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Tbio
SPAM1
Hyaluronidase PH-20

Protein Summary
Description
Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223028
  • ENSP00000223028
  • ENSG00000106304
  • ENST00000340011
  • ENSP00000345849
  • ENST00000402183
  • ENSP00000386028
  • ENST00000439500
  • ENSP00000402123
  • ENST00000460182
  • ENSP00000417934

Symbol
  • HYAL3
  • PH20
  • HYA1
  • PH20
  • HYAL1
  • HYAL3
  • HYAL5
  • PH-20
  • SPAG15
  • HEL-S-96n
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.6
gene perturbation
0.59
protein domain
0.58
cell type or tissue
0.45
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.91   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.91   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0