| Tchem | Tyrosine-protein kinase receptor Tie-1 |
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2798 | 1.77521787363128E-22 |
| lung adenocarcinoma | 2714 | 2.12411694811487E-17 |
| lung carcinoma | 2844 | 3.84190328121739E-10 |
| malignant mesothelioma | 3163 | 1.99453055151516E-7 |
| juvenile dermatomyositis | 1189 | 3.36250351790762E-7 |
| interstitial cystitis | 2299 | 4.41702296721491E-5 |
| lung cancer | 4473 | 7.67194851894935E-5 |
| psoriasis | 6685 | 2.26235142100361E-4 |
| cystic fibrosis | 1670 | 0.00117907884942041 |
| pituitary cancer | 1972 | 0.00143680870805884 |
| nephrosclerosis | 329 | 0.00192636850246479 |
| invasive ductal carcinoma | 2950 | 0.0025311315786337 |
| ductal carcinoma in situ | 1745 | 0.00594276301626926 |
| aldosterone-producing adenoma | 664 | 0.0120302808777628 |
| gastric carcinoma | 832 | 0.0136493750195395 |
| osteosarcoma | 7933 | 0.0293063186587274 |
| Disease | log2 FC | p |
|---|---|---|
| nephrosclerosis | 1.157 | 0.002 |
| malignant mesothelioma | 3.800 | 0.000 |
| psoriasis | -1.300 | 0.000 |
| osteosarcoma | -1.756 | 0.029 |
| cystic fibrosis | 1.179 | 0.001 |
| juvenile dermatomyositis | 1.163 | 0.000 |
| non-small cell lung cancer | -2.339 | 0.000 |
| lung cancer | -1.900 | 0.000 |
| interstitial cystitis | 1.700 | 0.000 |
| lung adenocarcinoma | -2.100 | 0.000 |
| aldosterone-producing adenoma | -1.086 | 0.012 |
| lung carcinoma | -1.600 | 0.000 |
| gastric carcinoma | 1.500 | 0.014 |
| ductal carcinoma in situ | -1.200 | 0.006 |
| invasive ductal carcinoma | -1.800 | 0.003 |
| pituitary cancer | -1.300 | 0.001 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG Inparanoid |
| Chicken | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 26489611 | The inhibition of Tie-2 exerted by Tie-1can be relieved by Tie-1 ectodomain cleavage mediated by tumor- and inflammatory-related factors, which causes destabilization of vessels and initiates vessel remodeling in cancer. (Review) |
| 26436659 | T794A-expressing human umbilical vein endothelial cells formed significantly shorter tubes with fewer branches in three-dimensional Matrigel cultures, but did not alter Tie1 or Tie2 tyrosine phosphorylation or downstream signaling. |
| 22987233 | The decreasing expression of Tie1 may play an important role in the pathogenesis of primary lower extremity varicose veins. |
| 22421998 | Data propose that EndMT associated with Tie1 downregulation participates in the pathological development of stroma observed in tumours. |
| 22342979 | these results suggest that the expression level of Tie1 and its physical interaction with Tie2 defines whether Ang2 functions as a Tie2 agonist or antagonist, thereby determining the context-dependent differential endothelial sensitivity to Ang2. |
| 22235284 | the effects of factors activating ectodomain cleavage on both Tie1 and Tie2 within the same population of cells, and their impact on angiopoietin signalling |
| 20628086 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 20346360 | Observational study of gene-disease association. (HuGE Navigator) |
| 20227369 | Provide evidence for Tie1-Tie2 complex formation on the cell surface and identify molecular surface areas essential for recognition. The Tie1-Tie2 interactions are dynamic, inhibitory, and differentially modulated by angiopoietin-1 and -2. |
| 20164029 | The Tie-1 immunoreactivity was dominantly observed in the heamangiogenic cells and cells cords, whereas the matured villi showed immunoreactivity only in other components. |
| More... |
MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPPLLLEKDDRIV 1 - 70 RTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVNKGD 71 - 140 TAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRL 141 - 210 IVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRG 211 - 280 LTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRI 281 - 350 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD 351 - 420 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDST 421 - 490 MDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTD 491 - 560 RLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTLLGP 561 - 630 ASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEE 631 - 700 TSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVS 701 - 770 ATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT 771 - 840 FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNR 841 - 910 GYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDL 911 - 980 AARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLG 981 - 1050 GTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNM 1051 - 1120 SLFENFTYAGIDATAEEA 1121 - 1138 //
| PMID | Year | Title |
|---|---|---|
| 26489611 | 2015 | Tie-1: A potential target for anti-angiogenesis therapy. |
| 26436659 | 2015 | Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 22987233 | 2013 | Abnormal expression of Tie1 on the valves of great saphenous varicose vein. |
| 22421998 | 2012 | Tie1 deficiency induces endothelial-mesenchymal transition. |
| 22342979 | 2012 | Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells. |
| 22235284 | 2012 | The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNF? and regulates angiopoietin signalling. |
| 22103492 | 2011 | Molecular control of angiopoietin signalling. |
| 21982860 | 2012 | A secreted protein microarray platform for extracellular protein interaction discovery. |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |
| More... |
