Tchem HSD17B3 Testosterone 17-beta-dehydrogenase 3

Protein Summary

Description

Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P37058
• Q5U0Q6

Gene Name

• HSD17B3

Ensembl ID

• ENST00000375262
• ENSP00000364411
• ENSG00000130948
• ENST00000375263
• ENSP00000364412

Symbol

• EDH17B3
• SDR12C2
• EDH17B3
• SDR12C2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.73
protein domain	0.58
co-expressed gene	0.57
disease	0.52
cellular component	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.26   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 177   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.26   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 152

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2