AVPR1A
Vasopressin V1a receptor
Protein Summary
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]
- ENST00000299178
- ENSP00000299178
- ENSG00000166148
- AVPR1
- V1aR
- AVPR1
- AVPR V1a
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 1 | ||
biological process | 0.99 | ||
molecular function | 0.81 | ||
phenotype | 0.77 | ||
gene perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 363.35 (req: < 5)
Gene RIFs: 78 (req: <= 3)
Antibodies: 254 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 363.35 (req: >= 5)
Gene RIFs: 78 (req: > 3)
Antibodies: 254 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 33
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 592
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 9