IGFALS
Insulin-like growth factor-binding protein complex acid labile subunit
Protein Summary
Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion. The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
- ENST00000215539
- ENSP00000215539
- ENSG00000099769
- ENST00000415638
- ENSP00000416683
- ALS
- ALS
- ACLSD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.66 | ||
cell line | 0.6 | ||
protein domain | 0.58 | ||
gene perturbation | 0.55 | ||
transcription factor | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.34 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 232 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.34 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 232 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0