Tclin D(3) dopamine receptor

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Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.

This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

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Property Summary

Ligand Count	2,408
NCBI Gene PubMed Count	356
PubMed Score	312.30

PubTator Score	382.09

Knowledge Summary

Patent (15,034)

TINX Plot

Disease (7)

Disease	Target Count	Z-score	Confidence
Autistic Disorder	364	3.174	1.6
Amphetamine-Related Disorders	74	0.0	0.0
Basal Ganglia Diseases	14	0.0	0.0
Cocaine-Related Disorders	92	0.0	0.0
Cognition Disorders	32	0.0	0.0
Disruptive, Impulse Control, and Conduct Disorders	3	0.0	0.0
Dyskinesia, Drug-Induced	15	0.0	0.0
Gambling	1	0.0	0.0
Hyperalgesia	83	0.0	0.0
Hyperkinesis	32	0.0	0.0
Movement Disorders	55	0.0	0.0
Seizures	596	0.0	0.0
Tourette Syndrome	4	0.0	0.0
Tremor hereditary essential, 1	1	0.0	0.0

Disease	Target Count
Bipolar Disorder	666
Cocaine Dependence	51
Gilles de la Tourette syndrome	47
Alcohol abuse	50
Alcoholic Intoxication, Chronic	289
Cocaine abuse	19
Delirium	10
Depressive disorder	409
Hyperactive behavior	91
Major Depressive Disorder	301
Mental Depression	333
Mood Disorders	184
Recurrent depression	9
Unipolar Depression	250

Disease	Target Count
Schizophrenia	1160
Chronic schizophrenia	16
Nausea and vomiting	97
Nonpsychotic Anxiety	2
Prolonged-Severe Nausea and Vomiting	2

Disease	Target Count	Z-score	Confidence
Carcinoma	11493	0.0	0.6

Disease	Target Count	Z-score	Confidence
Alcohol dependence	107	4.054	2.0
Opiate dependence	29	0.0	5.0

Disease	Target Count	Z-score	Confidence
Essential tremor	28	5.676	2.8
Attention deficit hyperactivity disorder	278	4.119	2.1
Pathological gambling	15	4.049	2.0
Parkinson's disease	392	4.04	2.0
lingual-facial-buccal dyskinesia	13	3.839	1.9
Substance abuse	59	3.371	1.7

Disease	Target Count
TREMOR, HEREDITARY ESSENTIAL, 1	2

Brain - Nucleus accumbens (basal ganglia... 18,024

Testis 18,518

Brain - Caudate (basal ganglia) 18,001

Brain - Putamen (basal ganglia) 17,863

Brain - Amygdala 18,006

Brain - Hypothalamus 18,169

Adipose - Subcutaneous 18,110

Liver 18,071

Colon - Transverse 17,825

Spleen 17,614

Brain - Cerebellum 17,983

Brain - Hippocampus 18,011

Breast - Mammary Tissue 18,103

Thyroid 18,024

Brain - Frontal Cortex (BA9) 18,069

Brain - Anterior cingulate cortex (BA24) 17,989

Artery - Coronary 17,949

Prostate 18,213

Esophagus - Gastroesophageal Junction 18,000

Pancreas 18,123

Brain - Cortex 18,039

Minor Salivary Gland 18,005

Lung 18,057

Skin - Sun Exposed (Lower leg) 17,968

Brain - Substantia nigra 17,981

Esophagus - Mucosa 18,076

Colon - Sigmoid 18,089

Uterus 17,618

Skin - Not Sun Exposed (Suprapubic) 18,081

Nerve - Tibial 18,007

Ovary 17,971

Small Intestine - Terminal Ileum 17,954

Pituitary 18,147

Brain - Spinal cord (cervical c-1) 17,973

Cells - EBV-transformed lymphocytes 18,186

Whole Blood 17,439

Heart - Atrial Appendage 17,896

testis 17,936

Endocrine System 18,159

Brain 7,346

See source...

Dopaminergic system 43

Brain 1,516

Ganglion 334

See source...

Synonym

Accession	P35462 A1A4V5 Q4VBM8
Symbols	D3DR ETM1 FET1

Gene

DRD3

PANTHER Protein Class (2)

receptor 400

G-protein coupled receptor 221

Ortholog (12)

Species	Source	Disease
Chimp 14,140	Inparanoid OMA EggNOG
Macaque 12,761	OMA EggNOG
Mouse 16,570	Inparanoid OMA EggNOG
Rat 15,117	Inparanoid OMA
Dog 15,073	Inparanoid OMA EggNOG
Horse 14,252	Inparanoid OMA EggNOG
Cow 15,320	Inparanoid OMA EggNOG
Pig 10,168	OMA EggNOG
Opossum 12,230	Inparanoid OMA EggNOG
Chicken 7,827	OMA EggNOG
Anole lizard 10,588	Inparanoid OMA EggNOG
Zebrafish 9,726	Inparanoid OMA EggNOG

UniProt Keyword (15)

Complete proteome 20,231

Polymorphism 12,194

Reference proteome 20,231

Alternative splicing 10,528

Cell membrane 3,390

Disulfide bond 3,599

G-protein coupled receptor 830

Glycoprotein 4,623

Membrane 7,361

Receptor 1,502

See all...

GO Function (5)

protein domain specific binding 241

drug binding 75

D1 dopamine receptor binding 9

dopamine binding 13

dopamine neurotransmitter receptor activ... 8

GO Component (5)

plasma membrane 4,414

integral component of plasma membrane 1,418

apical part of cell 72

cell projection 87

endocytic vesicle 50

GO Process (46)

positive regulation of transcription fro... 932

G-protein coupled receptor signaling pat... 1,053

positive regulation of cell proliferatio... 470

negative regulation of transcription fro... 683

response to drug 303

response to morphine 28

regulation of lipid metabolic process 87

response to amphetamine 25

learning or memory 48

negative regulation of protein secretion 12

See all...

Compartment GO Term (14)

Cell 16,178

Cell part 16,177

Cell periphery 5,382

G-protein coupled receptor homodimeric c... 5

Integral component of membrane 5,331

Integral component of plasma membrane 1,693

Intrinsic component of membrane 5,458

Intrinsic component of plasma membrane 1,749

Membrane 8,531

Membrane part 6,554

Plasma membrane 5,830

Plasma membrane part 2,594

W chromosome 15

cellular_component 18,320

MGI Phenotype (9)

growth-size-body region phenotype 4,157

homeostasis-metabolism phenotype 4,747

digestive-alimentary phenotype 1,398

nervous system phenotype 3,447

cardiovascular system phenotype 2,660

mortality-aging 5,018

renal-urinary system phenotype 1,269

behavior-neurological phenotype 3,401

adipose tissue phenotype 992

GWAS Trait (2)

Personality dimensions 19

Smooth-surface caries 28

HCA RNA Cell Line (3)

RPMI-8226 16,015

SH-SY5Y 16,707

U-87 MG 16,285

Pathway (26)

Neuroactive ligand-receptor interaction 276

Dopaminergic synapse 135

http://pathwaycommons.org/pc2/Pathway_27... 235

http://pathwaycommons.org/pc2/Pathway_b5... 233

http://pathwaycommons.org/pc2/Pathway_db... 223

http://pathwaycommons.org/pc2/Pathway_ea... 224

http://pathwaycommons.org/pc2/Pathway_f3... 224

http://pathwaycommons.org/pc2/Pathway_f7... 223

http://pathwaycommons.org/pc2/Pathway_0c... 35

http://pathwaycommons.org/pc2/Pathway_69... 36

See all...

PDB (1)

...
More...

Drug (27)

flunarizine
pIC50 7.01

dopamine
pKi 7.14

promazine
pKi 7.16

metoclopramide
pKi 7.17

oxatomide
pKi 7.20

ropinirole
pKi 7.22

methysergide
pKi 7.23

sulpiride
pKi 7.24

cisapride
pKi 7.31

buspirone
pIC50 7.36

ebastine
pKi 7.38

pramipexole
pKi 7.42

haloperidol
pKi 7.54

loxapine
pIC50 7.66

domperidone
pIC50 7.75

prochlorperazine
pIC50 7.89

chlorpromazine
pIC50 7.92

thioridazine
pIC50 8.01

clemastine
pIC50 8.14

chlorprothixene
pKi 8.34

See all 27 drugs...

Ligand (2,379)

prochlorperazine
pKi 8.61

amisulpride
pKi 8.49

CHEMBL418321
pKi 7.00

CHEMBL2037521
pKi 7.00

CHEMBL85
pKi 7.00

CHEMBL3780140
pKi 7.00

CHEMBL1774544
pKi 7.00

CHEMBL3799157
pKi 7.00

CHEMBL240773
pKi 7.00

CHEMBL2367896
pKi 7.00

CHEMBL325060
pKi 7.00

CHEMBL231070
pKi 7.00

CHEMBL42
pKi 7.00

CHEMBL715
pKi 7.00

CHEMBL326454
pKi 7.00

CHEMBL1631532
pKi 7.00

CHEMBL168908
pKi 7.00

CHEMBL1803055
pKi 7.00

CHEMBL595489
pKi 7.00

CHEMBL1173288
pKi 7.00

See all 2379 ligands...

Gene RIF (381)

AA Sequence

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVS      1 - 70
LAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQH     71 - 140
GTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYAR    141 - 210
IYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREE    211 - 280
KTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHV    281 - 350
LNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC                        351 - 400
//

Text Mined References (359)

Summary
Details

	PMID	Year	Title

Tclin D(3) dopamine receptor Add to cart View Collections Empty Collection

Property Summary

Knowledge Summary

Patent (15,034)

TINX Plot

Disease (7)

Expression

Synonym

Gene

PANTHER Protein Class (2)

Ortholog (12)

UniProt Keyword (15)

GO Function (5)

GO Component (5)

GO Process (46)

Compartment GO Term (14)

MGI Phenotype (9)

GWAS Trait (2)

HCA RNA Cell Line (3)

Pathway (26)

PDB (1)

Drug (27)

Ligand (2,379)

Gene RIF (381)

AA Sequence

Text Mined References (359)

Tclin D(3) dopamine receptor

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