Tclin AHR Aryl hydrocarbon receptor

Protein Summary

Description

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• P35869
• A4D130
• Q13728
• Q13803
• Q13804
• Ah receptor

Gene Name

• AHR

Ensembl ID

• ENST00000242057
• ENSP00000242057
• ENSG00000106546
• ENST00000463496
• ENSP00000436466

Symbol

• BHLHE76
• RP85
• bHLHe76

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
biological process	0.87
molecular function	0.86
disease	0.84
microRNA	0.8

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Aryl Hydrocarbon Receptor

Protein / Receptor / Aryl Hydrocarbon Receptor

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Aryl Hydrocarbon Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.36   (req: < 5)

Gene RIFs: 625   (req: <= 3)

Antibodies: 967   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.36   (req: >= 5)

Gene RIFs: 625   (req: > 3)

Antibodies: 967   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1