Tclin SSTR5 Somatostatin receptor type 5

Protein Summary

Description

Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• P35346
• P34988
• Q541E0
• Q9UJI5
• SS-5-R

Gene Name

• SSTR5

Ensembl ID

• ENST00000293897
• ENSP00000293897
• ENSG00000162009

Symbol

• SS-5-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.97
co-expressed gene	0.93
biological process	0.67
protein domain	0.58
molecular function	0.56

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Somatostatin Receptor Type 5

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Somatostatin Receptor Type 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.99   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 275   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.99   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 332

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4