Tchem CHRNA7 Neuronal acetylcholine receptor subunit alpha-7

Protein Summary

Description

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• P36544
• A8K7Q4
• B4DFS0
• Q15826
• Q8IUZ4
• Q96RH2
• Q99555
• Q9BXH0

Gene Name

• CHRNA7

Ensembl ID

• ENST00000306901
• ENSP00000303727
• ENSG00000175344
• ENST00000437966
• ENSP00000399087
• ENST00000454250
• ENSP00000407546

Symbol

• NACHRA7
• NACHRA7
• CHRNA7-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Acetylcholine Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-7

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Gaba Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-7

Protein / Receptor / Ligand-gated Ion Channel / Acetylcholine Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-7

Protein / Receptor / Ligand-gated Ion Channel / Gaba Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-7

DTO Classes

Protein / Ion Channel / Neurotransmitter Receptor, Cys Loop, Ligand-gated Ion Channel (Lic) Family / Acetylcholine Receptor Subfamily / Alpha-7/chrna7 Sub-subfamily / Neuronal Acetylcholine Receptor Subunit Alpha-7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.45   (req: < 5)

Gene RIFs: 256   (req: <= 3)

Antibodies: 288   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.45   (req: >= 5)

Gene RIFs: 256   (req: > 3)

Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 905

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11