TIE1
Tyrosine-protein kinase receptor Tie-1
Protein Summary
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
- ENST00000372476
- ENSP00000361554
- ENSG00000066056
- ENST00000538015
- ENSP00000440063
- TIE
- TIE
- JTK14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.98 | ||
PubMedID | 0.73 | ||
co-expressed gene | 0.69 | ||
tissue sample | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 200.38 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 664 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 200.38 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 664 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0