Tclin PDE6B Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

Protein Summary

Description

This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme. Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• P35913
• B7Z9T9
• E7ETT3
• Q53XN5
• Q9BWH5
• Q9UD49
• GMP-PDE beta

Gene Name

• PDE6B

Ensembl ID

• ENST00000255622
• ENSP00000255622
• ENSG00000133256
• ENST00000429163
• ENSP00000406334
• ENST00000496514
• ENSP00000420295

Symbol

• PDEB
• rd1
• PDEB
• RP40
• CSNB3
• CSNBAD2
• GMP-PDEbeta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
protein domain	0.85
biological process	0.71
co-expressed gene	0.69
tissue	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1075.01   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1075.01   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1