Property Summary

NCBI Gene PubMed Count 60
PubMed Score 108.99
PubTator Score 99.65

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 6.03711730773994E-13
juvenile dermatomyositis 1189 1.61652037784521E-12
posterior fossa group A ependymoma 1511 7.91922758628168E-10
acute quadriplegic myopathy 1157 8.39809171484503E-10
Duchenne muscular dystrophy 602 2.90992810154717E-8
pituitary cancer 1972 9.6740532196973E-8
Amyotrophic Lateral Sclerosis 432 2.95117083824881E-6
lung cancer 4473 5.60461443667925E-6
ulcerative colitis 2087 6.08951746124657E-6
interstitial cystitis 2299 3.13676959670053E-5
pediatric high grade glioma 2712 9.64218841401759E-5
head and neck cancer 270 1.36226154356376E-4
ovarian cancer 8492 2.30147734053814E-4
pancreatic cancer 2300 2.45997915289011E-4
limb girdle muscular dystrophy 2B 74 2.85862345003127E-4
primary pancreatic ductal adenocarcinoma 1271 4.46871694272229E-4
glioblastoma 5572 5.04480851992468E-4
cystic fibrosis 1670 6.33782059828022E-4
autosomal dominant Emery-Dreifuss muscular dystrophy 499 7.33936112230897E-4
gastric carcinoma 832 0.00113302125683219
pilocytic astrocytoma 3086 0.00319843739588567
Becker muscular dystrophy 187 0.00476273337286796
head and neck cancer and chronic obstructive pulmonary disease 237 0.00616408935254651
psoriasis 6685 0.0071050796710543
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00784853220390724
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00959520438877674
non diabetic and post-ischemic heart failure 200 0.0100027407721385
mucosa-associated lymphoid tissue lymphoma 480 0.0226225021397029
facioscapulohumeral dystrophy 286 0.0258735043670939
esophageal adenocarcinoma 737 0.0357452961011584
dermatomyositis 967 0.0466764463745805
Disease Target Count Z-score Confidence
Pellagra 25 3.196 1.6
Cancer 2346 3.175 1.6
Parkinson's disease 364 3.004 1.5



Accession P40261


PANTHER Protein Class (2)


2IIP   3ROD  

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Opossum OMA Inparanoid
Platypus OMA Inparanoid
C. elegans OMA Inparanoid

Gene RIF (51)

26571212 Data show that nicotinamide N-methyltransferase (NNMT) and the metabolic state regulate pluripotency in embryonic stem cells (hESCs).
26456643 results further reinforce a central role for NNMT in the regulation of energy homeostasis and provide further mechanistic insight into the consequences of enhanced NNMT expression
26168293 increasing Nnmt expression or MNAM levels stabilizes sirtuin 1 protein, an effect that is required for their metabolic benefits
25596852 White adipose tissue NNMT expression is regulated in human insulin resistance and type 2 diabetes and that plasma MNA correlates with increased tissue NNMT expression and the degree of insulin resistance.
25592232 Data sugguest that NNMT plays an important role in PANC-1 cell proliferation, metastatic potential and survival under metabolic stress.
25547204 There were no associations between MTHFR C677T, NNMT rs694539 AG/AA polymorphisms and conotruncal heart disease.
25317069 results suggest that the NNMT SNP rs694539 may have a role in the etiology of schizophrenia in a Han Chinese female population
25204218 The downregulation of NNMT significantly reduced in vitro tumorigenicity of A549 cells.
25201588 NNMT enhances the capacity of tumorigenesis associated with the inhibition of cell apoptosis and the promotion of cell cycle progression in human colorectal cancer cells
25115443 NNMT is associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis.

AA Sequence


Text Mined References (63)

PMID Year Title
26571212 2015 The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.
26456643 2015 Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3.
26168293 2015 Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization.
25596852 2015 Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance.
25592232 2015 Effects of nicotinamide N-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress.
25547204 2015 Association of MTHFR A1298C polymorphism with conotruncal heart disease.
25317069 2014 Female specific association between NNMT gene and schizophrenia in a Han Chinese population.
25204218 2015 Role of nicotinamide N-methyltransferase in non-small cell lung cancer: in vitro effect of shRNA-mediated gene silencing on tumourigenicity.
25201588 2014 Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells.
25115443 2014 N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis.