Tchem NNMT Nicotinamide N-methyltransferase

Protein Summary

Description

Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P40261

Gene Name

• NNMT

Ensembl ID

• ENST00000299964
• ENSP00000299964
• ENSG00000166741
• ENST00000535401
• ENSP00000441434

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.84
small molecule perturbation	0.81
disease	0.63
gene perturbation	0.59
transcription factor	0.57

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Nicotinamide N-methyltransferase

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Nicotinamide N-methyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.18   (req: < 5)

Gene RIFs: 97   (req: <= 3)

Antibodies: 429   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.18   (req: >= 5)

Gene RIFs: 97   (req: > 3)

Antibodies: 429   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 66

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0