Tdark | Small proline-rich protein 2B |
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
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PMID | Text |
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22374195 | An SNP in SPRR2B was predictive of asthma among white children with eczema from 2 independent populations. |
21985131 | We showed that just four genes, G3BP2, SCARB2, CSNK1A1 and SPRR2B, can classify patients as presence of lymph node metastasis negative or positive, with 80.0% accuracy. |
18643845 | Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. |
14748073 | SPR2B transcripts and protein were moderately increased in the human papillomaviurs 11- and 59-infected tissues. |
PMID | Year | Title |
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22374195 | 2012 | Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema. |
21985131 | 2012 | Four-gene expression model predictive of lymph node metastases in oral squamous cell carcinoma. |
18643845 | 2009 | Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. |
16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. |
16639001 | 2006 | Expression and regulation of cornified envelope proteins in human corneal epithelium. |
15232223 | 2004 | Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus. |
14748073 | 2004 | Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3. |
11279051 | 2001 | Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. |
9722562 | 1998 | Structural and transglutaminase substrate properties of the small proline-rich 2 family of cornified cell envelope proteins. |
8325635 | 1993 | Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. |
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