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Tbio
DCT
L-dopachrome tautomerase

Protein Summary
Description
Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377028
  • ENSP00000366227
  • ENSG00000080166
  • ENST00000446125
  • ENSP00000392762

Symbol
  • TYRP2
  • TRP-2
  • TYRP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
gene perturbation
0.77
cell type or tissue
0.7
disease
0.64
biological process
0.63


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.94   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.94   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0