Property Summary

NCBI Gene PubMed Count 1,912
Grant Count 1,586
R01 Count 928
Funding $180,642,003.93
PubMed Score 12041.64
PubTator Score 7000.88

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Relevance (214)

Disease Z-score Confidence
Cancer 2,346 6.745 3.4
Arthritis 248 5.934 3.0
Familial adenomatous polyposis 31 5.087 2.5
Colitis 46 4.813 2.4
Pain agnosia 99 4.801 2.4
Adenoma 165 4.714 2.4
Cerebrovascular disease 231 4.306 2.2
Coronary artery disease 240 4.25 2.1
Hypertension 287 4.175 2.1
Alzheimer's disease 644 4.165 2.1
Atherosclerosis 275 4.086 2.0
Periodontal disease 37 3.971 2.0
Endometriosis 535 3.962 2.0
Gastritis 44 3.944 2.0
Colorectal adenoma 15 3.926 2.0
Dyspepsia 34 3.914 2.0
Kidney disease 396 3.872 1.9
Barrett's esophagus 183 3.748 1.9
diabetes mellitus 1,663 3.745 1.9
Peptic ulcer disease 11 3.743 1.9
Toxic encephalopathy 131 3.607 1.8
Pleurisy 18 3.596 1.8
Asthma 349 3.586 1.8
Brain disease 83 3.444 1.7
Liver disease 219 3.437 1.7
Diarrhea 155 3.408 1.7
Lung disease 132 3.344 1.7
Dermatitis 107 3.326 1.7
Parkinson's disease 364 3.309 1.7
Ileus 11 3.089 1.5
Obesity 616 3.079 1.5
Colonic benign neoplasm 3 3.076 1.5
Bile reflux 8 3.027 1.5
Cystitis 16 3.011 1.5
Actinic keratosis 22
Acute pain 2
Acute postoperative pain 6
Acute tuberculosis 2
Adenocarcinoma 115
Adenocarcinoma Of Esophagus 14
Adenomatous Polyposis Coli 10
Adhesive capsulitis of shoulder 1
Adrenal Gland Neoplasms 11
Adverse reaction to drug 54
Albuminuria 20
Allergic conjunctivitis 25
Allergic rhinitis 91
Amyotrophic Lateral Sclerosis 431
Ankylosing spondylitis 138
Aortic Aneurysm, Abdominal 10
Arthritic Pain 5
Articular gout 11
Asphyxia neonatorum 9
Asthma, Aspirin-Induced 13
Autistic Disorder 320
B-Cell Lymphomas 5
Backache 8
Barrett Esophagus 16
Bipolar Disorder 266
Bladder Neoplasm 109
Bladder neck obstruction 4
Bone neoplasms 7
Brain Ischemia 87
Breast cancer 3,094
Bursitis 10
Bursitis of shoulder 4
Cachexia 10
Carcinoma, Transitional Cell 31
Cardiac Arrhythmia 20
Cardiomyopathies 90
Cardiovascular Diseases 50
Cerebrovascular accident 44
Cholangiocarcinoma 32
Chronic Lymphocytic Leukemia 242
Chronic pain 9
Chronic ulcerative proctitis 7
Chronic ulcerative rectosigmoiditis 4
Cognition Disorders 23
Colonic Neoplasms 126
Colorectal Neoplasms 217
Common cold 63
Depressive disorder 48
Dermatologic disorders 65
Diabetes Mellitus, Experimental 106
Drug-Induced Liver Injury 118
Duodenal Ulcer due to H. Pylori 7
Duodenal ulcer 20
Dysmenorrhea 19
Edema 38
Esophageal Neoplasms 67
Fever 34
Fibrosis 40
Gastric ulcer 34
Gastroesophageal reflux disease 37
Glaucoma, Open-Angle 4
Glioma 65
Gout 93
Headache disorder 20
Heart failure 80
Hydrolethalus syndrome 128
Hydronephrosis 19
Hyperalgesia 71
Hyperemia 13
Hyperglycemia 120
Hyperplasia 26
Hypertensive disease 193
Indigestion 5
Inflammation 109
Inflammatory Bowel Diseases 87
Influenza-like symptoms 17
Intestinal Polyps 5
Invasive Ductal Breast Carcinoma 9
Joint pain 8
Juvenile rheumatoid arthritis 104
Kidney Diseases 86
Kidney Failure, Chronic 45
Kidney Neoplasm 27
Leiomyosarcoma 19
Leukoplakia, Oral 1
Liver Cirrhosis, Experimental 108
Liver carcinoma 217
Lung Neoplasms 171
Lung diseases 48
Lupus Erythematosus, Systemic 73
Mammary Neoplasms 410
Melanoma 261
Menorrhagia 8
Migraine 79
Mouth Diseases 12
Mouth Neoplasms 42
Muscle pain 3
Myocardial Infarction 126
Nasal discharge 26
Neoplasm Metastasis 138
Neoplasm Recurrence, Local 23
Neurogenic Inflammation 12
Oral Submucous Fibrosis 18
Osteoarthritis 96
Osteoarthritis in Patients at High Ulcer... 7 
Osteoarthrosis of the Knee 4
Pain 70
Pain Treatment Adjunct 3
Pancreatic Neoplasm 79
Pancreatitis 97
Papilloma 27
Patent ductus arteriosus 23
Pericardial effusion 10
Post-Op Ocular Inflammation 10
Post-Op Photophobia 4
Postoperative Ocular Pain 5
Precancerous Conditions 69
Precocious puberty 4
Premature Birth 9
Prevention of Ocular Surgery-Induced Mio... 2 
Prostatic Neoplasms 471
Proteinuria 63
Pulmonary tuberculosis 5
Renal Cell Carcinoma 199
Reperfusion Injury 84
Rheumatism 2
Rheumatoid Arthritis 1,160
Rheumatoid Arthritis in Patient at High ... 7 
Schizophrenia 501 1.0
Seizures 95
Severe pain 12
Shoulder Tendonitis 4
Sinus headache 17
Skin Neoplasms 49
Sprains and Strains 6
Squamous cell carcinoma 94
Squamous cell carcinoma of esophagus 82
Squamous cell carcinoma of the head and ... 24 
Status Epilepticus 85
Stomach Neoplasms 282
Synovitis 38
Tendinitis 13
Tenosynovitis 15
Tension-type headache 10
Thrombosis 42
Thyroid Neoplasm 33
Thyroid associated opthalmopathies 2
Tongue Neoplasms 8
Toothache 6
Ulcerative colitis in remission 4
acute myeloid leukemia 780
adrenocortical adenoma 134
adrenocortical carcinoma 1,427
aldosterone-producing adenoma 664
astrocytoma 1,493
atypical teratoid / rhabdoid tumor 4,369
breast carcinoma 1,614
cystic fibrosis 1,665
glioblastoma 5,572
interstitial cystitis 2,299
intraductal papillary-mucinous adenoma (... 2,956 
lung adenocarcinoma 2,713
lung cancer 4,466
lung carcinoma 2,844
malignant mesothelioma 3,162
medulloblastoma 1,524
medulloblastoma, large-cell 6,234
nasopharyngeal carcinoma 1,056
nervous system disorder 53
non-small cell lung cancer 2,798
oligodendroglioma 2,849
ovarian cancer 8,484
pancreatic cancer 2,300
pediatric high grade glioma 2,712
posterior fossa group B ependymoma 1,530
primitive neuroectodermal tumor 3,031
psoriasis 6,685
remitted schizophrenia patient 3
tuberculosis 1,557
ulcerative colitis 2,087

Expression

  Differential Expression (32)

Disease log2 FC p
malignant mesothelioma -7.800 0.000
remitted schizophrenia patient 1.100 0.045
oligodendroglioma -2.100 0.039
astrocytoma -1.400 0.000
glioblastoma -3.100 0.001
medulloblastoma -3.200 0.000
cystic fibrosis 3.051 0.000
atypical teratoid / rhabdoid tumor -3.300 0.000
medulloblastoma, large-cell -3.600 0.008
primitive neuroectodermal tumor -3.700 0.001
adrenocortical adenoma -1.952 0.000
adrenocortical carcinoma -1.943 0.006
tuberculosis -2.600 0.000
non-small cell lung cancer -1.830 0.000
intraductal papillary-mucinous adenoma (... -1.600 0.011
Hydrolethalus syndrome 2.229 0.021
lung cancer -1.800 0.000
pancreatic cancer 1.900 0.001
interstitial cystitis 2.800 0.007
pediatric high grade glioma -2.100 0.019
posterior fossa group B ependymoma -1.800 0.016
aldosterone-producing adenoma -1.469 0.018
nasopharyngeal carcinoma 3.100 0.000
lung adenocarcinoma -1.841 0.006
psoriasis -1.300 0.000
Breast cancer -3.000 0.000
lung carcinoma -3.400 0.000
breast carcinoma -1.600 0.000
Bipolar Disorder 2.371 0.039
acute myeloid leukemia 2.800 0.008
ulcerative colitis 5.200 0.000
ovarian cancer 1.800 0.019

Synonym

Accession P35354 A8K802 Q16876
Symbols COX2
COX-2
PHS-2
PGG/HS
PGHS-2
hCox-2
GRIPGHS

Gene

PANTHER Protein Class (2)

PDB

1V0X   5F19   5F1A   5IKQ   5IKR   5IKT   5IKV