Property Summary

NCBI Gene PubMed Count 45
PubMed Score 26.72
PubTator Score 44.61

Knowledge Summary


No data available


  Disease Sources (5)

Disease Target Count
Fleck retina, familial benign 1
Disease Target Count P-value
lung adenocarcinoma 2714 3.6482620670248E-13
sonic hedgehog group medulloblastoma 1482 2.51439137707362E-8
glioblastoma multiforme 347 1.34670458924294E-6
medulloblastoma, large-cell 6234 9.64331678142374E-5
atypical teratoid / rhabdoid tumor 4369 7.33224121491838E-4
lung cancer 4473 0.00121456989613838
primitive neuroectodermal tumor 3031 0.00202836275149955
invasive ductal carcinoma 2950 0.0108744318606548
astrocytic glioma 2241 0.0177421477538466
osteosarcoma 7933 0.0254612656114102
ependymoma 2514 0.040492078174541
oligodendroglioma 2849 0.0438864685684261
Disease Target Count Z-score Confidence
Thyroid cancer 25 0.0 1.0
Disease Target Count Z-score Confidence
Fundus Albipunctatus 8 3.515 1.8
Disease Target Count
Familial benign flecked retina 1


  Differential Expression (12)

Disease log2 FC p
astrocytic glioma -1.900 0.018
ependymoma -1.900 0.040
oligodendroglioma -1.700 0.044
glioblastoma multiforme 1.300 0.000
osteosarcoma -1.671 0.025
sonic hedgehog group medulloblastoma -3.200 0.000
atypical teratoid / rhabdoid tumor -2.000 0.001
medulloblastoma, large-cell -3.000 0.000
primitive neuroectodermal tumor -2.700 0.002
lung cancer -1.200 0.001
lung adenocarcinoma -1.100 0.000
invasive ductal carcinoma -1.200 0.011


Accession P39877 Q8N435
Symbols FRFB


PANTHER Protein Class (3)



  Ortholog (6)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Chicken OMA EggNOG

Gene RIF (29)

25549071 The clinical findings in this family suggest a diagnosis of benign familial fleck retina with excellent prognosis, in which the PLA2G5 gene may play a role.
25247183 Summarizing, Der p1 and Fel d1 involve phospholipase A2 enzymes in their action.
25132377 expression of PLA2s-IIE and -V correlates with the development of calcification as well as the expression of pro-osteogenic molecules in human aortic valves
25069533 sPLA2-V plays a thrombogenic role by impairing the ability of EPCR to promote protein C activation.
24959594 Our results demonstrate the association of the PLA2G5 rs11573191 polymorphism with premature CAD. In our study, it was possible to distinguish one haplotype associated with increased risk of premature CAD and hypertension.
24563418 There is no association between rs525380 polymorphism of PLA2G5 and coronary heart disease.
24495480 results demonstrate that EPCR is overexpressed and mediates the aggressive behavior of rheumatoid synovial fibroblasts, and is likely driven by group V secretory phospholipase A2
24042857 Human group V secretory phospholipase A2 is associated with lipid rafts and internalized in a flotillindependent pathway.
23650617 Our studies identified a unique function of gV-sPLA2 in activation of macrophages
22137173 Biallelic mutations in PLA2G5, encoding group V phospholipase A2, cause benign fleck retina

AA Sequence


Text Mined References (45)

PMID Year Title
25549071 2015 Phospholipase A2 group v in benign familial fleck retina in a set of triplets.
25247183 2014 The step further to understand the role of cytosolic phospholipase A2 alpha and group X secretory phospholipase A2 in allergic inflammation: pilot study.
25132377 2014 The expression of groups IIE and V phospholipase A2 is associated with an increased expression of osteogenic molecules in human calcified aortic valves.
25069533 2014 Group V secretory phospholipase A2 impairs endothelial protein C receptor-dependent protein C activation and accelerates thrombosis in vivo.
24959594 2014 The (G>A) rs11573191 polymorphism of PLA2G5 gene is associated with premature coronary artery disease in the Mexican Mestizo population: the genetics of atherosclerotic disease Mexican study.
24563418 2014 Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels.
24495480 2014 Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2.
24042857 2013 Human group V secretory phospholipase A2 is associated with lipid rafts and internalized in a flotillin?dependent pathway.
23650617 2013 Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
22837859 Group V phospholipase A(2) increases pulmonary endothelial permeability through direct hydrolysis of the cell membrane.