Tbio | Carcinoembryonic antigen-related cell adhesion molecule 3 |
Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.
This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
Comments
Disease | Target Count | P-value |
---|---|---|
psoriasis | 6685 | 7.83355024519694E-17 |
osteosarcoma | 7933 | 6.11195876707216E-6 |
non primary Sjogren syndrome sicca | 840 | 0.0153466464139837 |
Disease | log2 FC | p |
---|---|---|
osteosarcoma | -2.364 | 0.000 |
non primary Sjogren syndrome sicca | 1.100 | 0.015 |
psoriasis | 1.900 | 0.000 |
PMID | Text |
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26556959 | Demonstrated the CEACAM3 specificity and a perioperative trend of circulating tumor cells which is coherent with the clinical/pathological considerations in colorectal cancer. |
26162539 | COLIV is a promising tumour marker for CLM and can possibly be used to detect postoperative CLM recurrence. The combination of COLIV and CEA is superior to either marker alone in detecting CLM |
23630956 | A failure of CEACAM3-mediated innate immune detection might be linked to the ability of gonococci to cause disseminated infections. |
22948154 | Grb14 is the first negative regulator of CEACAM3-initiated bacterial phagocytosis and might help to focus granulocyte responses to the subcellular sites of pathogen-host cell contact |
22469950 | CEACAM3 promotes opsonin-independent phagocytosis of CEACAM-binding bacteria. CEACAM3 is the main driver for this process on human granulocytes. |
22382453 | The higher expression of CD44v6, integrin-beta1, CA199, and CEA are closely related to the progression and metastasis of pancreatic cancer.[CA199, CD44v6] |
22064717 | The authors show that the expression of CEACAM1 and CEACAM6 potentiate CEACAM3-dependent responses of neutrophils, exposing a cooperative role for this family of proteins during neisserial infection of neutrophils. |
21216968 | the ability of CEACAM3 to coordinate signaling events that not only mediate bacterial uptake, but also trigger the killing of internalized pathogens. |
20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
20373053 | the prognostic value of preoperative serum carbohydrate antigen19-9, carcinoembryonic antigen, and carbohydrate antigen 125 for overall survival in patients with colorectal cancer was studied |
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PMID | Year | Title |
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26556959 | 2015 | The Trend of CEACAM3 Blood Expression as Number Index of the CTCs in the Colorectal Cancer Perioperative Course. |
26162539 | 2015 | Improved tumour marker sensitivity in detecting colorectal liver metastases by combined type IV collagen and CEA measurement. |
23630956 | 2013 | Innate recognition by neutrophil granulocytes differs between Neisseria gonorrhoeae strains causing local or disseminating infections. |
22948154 | 2012 | Grb14 is a negative regulator of CEACAM3-mediated phagocytosis of pathogenic bacteria. |
22469950 | 2012 | HemITAM signaling by CEACAM3, a human granulocyte receptor recognizing bacterial pathogens. |
22382453 | 2012 | The efficacy evaluation of cryosurgery in pancreatic cancer patients with the expression of CD44v6, integrin-?1, CA199, and CEA. |
22064717 | 2012 | Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae. |
21216968 | 2011 | Phosphatidylinositol 3'-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis. |
20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
20373053 | 2011 | Preoperative serum carbohydrate antigen 125 level is an independent negative prognostic marker for overall survival in colorectal cancer. |
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