Tbio IFNGR2 Interferon gamma receptor 2

Protein Summary

Description

Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114). This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P38484
• Q9BTL5
• IFN-gamma receptor 2

Gene Name

• IFNGR2

Ensembl ID

• ENST00000290219
• ENSP00000290219
• ENSG00000159128
• ENST00000576463
• ENSP00000458487
• ENSG00000262795

Symbol

• IFNGT1
• AF-1
• IFGR2
• IMD28
• IFNGT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
kinase perturbation	0.93
transcription factor perturbation	0.91
transcription factor binding site profile	0.77
PubMedID	0.76

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Gamma Receptor 2

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interferon Gamma Receptor 2

Protein / Defense/immunity Protein / Interferon Gamma Receptor 2

DTO Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Interferon Gamma Receptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.16   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 383   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.16   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 383   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0