Tclin | D(3) dopamine receptor |
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Comments
Property Summary
Ligand Count | 2,408 |
NCBI Gene PubMed Count | 356 |
PubMed Score | 312.30 |
PubTator Score | 382.09 |
Disease | Target Count |
---|---|
Schizophrenia | 1160 |
Chronic schizophrenia | 16 |
Nausea and vomiting | 97 |
Nonpsychotic Anxiety | 2 |
Prolonged-Severe Nausea and Vomiting | 2 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Alcohol dependence | 107 | 4.054 | 2.0 |
Opiate dependence | 29 | 0.0 | 5.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Essential tremor | 28 | 5.676 | 2.8 |
Attention deficit hyperactivity disorder | 278 | 4.119 | 2.1 |
Pathological gambling | 15 | 4.049 | 2.0 |
Parkinson's disease | 392 | 4.04 | 2.0 |
lingual-facial-buccal dyskinesia | 13 | 3.839 | 1.9 |
Substance abuse | 59 | 3.371 | 1.7 |
Disease | Target Count |
---|---|
TREMOR, HEREDITARY ESSENTIAL, 1 | 2 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
flunarizine
pIC50 7.01
dopamine
pKi 7.14
promazine
pKi 7.16
metoclopramide
pKi 7.17
oxatomide
pKi 7.20
ropinirole
pKi 7.22
methysergide
pKi 7.23
sulpiride
pKi 7.24
cisapride
pKi 7.31
buspirone
pIC50 7.36
ebastine
pKi 7.38
pramipexole
pKi 7.42
haloperidol
pKi 7.54
loxapine
pIC50 7.66
domperidone
pIC50 7.75
prochlorperazine
pIC50 7.89
chlorpromazine
pIC50 7.92
thioridazine
pIC50 8.01
clemastine
pIC50 8.14
chlorprothixene
pKi 8.34
prochlorperazine
pKi 8.61
amisulpride
pKi 8.49
CHEMBL418321
pKi 7.00
CHEMBL2037521
pKi 7.00
CHEMBL85
pKi 7.00
CHEMBL3780140
pKi 7.00
CHEMBL1774544
pKi 7.00
CHEMBL3799157
pKi 7.00
CHEMBL240773
pKi 7.00
CHEMBL2367896
pKi 7.00
CHEMBL325060
pKi 7.00
CHEMBL231070
pKi 7.00
CHEMBL42
pKi 7.00
CHEMBL715
pKi 7.00
CHEMBL326454
pKi 7.00
CHEMBL1631532
pKi 7.00
CHEMBL168908
pKi 7.00
CHEMBL1803055
pKi 7.00
CHEMBL595489
pKi 7.00
CHEMBL1173288
pKi 7.00
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVS 1 - 70 LAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQH 71 - 140 GTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYAR 141 - 210 IYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREE 211 - 280 KTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHV 281 - 350 LNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 351 - 400 //