Tclin ADRA1A Alpha-1A adrenergic receptor

Protein Summary

Description

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35348
• A8K0I3
• B0ZBD1
• B0ZBD2
• B0ZBD4
• B0ZBD5
• B0ZBD6
• B0ZBD8
• B0ZBD9
• O60451
• Q13675
• Q13729
• Q4VBM7
• Q6RUJ4
• Q6RUJ5
• Q6RUJ7
• Q6RUJ8
• Q6RUJ9
• Q96RE8
• Q9UD63
• Q9UD67

Gene Name

• ADRA1A

Ensembl ID

• ENST00000276393
• ENSP00000276393
• ENSG00000120907
• ENST00000354550
• ENSP00000346557
• ENST00000380572
• ENSP00000369946
• ENST00000380573
• ENSP00000369947
• ENST00000380582
• ENSP00000369956
• ENST00000380586
• ENSP00000369960
• ENST00000519096
• ENSP00000431073
• ENST00000521711
• ENSP00000430414

Symbol

• ADRA1C
• ADRA1C
• ADRA1L1
• ALPHA1AAR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
ligand (chemical)	0.99
biological process	0.97
chemical	0.85
disease	0.72

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Alpha-1a Adrenergic Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Adrenoceptor / Alpha Adrenoceptor / Alpha-1a Adrenergic Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.08   (req: < 5)

Gene RIFs: 84   (req: <= 3)

Antibodies: 336   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.08   (req: >= 5)

Gene RIFs: 84   (req: > 3)

Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1202

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 43