Tclin HRH1 Histamine H1 receptor

Protein Summary

Description

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P35367
• A8K047
• Q6P9E5
• H1R

Gene Name

• HRH1

Ensembl ID

• ENST00000397056
• ENSP00000380247
• ENSG00000196639
• ENST00000431010
• ENSP00000397028
• ENST00000438284
• ENSP00000406705

Symbol

• H1R
• H1-R
• HH1R
• hisH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
ligand (chemical)	1
biological process	0.89
virus perturbation	0.88
chemical	0.8

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Histamine H1 Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Histamine Receptor / Histamine H1 Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1437.66   (req: < 5)

Gene RIFs: 82   (req: <= 3)

Antibodies: 508   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1437.66   (req: >= 5)

Gene RIFs: 82   (req: > 3)

Antibodies: 508   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 690

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 95