Property Summary

NCBI Gene PubMed Count 229
PubMed Score 554.56
PubTator Score 462.91

Knowledge Summary


No data available


  Disease Sources (5)

Disease Target Count P-value
lung carcinoma 2844 1.58837214559364E-12
lung adenocarcinoma 2714 2.69422532878497E-12
non-small cell lung cancer 2798 1.46648329236299E-11
pilocytic astrocytoma 3086 3.55981401269799E-11
ovarian cancer 8492 1.36125888762628E-8
malignant mesothelioma 3163 5.54678417125605E-7
lung cancer 4473 7.76028422343094E-6
intraductal papillary-mucinous carcinoma (IPMC) 2988 3.4072471635363E-5
psoriasis 6685 5.05928071759107E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 6.7715376542079E-5
pancreatic cancer 2300 8.75661338005826E-5
primary pancreatic ductal adenocarcinoma 1271 1.35570992642459E-4
glioblastoma 5572 1.44689259560766E-4
cystic fibrosis 1670 1.49215488132134E-4
group 4 medulloblastoma 1875 3.32484362249641E-4
pediatric high grade glioma 2712 3.7942056710596E-4
ductal carcinoma in situ 1745 6.45311961366851E-4
astrocytoma 1493 0.00107344997600797
breast carcinoma 1614 0.00136018133865976
ulcerative colitis 2087 0.00157991111404284
Down syndrome 548 0.00162898145531086
osteosarcoma 7933 0.00199018982813335
limb girdle muscular dystrophy 2I 56 0.00524242591102893
non primary Sjogren syndrome sicca 840 0.00556797625807005
oligodendroglioma 2849 0.00639265477376484
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00653389162229742
primitive neuroectodermal tumor 3031 0.0104205705214933
Atopic dermatitis 944 0.0121172952931898
fibroadenoma 557 0.0172796437711661
invasive ductal carcinoma 2950 0.0201451762621688
adrenocortical carcinoma 1427 0.0248795080426594
gastric carcinoma 832 0.0291100236043814
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.0392631244956002
Disease Target Count Z-score Confidence
Age related macular degeneration 84 4.802 2.4



Accession P35625 B2RBY9 Q5THV4 Q9UC74 Q9UGS2
Symbols SFD




  Ortholog (11)

Gene RIF (192)

26872030 TIMP3 was validated as a direct target of miRNA-21 by dual-luciferase reporter assay. Silencing with small interfering RNA against TIMP3 promoted angiogenesis and increased MMP2 and MMP9 expression at the protein level.
26707830 TIMP3 is a dominant negative regulator of angiogenesis in cutaneous melanoma and gene silencing by promoter methylation is associated with poor outcome
26686417 Taken together, our results suggest that the imbalance between aggrecanase and TIMP-3 may play an important role in the pathogenesis of IDD and therefore be a potential therapeutic target for treating IDD.
26676407 expression of TIMP3 is low in pituitary adenomas including ACTH-secreting pituitary adenomas and negatively associated with tumor aggressiveness.
26579821 Results suggest that gene-environment interactions between the TIMP3 rs9862 polymorphisms and betel quid may alter oral cancer susceptibility and tumor growth in Taiwanese men.
26304100 Genotypes of rs135025 and rs80272 in TIMP3 contribute to the development of preeclampsia in Han Chinese women.
26123869 following acute ACL injury, an upregulation of TIMP-3, the primary aggrecanase inhibitor, is elicited in response to increased aggrecan degradation, which may inhibit further cleavage
26068512 Gene-gene interactions between Smad3 rs6494629T/C and TIMP3 rs715572G/A polymorphisms may play more important protective roles in knee OA.
25819812 The miR-191-TIMP3 axis might be critical in the malignant transformation of endometriosis to endometriosis-associated ovarian cancer.
25766588 This study expands the spectrum of mutations in the TIMP3 gene and associated phenotypic findings. Imaging using late-phase ICG-A may be useful for early identification of individuals at risk for developing SFD.

AA Sequence


Text Mined References (230)

PMID Year Title
26872030 2016 The Angiogenic Effect of microRNA-21 Targeting TIMP3 through the Regulation of MMP2 and MMP9.
26707830 2016 Association of TIMP3 expression with vessel density, macrophage infiltration and prognosis in human malignant melanoma.
26686417 2016 The imbalance between TIMP3 and matrix-degrading enzymes plays an important role in intervertebral disc degeneration.
26676407 2016 The Clinical Utility of TIMP3 Expression in ACTH-Secreting Pituitary Tumor.
26579821 2015 Polymorphisms and Plasma Levels of Tissue Inhibitor of Metalloproteinase-3: Impact on Genetic Susceptibility and Clinical Outcome of Oral Cancer.
26304100 2015 Contribution of TIMP3 polymorphisms to the development of preeclampsia in Han Chinese women.
26123869 2015 Relationship between synovial fluid ARGS-aggrecan fragments, cytokines, MMPs, and TIMPs following acute ACL injury: A cross-sectional study.
26068512 2015 Gene-gene interactions between TGF-?/Smad3 signalling pathway polymorphisms affect susceptibility to knee osteoarthritis.
25819812 2015 MiR-191 modulates malignant transformation of endometriosis through regulating TIMP3.
25766588 2015 Sorsby Fundus Dystrophy: Novel Mutations, Novel Phenotypic Characteristics, and Treatment Outcomes.