in colorectal cancer.
21408055 IL-6 induction of STAT3 signaling occurred exclusively in the nuclei of satellite cells in response to muscle-lengthening contractions.
21402692 CYP3A4 is a highly active AA epoxygenase that promotes Stat3-mediated breast cancer cell growth in part through (+/-)-14,15-EET biosynthesis.
21399864 The purpose of this study was to investigate the possible suppressive or stimulatory role of OSM in the ovarian cancer model of SKOV3 cells, as well as the involvement of the ERK1/2, p38 and STAT3 signaling pathways.
21398617 Data show that CD5 expression is associated with NFAT2 activity and mildly STAT3 activity, indicating that CD5 controls IL-10 secretion.
21385902 Data show that PrLZ elevated the phosphorylation of Akt and Stat3 and upregulated Bcl-2 expression.
21385272 Signal transducer and activator of transcription 3 (STAT3) and Suppressor of Cytokine Signaling (SOCS3) balance controls cytotoxicity and IL-10 expression in decidual-like natural killer cell line NK-92.
21382889 inhibition of the inappropriate activation of STAT3/Pim1 axis is a novel, specific, and attractive therapeutic strategy to reverse Pulmonary artery hypertension.
21364020 STAT-3 binds to the NF-kappaB p50/p65 dimers and that the STAT-3/NF-kappaB complexes bind to DNA and activate NF-kappaB-regulated genes
21346774 malignant T cells in cutaneous T-cell lymphoma (CTCL) lesions express IL-17 and that this expression is promoted by the Jak3/Stat3 pathway.
21343371 Data supports activation of a central IL6-STAT3-HIF1A pathway in OCCA.
21339300 ATP-binding membrane cassette transporter A1 and signal transducer and activator of transcription 3 have roles in tristetraprolin-dependent post-transcriptional regulation of inflammatory cytokine mRNA expression by apolipoprotein A-I
21333372 mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer
21325207 Data show that MUC1-C interacts directly with JAK1 and STAT3.
21321954 STAT3 phosphorylation is increased in skeletal muscle following intense exercise.
21316706 activated STAT3 signal may associate with Twist and E-cadherin expression and mediate HCC invasiveness and metastasis.
21311318 STAT3 down-regulation resulted in an increase of Survivin/BIRC5 and BCL-xL mRNA in pancreatic neoplasms.
21310826 STAT3 activation in colorectal cancer is associated with adverse clinical outcome
21310444 Common variation in the STAT3 may influence mtDNA copy number.
21307288 Strong activation of Stat3, such as by interleukin (IL)-6 in inflamed tissue, results in release from regulatory T cell suppression, whereas functional suppression is restored upon concurrent activation of Stat1.
21293887 Interleukin-6 induction of toll-like receptor 4 gene expression via signal transducer and activator of transcription 3(STAT3) is one of the main mechanisms underlying insulin resistance in human skeletal muscle
21288777 The effects of the site of mutation in the STAT3 domains that are associated with autosomal dominant hyper IgE syndrome are reported.
21282107 Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway.
21268011 During dendritic cell differentiation toll-like receptor agonists induce a STAT-3-mediated expression of PD-L1 and favor the development of tolerogenic antigen presenting cells.
21257710 our findings reveal a novel role for STAT3 in NK cell immunosurveillance by modulating the MICA expression in cancer cells.
21245987 CCN2/CTGF is identified as a hepatocellular negative acute phase protein which is down-regulated by IL-6 via the STAT3 pathway through interaction on the DNA binding level
21224490 The CRE-like site located near the SBE may contribute to the formation of a stable complex of STAT3, HIF-1alpha, and p300/CBP, which leads to maximum transcription of the Hp gene.
21216930 Loss of STAT3 activity in lung cancer cells resulted in reduced cell proliferation and apoptosis and combined EGFR and STAT3 loss had additional antitumor effects.
21211286 Siltuximab effectively blocks the IL-6/Stat3 signaling pathway in ovarian cancer.
21209620 Authors believe in order to exclude the association of STAT3 polymorphisms with MS in particular and any other autoimmune disorders in general, we should investigate polymorphisms in more than four regions within the gene.
21183735 Results reveal an elegant mechanism of eNOS regulation by PECAM-1 through signal transducers and activators of transcription 3-mediated transcriptional control of NOSTRIN.
21178271 Mutations of STAT3 and clinical manifestations of hyper IgE syndromes (Review)
21177324 NZB treatment determines an accumulation of CD4+T-bet+, CD4+pSTAT3+ and CD8+T-bet+ T cells in the peripheral blood of natalizumab treated multiple sclerosis patients.
21174186 Inactivation of STAT3 in pancreatic cancer cell lines induces apoptosis but also may promote the expression of anti-apoptotic genes.
21166956 STAT3-mediated leptin receptor signaling pathways may be activated in human colorectal adenomas.
21152001 Chr1q32 and STAT3 are ankylosing spondylitis susceptibility loci.
21148800 Hyperresponsiveness of transgenic glycoprotein (gp)130 mice to lipopolysaccharide involves specific upregulation of IL-6 in a gp130/STAT3- and Toll-like receptor 4/MyD88-dependent manner.
21148399 Activation of the IL-6/STAT3 pathway in transformed Barrett's epithelial cells enables them to resist apoptosis, indicating a possible contribution of the intrinsic inflammatory pathway to carcinogenesis in Barrett's esophagus.
21138684 a negativie correlation between the expressions of STAT3 and WWOX, but no relationship was found between WWOX and c-myc
21131551 butein exerts its antiproliferative and proapoptotic effects through suppression of STAT3 signaling in HCC both in vitro and in vivo
21122157 Findings suggest that Stat3 could potentially be regulated to suppress IL-6 autocrine production in cancer cells to inhibit the progression of cancer and reduce drug resistance.
21115047 all of the phosphorylated STAT3 positive cells were also positive for phosphorylated STAT1, both of which could be inhibited by a JAK2/STAT inhibitor, AG490
21098725 STAT3-dependent IL-22 signaling and effects in keratinocytes are negatively regulated by SIRT1
21098664 Data show that STAT3 binds to the SOCS3 promoter, and S727 is then phosphorylated, followed by the coincident binding of SET9 and dimethylation of K140, and lastly by the binding of LSD1.
21085192 MicroRNA-21 expression in CD4+ T cells is regulated by STAT3 and is pathologically involved in Sezary syndrome.
21072904 Data show that STAT3 can transform into pSTAT3 to promote the survival and inhibit the apoptosis of gastric cancer cells.
21072187 Observational study of gene-disease association. (HuGE Navigator)
21068102 results demonstrate for the first time that genetic polymorphisms in STAT3, TNFRSF1A and 2p15 are associated with ankylosing spondylitis in Han Chinese, suggesting common pathogenic mechanisms for the disease in Chinese and Caucasian European populations.
21068102 Observational study of gene-disease association. (HuGE Navigator)
21058221 Autosomal dominant hyper-IgE syndrome (AD-HIES), characterised by eczema, increased susceptibility to skin and lung infections, elevated IgE and skeletal abnormalities is associated with heterozygous STAT3 mutations.
20978825 Adiponectin inhibits CRP production in HepG(2) cells elicited by IL-6, by downregulating STAT3 phosphorylation.
20977777 Data show that in the presence of HPV16, STAT3 is aberrantly-expressed and constitutively-activated in cervical cancer which increases as the lesion progresses thus indicating its potential role in progression of HPV16-mediated cervical carcinogenesis.
20974051 We validated STAT3 as a bona fide target of BCL3 in a cervical cancer cell line by additional interference RNA and in silico analyses of previously reported lymphoma patients.
20962850 Observational study of gene-disease association. (HuGE Navigator)
20943775 A role was determined for signal transducer and activator of transcription 3 and Janus kinase-2 transduction in alpha4beta2 nicotinic receptor-mediated anti-inflammatory effects.
20942237 Lower expression of SSTR2 and activation of STAT3 in olfactory neuroblastoma cells might contribute to the development of ONB.
20939893 STAT3 and c-Jun could physically interact and bind to the AP-1 site, implicating that the interplay of both transcriptional factors on the AP-1 site is responsible for isoproterenol-stimulated MMP-7 expression in gastric cancer cells.
20930550 Activated STAT3 directly bound to IL6 promoter and increased IL6 mRNA and protein secretion.
20929863 Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.
20888416 STAT3 activation mediates, at least in part, IFN-gamma-induced neurotoxicity and ICAM-1 expression by human astrocytes.
20886065 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20881637 Abundant tyrosine phosphorylation of STAT3 leads to primary resistance to EGFR inhibitors in lung cancer.
20873543 The expression of STAT3 and c-myc may play an important role in the tumorigenesis, metastases and poor prognosis of laryngeal squamous cell carcinoma.
20873541 STAT3 was positively correlated with the neovascularization of nasal polyps, and was also positively correlated with VEGF expression.
20872151 NF-kappaB and STAT3 transcription factors are especially important signaling hubs for integrating signal pathways to orchestrate effective host defense without excessive inflammatory injury.
20860602 Stat3 activation by IL-6 and IL-10 plays an important role in cell-to-cell interaction between tumor cells and macrophages in the ascites of advanced epithelial ovarian cancer (AdEOC).
20830487 Cell-cell contacts induce STAT3 activity in colon carcinoma cells through an autocrine stimulation loop.
20830236 our results support the concept that STAT3 upregulates the protein expression and transcriptional activity of beta-catenin in breast cancer
20826784 Data identified the oncogenic transcription factor STAT3 as a binding partner of nuclear survivin.
20816194 Observational study of gene-disease association. (HuGE Navigator)
20807804 Expression of a redox-insensitive STAT3 in breast carcinoma cells accelerates proliferation while reducing resistance to oxidative stress.
20802378 Observational study of genetic testing. (HuGE Navigator)
20797623 STAT3 is not only a downstream target of IL-6 but, with miR-21, miR-181b-1, PTEN, and CYLD, is part of the positive feedback loop that underlies the epigenetic switch that links inflammation to cancer.
20716621 Observational study of gene-disease association. (HuGE Navigator)
20709283 Our study provides evidence that the up-regulation of STAT-3 in colonic mucosa may be associated with the progression of ulcerative colitis.
20691278 Data demonstrate that eradication of signal transducers and activators of transcription (STAT3) signaling considerably enhances BMP-induced osteogenic differentiation of hMSCs
20686606 Data suggest that constitutively activated Stat3 binds to the ROR1 promoter and activates ROR1 in CLL cells.
20668024 Data show that STAT3alpha may therefore be a common mediator of oncogenic signaling pathways stimulating progression of EC.
20663948 STAT3 was activated in primary mantle cell lymphoma cells either constitutively through a cytokine autocrine loop or in response to B-cell receptor engagement, both processes leading to a survival signal inhibited by bortezomib.
20661303 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
20652679 AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).
20634891 Observational study of gene-disease association. (HuGE Navigator)
20628624 Meta-analysis of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20627814 There was no difference in the distribution of allele and genotype in either JAK2 or STAT3 between ankylosing spondylitis groups and controls.
20627814 Observational study of gene-disease association. (HuGE Navigator)
20585009 Impaired downregulation of gp130-mediated STAT3 activation in subacute infarction promotes cardiac inflammation, adverse remodeling, and heart failure, suggesting a potential causative role of high interleukin-6 serum levels after myocardial infarction.
20568281 HIV-1 activation of STAT1 and STAT3 in human brain microvascular endothelial cells (HBMEC) is associated with induction of promoter activity of the interferon-stimulated response element (ISRE)/interferon-gamma-activated sequence (GAS).
20562100 LLL12, a STAT3 small molecule inhibitor, blocked IL-6-induced STAT3 phosphorylation, resulting in attenuation of the anti-apoptotic activity of IL-6.
20558345 simultaneous expression of HGF/c-met and three trasducers of tyrosine kinase receptors STAT3, PI3K, RHO in both nodular and extranodular tissues were studied by immunohistochemistry in 50 benign thyroid nodules, 25 associated with Hashimoto's thyroiditis
20546860 STAT3 plays crucial roles in osteosarcoma development
20519510 Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes
20516148 These findings indicate that TRIM8 enhances the STAT3-dependent signal pathway by inhibiting the function of PIAS3.
20516069 the cdk5-STAT3 oncogenic pathway plays an important role in the expression of DNA repair genes and that these proteins could be used as predictive markers of tumors that will fail to respond to chemotherapy.
20515335 The proportion of phosphorylated STAT3alpha relative to STAT3alpha was significantly greater in supratentorial PNETs than in medulloblastomas.
20514402 STAT3 is an important target for human GSCs in regulation of glioblastoma stem cells(GSCs) growth, apoptosis, differentiation and tumorigenic potential.
20507639 arecoline induces anoikis of HA22T/VGH cells involving inhibition of STAT3 and increased RhoA/Rock activation
20503287 Observational study of gene-disease association. (HuGE Navigator)
20490331 significantly decreased cell viability and increased apoptosis in human neuroblastoma cell line in association with down-regulation of p-ERK1/2, p-Akt, p-STAT3 survival pathways.
20490271 genetic polymorphism is associate with Hyper-IgE syndrom (case report from Cina)
20484656 Interferon-gamma-induced suppressor of cytokine signaling (SOCS)3 expression leads to inhibition of interleukin (IL)-6-induced STAT3 activation and IL-6-dependent expression of anti-, but not pro-inflammatory, target genes.
20483734 Thymic stromal lymphopoietin induced proinflammatory gene expression in human airway smooth muscle cells involved ERK1/2, p38, and JNK, and STAT3 activation.
20473906 High STAT3 is associated with the maintenance of neurosphere-initiating tumor cells in patients with glioblastomas.
20463292 IL-22, likely via activation of STAT3 and downstream genes (e.g., SOCS3), is able to protect against cell stretch and pulmonary baro-/biotrauma by enhancing epithelial cell resistibility
20463008 These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
20459702 Stat3 pathway is overexpressed in multidrug resistant osteosarcoma cells. CDDO-Me significantly inhibited Stat3 phosphorylation, Stat3 nuclear translocation and induced apoptosis in osteosarcoma.
20456494 Stat3 activation in UV-exposed skin is one of the initial events where DNA damage and ROS are involved.
20447714 HBx-mediated down-regulation of let-7a and up-regulation of STAT3 supports cell proliferation in HBx cells.
20446017 we studied the immunohistochemical expression of STAT-3 proteins in primary central nervous system lymphomas
20438785 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20431064 Src kinase-mediated activation of STAT3 and subsequent angiogenic gene expression mediate the effects of integrin alpha v beta 5 and may be exploited to enhance the paracrine activities of circulating angiogenic cells.
20422486 JAK2/STAT3/vimentin signaling pathway participates in regulating the proliferation and migration of human colon cancer cells.
20406964 Observational study of gene-disease association. (HuGE Navigator)
20399615 Stat3 activation is induced by hydrogen peroxide exposure to the skin in healthy individuals
20388777 amplified FGFR expression engages the STAT3 pathway
20380698 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20371693 High nuclear STAT3 expression levels are not associated with head and neck squamous cell cancers.
20368117 Over-expression of JAK/STAT signal pathway may be an important feature of hepatocellular carcinoma.
20359118 Stat3 and Cyclin D1 were overexpressed in laryngeal neoplasm tissue, and they have a positive relationship.
20356901 the immunosuppressive effects of IL-10-STAT3 on MHC-II antigen presentation may occur via the inhibition of cathepsin S expres
20351189 Treatment of lymphocytic choriomeningitis virus Armstrong-infected Stat3 conditional knockout mice induces neither immune suppression or T cell deletion.
20348091 the phosphorylation status of CagA affects the signal switch between the SHP2/ERK and JAK/STAT3 pathways through gp130, providing a novel mechanism to explain H. pylori signaling.
20331635 IR induces Bcl-X(L) accumulation via STAT3, which then promotes cancer cell invasion and epithelial-mesenchymal transition(EMT)-associated markers.
20331378 Observational study of gene-disease association. (HuGE Navigator)
20237496 Observational study of gene-disease association. (HuGE Navigator)
20232316 VEGF expression in breast cancer cells is mediated by HIF-1 and STAT3 in a miR-20b-dependent manner.
20229017 IL-6/STAT3/TFF3 signaling is involved in human biliary epithelial cell migration and wound healing.
20222910 Observational study of gene-disease association. (HuGE Navigator)
20213502 STAT3 inhibition downregulated the expression of Bcl2 family of anti-apoptotic gene Bcl-xL.
20209132 STAT3 has a role in in vitro transformation triggered by TRK oncogenes
20204302 STAT3 inhibition using si-RNA suppressed VEGF secretion in the SNU-1041 head and neck cancer cell line
20200543 Data show that the STAT3 haplotype conformed by the risk alleles of each polymorphism was significantly associated with both clinical phenotypes of IBD.
20200543 Observational study of gene-disease association. (HuGE Navigator)
20199106 Treatment of a glioblastoma stem cell line culture with a STAT3 phosphorylation inhibitor (WP1193) or 10% FBS (fetal bovine serum) both led to a decrease in expression of the stem cell marker CD133, but differed in phenotype changes.
20197401 Targeting STAT3 may enhance treatment efficacy against pancreatic cancer.
20196786 5-aza-dc can induce SHP1 expression and inhibit JAK2/STAT3/STAT5 signalling
20167868 Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth
20164027 Expressions of STAT3 show mutual correlations in primary ductal breast cancers, which suggest co-operation among the protein.
20160059 ZIP4 overexpression causes increased IL-6 transcription through CREB, which in turn activates STAT3 and leads to increased cyclin D1 expression
20159255 In 64 patients with hyper-IgE syndrome, we identified 31 different STAT3 mutations, 18 of which were novel.
20159251 p-STAT3 levels are decreased in chronic rhinosinusitis with nasal polyps despite increased levels of IL-6 and sIL-6R and are associated with the absence of an IL-17 response
20159113 STAT3 represents a shared risk locus for multiple sclerosis and Crohn disease.
20159113 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20154216 constitutive phosphorylation of STAT3 on serine 727 residues is a hallmark of CLL and that STAT3 be considered a therapeutic target in this disease.
20149460 data suggest that the novel G342D mutation affects the binding of STAT3 on DNA and the STAT3-dependent expression of retinoid-related orphan receptor gammat mRNA, leading to the hyper-IgE syndrome phenotype.
20149042 constitutive activation of Stat3 signaling pathway may play an important role in the invasion and prognosis of epithelial ovarian carcinoma.
20145033 These findings indicate the existence of the nuclear EGFR/EGFRvIII signaling pathway in GBM and its functional interaction with STAT3 to activate COX-2 gene expression.
20132164 demonstrates that antiphospholipid antibodies limit trophoblast cell migration by downregulating trophoblast IL-6 secretion and STAT3 activity.
20128024 Data suggest that the up-regulation of CR-1 and p-STAT3 may play important roles in gastric carcinogenesis and lymph node metastasis
20124472 A chemical genetics approach reveals STAT3 as a novel neurofibromin/mTOR pathway signaling molecule, define its action and regulation, and establish STAT3 as a tractable target for future NF1-associated cancer therapy studies.
20120862 The mRNA expression levels of EGFR and STAT3 in laryngeal papilloma tissue were significantly higher than that in normal laryngeal tissue. p-STAT3 expression was correlated with recurrence and metastasis.
20113333 lack of spontaneous STAT3 and STAT5 activation and the normal response to TPO is unexpected as MPLW515L leads to constitutive receptor activation and hypersensitivity to TPO in experimental models
20109474 Carrying either the JAK2 or STAT3 IBD risk allele was associated with significantly enhanced susceptibility to DNA damage, as estimated by comet assays
20109474 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20107204 Human placental multipotent mesenchymal stromal cell-conditioned medium activated STAT3 expression in endothelial cells, supporting cell survival. STAT3 activation and SOD2 production protect against oxidative stress-induced endothelial cell damage.
20106947 Stat3 could be the major target for increasing chemosensitivity in patients who develop chemoresistance during chemotherapy.
20072652 Data show that LLL12 inhibited STAT3 phosphorylation, induced apoptosis as indicated by the increases of cleaved caspase-3 and poly (ADP-ribose) polymerase, and also downregulated cyclin D1, Bcl-2, and survivin at both protein and messenger RNA levels.
20072651 Data suggest that INCB16562 is a potent JAK1/2 inhibitor and that mitigation of JAK/STAT signaling by targeting JAK1 and JAK2 will be beneficial in the treatment of myeloma patients, particularly in combination with other agents.
20069389 These results indicate that Stat3 plays a key role in the invasion and apoptosis of human glioma cell line U251.
20068065 Plumbagin inhibits STAT3 activation pathway through the induction of SHP-1 and this may mediate the sensitization of STAT3 overexpressing cancers to chemotherapeutic agents.
20065083 Levels of STAT3 mRNA correlate with polymorphic differences in genes encoding interferon alpha signal transduction components and might account for different patient responses in chronic myeloid leukemia.
20065083 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20059466 Observational study of gene-disease association. (HuGE Navigator)
20053772 These findings indicate that cancer-initiating cells contribute to the immune evasion of glioblastoma multiforme and that blockade of the STAT3 pathway has therapeutic potential.
20053726 Expression of a constitutively activated STAT3 mutant or myristoylated AKT partially blocked the effects of sunitinib in these tumor cells.
20052595 The STAT3 has an important role in the occurrence and development of human meningioma by regulating VEGF expression.
20048285 STAT3-activating cytokines such as IL-21 thus underpin Ag-specific humoral immune responses and provide a mechanism for the functional antibody deficit in STAT3-deficient patients.
20043094 Specific siRNA targeting STAT3 gene is able to enhance the radiosensitivity in Hep-2 cells by regulating expression of Bcl-2, VEGF and p53 proteins.
20038814 Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade.
20032975 In human glioma, expression of C/EBPbeta and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome
20032313 these findings uncover a novel mechanism whereby IL-10-activated STAT3 modulates IL-1ra transcription in LPS-treated phagocytes by making IL-1ra promoter accessible to readily available nuclear NF-kappaB.
20032196 study indicates that IL-6 induces a novel STAT3-APE1 complex, whose interaction is required for stable chromatin association in the IL-6-induced hepatic acute phase response
20019835 Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155)
20015877 The STAT3 signal pathway regulates cell proliferation in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma cells.
20012909 the activation of JAK/STAT3 pathway by GHRH
19995546 ERp57 is a necessary cofactor for the regulation of at least a subset of STAT3-dependent genes.
19968719 STAT3 activation is associated with Mcl-1 expression in nasal NK-cell lymphoma
19951849 findings suggest that overexpression of p-STAT3 (Tyr705) occurs in urothelial carcinoma, and that pathways other than SOCS3 may contribute to its activation in this cancer
19934272 The downregulation of miR-21 contributes to the antitumor effects of IFN-beta and that miR-21 expression is negatively regulated by STAT3 activation.
19915152 This study demonstrates in a cellular model and in patients with tuberculosis that in addition to p38 and NF-kappaB, STAT3 has a key role in driving fibroblast-dependent unopposed MMP-1 production that may be key in tissue destruction in patients.
19913854 the human SREBP-1c promoter was positively regulated by insulin and negatively regulated by STAT3.
19913121 Observational study of gene-disease association. (HuGE Navigator)
19903771 data suggest an important role for the negative regulatory effect of PIAS3 on STAT3 in EGF-driven tumors
19901516 Studies indicate that signaling pathways of STAT3, NOTCH, hedgehog and transforming growth factor-beta (TGFbeta), which are involved in stem cell renewal, differentiation, survival, and are commonly deregulated in HCC.
19901082 A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.
19900287 Data suggest that the percentage of peripheral blood mononuclear cells displaying p-STAT-3 may be increased in malignant glioma patients.
19889776 Elevated levels of STAT3 protein are characteristic of Burkitt lymphoma cells refractory sto EBV lytic cycle induction by HDAC inhibitors.
19878271 baicalein not only inhibited IL-6-mediated phosphorylation of signaling proteins, such as Jak, STAT3, MAPK, and Akt, but also inhibited the expression of their target genes, such as bcl-xl.
19876927 detected ERalpha binding to STAT3 and JAK2 (Janus kinase 2), resulting in enhanced JAK2 activity upstream of STAT3 in response to leptin that might lead to an increased ERalpha-dependent cell viability
19875458 STAT3 as a novel mediator of nutrient signals and identifies a Ser(727) phosphorylation-dependent and Tyr(705) phosphorylation-independent STAT3 activation mechanism in the modulation of insulin signaling.
19861958 Observational study of gene-disease association. (HuGE Navigator)
19861436 analysis of reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer
19851315 STAT3 has this dual role in tumour inflammation and immunity by promoting pro-oncogenic inflammatory pathways.
19843641 tumor-associated STAT3 is silenced by an oncolytic adenovirus
19825993 Taken together, these data show that mt p53 (G199V) gains antiapoptotic function mediated by STAT3 in ATC cells.
19824884 Studies suggest that a STAT3-SCLIP interaction is required to preserve SCLIP stability and contributes to the maintenance of normal epithelial morphology.
19819066 STAT3 is a weak anti-apoptotic agent
19817957 Observational study of gene-disease association. (HuGE Navigator)
19796718 The Stat3/5-dependent activation of cytokine expression in osteoblasts may have a significant impact on cancer cell migration and proliferation, but also on osteoclast activation.
19789299 ATRA blocks Squamous cell carcinoma (SCC) of the skin tumor formation, at least in part, by targeting events upstream of Stat3
19789190 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19781967 Molecular dynamics simulations were performed in explicit water of the activated Stat3 homodimer, and also its closely related member of the STAT family, activated Stat1 homodimer.
19781773 deguelin presents a potent anti-proliferative effect in part via the down-regulation of survivin expression and STAT3 phosphorylation in HTLV-1-transformed cells.
19776189 STAT3 gene polymorphisms influences the risk of abdominal obesity, which is modulated by dietary saturated fat inttake.
19776189 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19764570 STAT3 played an important role in the response and signal transduction of bronchial epithelial cells to the cyclic mechanical stretch stimulation through the phosphorylation of STAT3 Tyr705.
19764561 Tensile stress can activate the expression of p-ERK and p-STAT3 in alveolar epithelium A549 cells.
19760754 Observational study of gene-disease association. (HuGE Navigator)
19758315 The upregulation of IL-8 production is caused by constitutive STAT3 activation at the level of gene transcription in melanoma cells.
19751774 Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis.
19741199 cholinergic agonists suppress IL-6-mediated endothelial cell activation through the JAK2/STAT3 pathway
19741197 we have identified a novel regulatory pathway involving increased gene expression of the SNAT2 isoform mediated by a STAT-dependent pathway, which links IL-6 to increased activity of amino acid transporter system A
19730683 Observational study of gene-disease association. (HuGE Navigator)
19724924 Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas.
19723038 aStudies indicate that the phosphorylation of STAT-3 at serine 727 may regulate its activity negatively or positively.
19718269 data suggests that, in at least certain cellular microenvironments, cell:cell interactions represent a novel way to activate STAT3 signaling, uncouple APC activation events and consequently regulate immunity and tolerance
19717292 Studies have demonstrated that mutations in STAT3 and TYK2 genes result in Hyper-IgE syndrome (HIES.
19691533 chronic inflammatory demyelinating polyradiculoneuropathy(CDIP)patients with active disease showed higher pSTAT1, T-bet, & pSTAT3 in CD4(+) T-cells & monocytes than controls
19684620 This study not only reveals a role of CRT in motility promotion and anoikis resistance in ESCC cells, but also identifies CRT as an upstream regulator in the CRT-STAT3-CTTN-Akt pathway.
19667270 Studies indicate that a better understanding of the mechanisms of dysregulation of the STAT pathway and leukemogenesis may serve as a basis for designing novel therapeutic strategies directed against STATs.
19667218 Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19664131 pSTAT3tyr705 may be a novel prognostic marker for poorer clinical outcome following curative resection and adjuvant therapy in gastric cancer
19658181 These data suggest that STAT3 regulates the growth and self-renewal of GBM-SCs and is thus a potential target for cancer stem cell-directed therapy of glioblastoma multiforme.
19653082 TYK2 and STAT3 are genetic determinants of Crohn's disease in the Japanese population.
19653082 Observational study of gene-disease association. (HuGE Navigator)
19652645 Cholestasis or its important component-hydrophobic bile acids-can downregulate hepcidin expression through inhibiting IL-6-induced STAT3 phosphorylation and pSTAT3 protein nuclear translocation.
19647363 STAT3 has a critical role in regulating ovarian cancer cell motility and this process can be prevented by curcumin.
19642906 Data show that restoration of GRIM-19 levels reestablishes the control over STAT3-dependent gene expression and tumor growth in vivo.
19638983 p-Stat3 expression in cervical cancer acts as a predictor of poor prognosis.
19632985 Data show that deletion of the C-terminal part of IL-22R dramatically decreased its ability to activate STAT3.
19626047 IL-6, but not IFN-gamma, could significantly impair the in vivo growth of STAT3-depleted human neoplastic T lymphocytes
19623660 hypoxia-induced STAT3 activation is responsible for chemoresistance.
19616846 study concludes that Stat3 controls a specific gene set in trophoblast-like JEG-3 cells
19616333 A431 cells (human squamous cell carcinoma cells with EGFr overexpression) were found to be sensitized to radiation after treatment with STAT-3 small interfering RNA (siRNA).
19608866 these findings support the enhancement of JAK3/STAT3 activation and cell growth in anaplastic lymphoma kinase positive - anaplastic large cell lymphoma via IL-21 signaling.
19608729 Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-kappaB, and STAT3 signaling pathways.
19603082 Lipopolysaccharide-squamous cell carcinoma-monocyte interactions induce cancer-supporting factors leading to rapid STAT3 activation.
19601811 Findings suggest that STAT3 might be an excellent target for therapeutic intervention in tumor metastases.
19601808 Studies indicate that STAT3 plays dual tumor suppressive and oncogenic roles in glial malignancy depending on the mutational profile of the tumor.
19595668 These results suggest that IkappaB-zeta is a negative regulator of STAT3, and demonstrate a novel mechanism in which a component of the NF-kappaB signaling pathway inhibits the activation of STAT3.
19578748 constitutively activated STAT3 regulates expression of MUC1, which mediates lung cancer cell survival and metastasis in vitro and in vivo.
19577286 mechanisms underlying different forms of hyper IgE syndrome and their functional outcome by investigating the incidence of STAT3 mutations and the competency of TH17 cell differentiation in a cohort of affected Turkish children were elucidated.
19574718 findings suggest that Stat3 and p53 are cooperatively involved in the development of renal cell carcinoma (RCC) but assessment of their mRNA expression may not be useful for predicting the prognosis of patients with RCC
19556508 malignant transformation by activated Ras is impaired without STAT3; STAT3 was detected in mitochondria; findings show STAT3 regulates a metabolic function in mitochondria, supporting Ras-dependent malignant transformation
19509418 Stat3 is an essential signaling component potentially contributing to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia caused by PTPN11 gain-of-function mutations
19506034 Data show that in the nucleus, the acetylated STAT3 dimer is associated with CD44 and binds to the cyclin D1 promoter, leading to increased cyclin D1 expression and cell proliferation.
19503092 Data show thatCypA and CypB both play pivotal roles, yet at different signaling levels, for Stat3 activation and function.
19492417 The EGF/PI3K/STAT3 signaling is identified as an essential pathway regulating VEGF and leptin expression in EGF-responsive colon cancer cells.
19491198 Using a model system of paired breast cancer cell lines, we found that coactivation of STAT5 and STAT3 leads to decreased proliferation and increased sensitivity to the paclitaxel and vinorelbine compared with cells that have only STAT3 activation.
19484147 Data show that blockade of endothelial cell-derived IL-6, CXCL8, or EGF by gene silencing or neutralizing antibodies inhibited phosphorylation of STAT3, Akt, and ERK in tumor cells, respectively.
19457567 Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways.
19447160 GATA-1 can reverse STAT3-mediated gamma-globin gene silencing in erythroid cells
19435463 Data show that ARHI could compete for Ran-importin binding and induce disruption of importin-binding to cargo proteins, including STAT3.
19429240 These findings suggest that kahweol inhibited A549 cell growth and induced apoptosis via down-regulation of STAT3 signaling pathway.
19424782 STAT3 is frequently found to be constitutively active in breast cancer and tumors can become addicted to STAT3. Review.
19423540 Observational study of gene-disease association. (HuGE Navigator)
19422935 Observational study of gene-disease association. (HuGE Navigator)
19421717 interactive effect between HPV 16/18 and transcriptional activation of STAT3 gene in cervical carcinogenesis
19421230 STAT3 protein has a major role in the oncogenic process of nasal-type NK-cell lymphomas, and may represent a promising therapeutical target.
19414409 activated STAT3 is highly present in glioma but not normal brain tissues
19403642 EGFR, NFkappaB, and STAT3 are required for human iNOS gene induction in proximal tubule cells in response to pressure or EGF, indicating a similar mechanism of activation.
19399415 There was a significant correlation between the expression of p-STAT3 and that of osteopontin in melanoma.
19393627 STAP-2 is phosphorylated at Tyr250 by Brk, and plays an important role in Brk-mediated STAT3 activation.
19390056 Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway.
19385051 The JAK3/ERK pathway may play an important role in epidermal growth factor induced MMP-9 expression in SKBR3 cells.
19372705 persistent activation and nuclear translocation but not upregulation of STAT3 occurs in ALS spinal cord microglia.
19362457 Focusing on how STAT3 work in concert with other transcription factors will hopefully provide a better mechanistic understanding of the pathogenesis of various autoimmune diseases.
19360334 Targeting Stat3 signaling using siRNA may serve as a novel therapeutic strategy for the treatment of breast cancers expressing constitutively activated Stat3.
19348930 A novel mutation in the linker domain of the signal transducer and activator of transcription 3 gene, p.Lys531Glu, in hyper-IgE syndrome.
19345327 Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors.
19341726 Data suggest that colorectal neoplasms are STAT3/pSTAT3 immunoreactive in a stage specific manner and STAT3 protects cancerous colorectal epithelial cells from apoptosis.
19331815 mTOR signaling is one major mechanism in a tightly regulated network of intracellular signal pathways including the JAK/STAT system to regulate invasion in human trophoblast cells by secretion of enzymes that remodel the extra-cellular matrix.