| Tchem | Tyrosine-protein kinase receptor Tie-1 |
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.8e-22 |
| lung adenocarcinoma | 2716 | 4.8e-19 |
| lung carcinoma | 2843 | 3.8e-10 |
| malignant mesothelioma | 3232 | 2.0e-07 |
| juvenile dermatomyositis | 1187 | 3.4e-07 |
| interstitial cystitis | 2312 | 4.4e-05 |
| psoriasis | 6694 | 2.3e-04 |
| cystic fibrosis | 1696 | 1.2e-03 |
| pituitary cancer | 1972 | 1.4e-03 |
| nephrosclerosis | 333 | 1.9e-03 |
| invasive ductal carcinoma | 2951 | 2.5e-03 |
| ductal carcinoma in situ | 1745 | 5.9e-03 |
| aldosterone-producing adenoma | 665 | 1.2e-02 |
| gastric carcinoma | 807 | 1.4e-02 |
| lung cancer | 4740 | 2.0e-02 |
| osteosarcoma | 7950 | 2.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| aldosterone-producing adenoma | -1.086 | 1.2e-02 |
| cystic fibrosis | 1.179 | 1.2e-03 |
| ductal carcinoma in situ | -1.200 | 5.9e-03 |
| gastric carcinoma | 1.500 | 1.4e-02 |
| interstitial cystitis | 1.700 | 4.4e-05 |
| invasive ductal carcinoma | -1.800 | 2.5e-03 |
| juvenile dermatomyositis | 1.163 | 3.4e-07 |
| lung adenocarcinoma | -1.500 | 4.8e-19 |
| lung cancer | -1.400 | 2.0e-02 |
| lung carcinoma | -1.600 | 3.8e-10 |
| malignant mesothelioma | 3.800 | 2.0e-07 |
| nephrosclerosis | 1.157 | 1.9e-03 |
| non-small cell lung cancer | -2.339 | 1.8e-22 |
| osteosarcoma | -1.756 | 2.9e-02 |
| pituitary cancer | -1.300 | 1.4e-03 |
| psoriasis | -1.300 | 2.3e-04 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
CHEMBL509032
pKd 7.82
CHEMBL103667
pKd 8.08
CHEMBL1230609
pKd 9.10
CHEMBL574738
pKd 9.54
merestinib
pKd 9.05
MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPPLLLEKDDRIV 1 - 70 RTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVNKGD 71 - 140 TAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRL 141 - 210 IVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRG 211 - 280 LTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRI 281 - 350 PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD 351 - 420 SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDST 421 - 490 MDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTD 491 - 560 RLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTLLGP 561 - 630 ASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEE 631 - 700 TSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVS 701 - 770 ATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT 771 - 840 FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNR 841 - 910 GYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDL 911 - 980 AARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLG 981 - 1050 GTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNM 1051 - 1120 SLFENFTYAGIDATAEEA 1121 - 1138 //
