Tclin ADRA1B Alpha-1B adrenergic receptor

Protein Summary

Description

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35368
• B0LPE1

Gene Name

• ADRA1B

Ensembl ID

• ENST00000306675
• ENSP00000306662
• ENSG00000170214

Symbol

• ADRA1
• ALPHA1BAR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
ligand (chemical)	0.96
biological process	0.91
gene perturbation	0.89
disease	0.74

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Alpha-1b Adrenergic Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Adrenoceptor / Alpha Adrenoceptor / Alpha-1b Adrenergic Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.3   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 479   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.3   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 638

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 30