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Tclin
GRIK1
Glutamate receptor ionotropic, kainate 1

Protein Summary
Description
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389125
  • ENSP00000373777
  • ENSG00000171189
  • ENST00000399907
  • ENSP00000382791

Symbol
  • GLUR5
  • EAA3
  • EEA3
  • GLR5
  • GLUR5
  • GluK1
  • gluR-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.94
trait
0.93
molecular function
0.81
cellular component
0.76
disease
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 407   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 407   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 160
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3