Tbio ATP6V1A V-type proton ATPase catalytic subunit A

Protein Summary

Description

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857). This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P38606
• B2RBR8
• B7Z1R5
• D3DN75
• Q53YD9
• Q96DY6
• Q9UHY3
• V-ATPase subunit A

Gene Name

• ATP6V1A

Ensembl ID

• ENST00000273398
• ENSP00000273398
• ENSG00000114573

Symbol

• ATP6A1
• ATP6V1A1
• VPP2
• HO68
• VA68
• VPP2
• Vma1
• ARCL2D
• ATP6A1
• IECEE3
• ATP6V1A1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
molecular function	1
interacting protein	0.98
protein domain	0.97
transcription factor perturbation	0.97

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / V-type Proton Atpase Catalytic Subunit A

Protein / Transporter / Ion Channel / Anion Channel / V-type Proton Atpase Catalytic Subunit A

Protein / Transporter / Cation Transporter / Atp Synthase / V-type Proton Atpase Catalytic Subunit A

Protein / Receptor / Ligand-gated Ion Channel / V-type Proton Atpase Catalytic Subunit A

Protein / Nucleic Acid Binding / Dna Binding Protein / V-type Proton Atpase Catalytic Subunit A

Protein / Hydrolase / Protease / V-type Proton Atpase Catalytic Subunit A

DTO Classes

Protein / Transporter / F-type And V-type Atpases / V-type Atpase / V-type Proton Atpase Catalytic Subunit A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.91   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 167   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.91   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0