Tclin FLT4 Vascular endothelial growth factor receptor 3

Protein Summary

Description

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35916
• A8K6L4
• B5A926
• Q16067
• Q86W07
• Q86W08
• VEGFR-3

Gene Name

• FLT4

Ensembl ID

• ENST00000261937
• ENSP00000261937
• ENSG00000037280
• ENST00000393347
• ENSP00000377016

Symbol

• VEGFR3
• PCL
• FLT-4
• FLT41
• LMPH1A
• LMPHM1
• VEGFR3
• VEGFR-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
biological process	0.87
PubMedID	0.77
biological term	0.72

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Vegfr Family / Vascular Endothelial Growth Factor Receptor 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 812.85   (req: < 5)

Gene RIFs: 215   (req: <= 3)

Antibodies: 968   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 812.85   (req: >= 5)

Gene RIFs: 215   (req: > 3)

Antibodies: 968   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 217

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8