Tbio SLC16A2 Monocarboxylate transporter 8

Protein Summary

Description

Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr. This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• P36021
• Q7Z797
• MCT 8

Gene Name

• SLC16A2

Ensembl ID

• ENST00000587091
• ENSP00000465734
• ENSG00000147100

Symbol

• MCT8
• XPCT
• AHDS
• MCT7
• MCT8
• XPCT
• MCT 7
• MCT 8
• MRX22
• DXS128
• DXS128E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.83
PubMedID	0.77
histone modification site profile	0.69
disease perturbation	0.68
gene perturbation	0.65

Protein Classes

PANTHER Classes

Protein / Transporter / Monocarboxylate Transporter 8

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc16 Family Of Monocarboxylate Transporters / Monocarboxylate Transporter 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.29   (req: < 5)

Gene RIFs: 65   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.29   (req: >= 5)

Gene RIFs: 65   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0