Tbio NUP62 Nuclear pore glycoprotein p62

Protein Summary

Description

Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P37198
• B3KWU5
• Q503A4
• Q6GTM2
• Q96C43
• Q9NSL1

Gene Name

• NUP62

Ensembl ID

• ENST00000352066
• ENSP00000305503
• ENSG00000213024
• ENST00000422090
• ENSP00000407331
• ENST00000596217
• ENSP00000471191
• ENST00000597029
• ENSP00000473192

Symbol

• p62
• IBSN
• SNDI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
disease perturbation	0.99
biological process	0.98
co-expressed gene	0.94
kinase perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Transporter / Nuclear Pore Glycoprotein P62

DTO Classes

Protein / Transporter / Nuclear Pore Glycoprotein P62

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.84   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 329   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.84   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0