Tclin MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2

Protein Summary

Description

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P36507
• MAP kinase kinase 2

Gene Name

• MAP2K2

Ensembl ID

• ENST00000262948
• ENSP00000262948
• ENSG00000126934

Symbol

• MEK2
• MKK2
• PRKMK2
• CFC4
• MEK2
• MKK2
• MAPKK2
• PRKMK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
pathway	1
hub protein	0.98
chemical	0.95
biological process	0.94

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste7 Family / Dual Specificity Mitogen-activated Protein Kinase Kinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.11   (req: < 5)

Gene RIFs: 108   (req: <= 3)

Antibodies: 1236   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.11   (req: >= 5)

Gene RIFs: 108   (req: > 3)

Antibodies: 1236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6