Property Summary

NCBI Gene PubMed Count 111
PubMed Score 150.42
PubTator Score 199.68

Knowledge Summary

Patent (4,961)


  Disease Sources (4)

Disease Target Count
Acute exacerbation of asthma 14
Administration of Local Anesthetic Nerve Block 14
Allergic Reactions 7
Allergic conjunctivitis 25
Allergic rhinitis 92
Asthma 349
Asthma management 20
Benign prostatic hyperplasia 7
Bronchiectasis 29
Bronchitis 44
Cerebral ischemia 12
Cerebrovascular disease 231
Common cold 63
Cough 21
Dermal Necrosis 6
Diagnostic Test for Pheochromocytoma 6
Dilated pupil 6
Disorder of blood vessel 4
Dyspnea 8
Essential Hypertension 82
Exacerbation of asthma 11
Fever 34
Headache disorder 20
Hemorrhoids 13
Hypertension Secondary to Pheochromocytoma 6
Hypertensive Emergencies 10
Hypertensive disorder 58
Hypertensive emergency 3
Hypotension Secondary to Spinal Anesthesia 2
Influenza-like symptoms 17
Local anesthesia 40
Local anesthesia, by infiltration 14
Low blood pressure 9
Nasal congestion 24
Nasal discharge 26
Open-angle glaucoma 26
Orthostatic hypotension 9
Parkinson's disease 364
Paroxysmal hypertension 6
Paroxysmal supraventricular tachycardia 11
Peripheral vascular disease 90
Persistent erythema of skin 2
Persistent pulmonary hypertension of the newborn 8
Pheochromocytoma 22
Prevention of Hypertension in Pheochromocytoma 6
Prevention of Hypotension During Spinal Anesthesia 2
Prevention of Posterior Synechiae 4
Proctitis 11
Pruritus ani 14
Pulmonary emphysema 34
Rectal pain 3
Red eye 7
Reverse Mydriasis from Ophthalmic Adrenergic or Anticholinergic Agent 2
Rhinitis 46
Seasonal allergic rhinitis 10
Sinus headache 17
Sneezing 11
Vasomotor rhinitis 15
Wheezing 7
anaphylaxis 11
Disease Target Count P-value
psoriasis 6685 9.68846766726901E-68
lung cancer 4473 0.0229143541999808


  Differential Expression (2)

Disease log2 FC p
lung cancer -1.200 0.023
psoriasis -2.100 0.000


PANTHER Protein Class (2)

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Anole lizard OMA EggNOG
Xenopus OMA EggNOG

  TechDev Info (1)

MLP Assay (2)

AID Type Active / Inconclusive / Inactive Description
434974 screening 0 / 0 / 0 Late-stage radioligand binding assay to identify inhibitors of NADPH oxidase 1 (NOX1): PDSP screen
504381 other 0 / 0 / 0 Late-stage radioligand binding assay to identify inhibitors of NADPH oxidase 1 (NOX1): PDSP screen Set 2

Gene RIF (92)

25913761 alpha1A-adrenoceptor subtypes predominantly contributed to human IAS contraction
25775528 heteromeric receptor complexes between alpha1A-AR and CXCR4 and between alpha1B-AR and CXCR4 are constitutively expressed in rat and human vascular smooth muscle cells; the quaternary structure of the receptor complex is important for signaling and contraction
25606852 Data are presented that indicate that Iso represents a novel type of alpha1A-AR partial agonist with signaling bias toward MAPK/ERK signaling cascade that is likely independent of coupling to Galphaq.
25425303 The alpha-AR-induced mydriasis in mice is mediated mainly by the alphaA-AR, with a smaller contribution of the alphaB-AR, matching the relative abundance of these subtypes at the mRNA level.
24844469 alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1, IGF-1, hyaluronan and PIP production in human skin fibroblasts.
24835978 The ADRA1A mutant triggers two distinct EGFR transactivation-dependent signaling pathways: 1) constitutive Gq-independent beta-arrestin-1/Src/MMP/EGFR/ERK-dependent hyperproliferation and 2) agonist-induced Gq- and EGFR/STAT-dependent hypertrophy.
24548768 Data suggested ADRA1A Arg347Cys polymorphism as susceptibility factor in patients with vasovagal syncope; ArgArg genotype could be a marker for vasovagal syncope susceptibility in the Mexican population
24342464 alpha1-AR expression is greater on nerve fibers in skin affected by complex regional pain syndrome type II (CRPS) than in unaffected skin from the same patient or from pain-free controls.
23902938 Adrenergic alpha1A receptor subtypes transactivate epidermal growth factor receptors.
23877383 Mean alpha-receptor stain rates in renal pelvis were 2.65 +/- 0.74, 1.35 +/- 0.81 and 2.9 +/- 0.30 for alpha 1A, 1B and 1D, respectively. For calyces, the rates are 2.40 +/- 0.82, 1.50 +/- 0.76 and 2.75 +/- 0.44 for alpha 1A, 1B and 1D, respectively.

AA Sequence


Text Mined References (116)

PMID Year Title
25913761 2015 Characterizations of the ?1-adrenoceptor subtypes mediating contractions of the human internal anal sphincter.
25775528 2015 Heteromerization of chemokine (C-X-C motif) receptor 4 with ?1A/B-adrenergic receptors controls ?1-adrenergic receptor function.
25606852 2015 Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.
25425303 2014 Role of ??-adrenoceptor subtypes in pupil dilation studied with gene-targeted mice.
24844469 2014 The stimulatory effects of alpha1-adrenergic receptors on TGF-beta1, IGF-1 and hyaluronan production in human skin fibroblasts.
24835978 2014 Alpha1a-adrenoceptor genetic variant induces cardiomyoblast-to-fibroblast-like cell transition via distinct signaling pathways.
24816252 2014 An atlas of genetic influences on human blood metabolites.
24548768 2014 Arg347Cys polymorphism of ?1a-adrenergic receptor in vasovagal syncope. Case-control study in a Mexican population.
24342464 2014 Upregulation of ?1-adrenoceptors on cutaneous nerve fibres after partial sciatic nerve ligation and in complex regional pain syndrome type II.
23902938 2013 Intracellular transactivation of epidermal growth factor receptor by ?1A-adrenoceptor is mediated by phosphatidylinositol 3-kinase independently of activation of extracellular signal regulated kinases 1/2 and serine-threonine kinases in Chinese hamster ovary cells.