Property Summary

NCBI Gene PubMed Count 306
PubMed Score 1832.47
PubTator Score 1077.73

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
psoriasis 6685 4.85692499137797E-7
juvenile dermatomyositis 1189 1.0221616127836E-6
acute quadriplegic myopathy 1157 1.17842946955392E-6
pituitary cancer 1972 8.46083317818832E-6
breast carcinoma 1614 9.86106762563315E-6
posterior fossa group A ependymoma 1511 1.4139271207538E-4
tuberculosis and treatment for 3 months 327 1.83376925709807E-4
dermatomyositis 967 4.71594224994985E-4
lung cancer 4473 8.43286139351367E-4
hepatocellular carcinoma 550 0.0011406746451936
interstitial cystitis 2299 0.0014437042021678
fibroadenoma 557 0.00175944816585897
ductal carcinoma in situ 1745 0.00181587275449649
gastric cancer 436 0.0019575508215974
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00256930408946476
active ulcerative colitis 477 0.00327187367256492
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00360553343441546
Multiple Sclerosis 498 0.0038112737657412
Multiple myeloma 1328 0.00427035211866646
Rheumatoid Arthritis 1171 0.00664467858368843
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0086624819824724
atypical teratoid / rhabdoid tumor 4369 0.00972562248678938
glioblastoma 5572 0.0105690292983922
invasive ductal carcinoma 2950 0.011014319217816
pediatric high grade glioma 2712 0.0134250285154757
group 4 medulloblastoma 1875 0.0362156140067461
medulloblastoma, large-cell 6234 0.037339040650539
active Crohn's disease 918 0.0416383542988843
pancreatic cancer 2300 0.0422298652486597
Disease Target Count Z-score Confidence
Essential Hypertension 82 0.0 2.0



Accession P35318 B2R793 D3DQV3 Q6FGW2
Symbols AM



PANTHER Protein Class (2)


2FLY   2L7S   4RWF  

  Ortholog (10)

 GO Function (1)

Gene RIF (265)

26762744 High Adrenomedullin expression is associated with Malignant Pleural Mesothelioma.
26662217 conclusion supplementation with selenium and coenzyme Q10 during four years resulted in less concentration of both copeptin and MR-proADM
26597206 In addition to its role in the complement system, complement factor H has an another role, as a binding protein for the regulatory peptide adrenomedullin. (Review)
26461449 Higher levels of Proadrenomedullin are associated with Primary Graft Dysfunction and Mortality Following Lung Transplantation.
26342564 we found significantly lower plasma MR-proADM levels in patients with elevated anxiety scores
26286191 Proadrenomedullin was increased in complicated vs. uncomplicated community acquired pediatric pneumonia.
26271020 Among adrenomedullin, CRP, and PCT, procalcitonin demonstrates the highest correlation with the severity of infection.
26196743 tested the hypothesis that AM-deficient fetal primary pulmonary microvascular endothelial cells (HPMEC) will have increased oxidative stress, inflammation, and cytotoxicity compared to AM-sufficient HPMEC upon exposure to hyperoxia
26043778 Results suggest that ADM plays an important role in intrahepatic cholangiocellular carcinoma metastasis, and that ADM signaling of epithelial-mesenchymal transition may represent a valuable therapeutic target in cancer patients.
26035796 targeting of the ADM/ADM acceptors/ERK1/2/Bcl-2 pathway may provide a potential strategy through which to induce the apoptosis of osteosarcoma cells.

AA Sequence


Text Mined References (308)

PMID Year Title
26762744 2016 Functional Analysis of the Adrenomedullin Pathway in Malignant Pleural Mesothelioma.
26662217 Less increase of copeptin and MR-proADM due to intervention with selenium and coenzyme Q10 combined: Results from a 4-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.
26597206 2015 Complement factor H in its alternative identity as adrenomedullin-binding protein 1.
26461449 2016 Primary Graft Dysfunction and Mortality Following Lung Transplantation: A Role for Proadrenomedullin Plasma Levels.
26342564 2015 Plasma mid-regional pro-adrenomedullin levels are inversely associated with anxiety but unrelated to depression: Results from the observational DIAST-CHF study in patients with cardiovascular risk factors.
26286191 2015 Proadrenomedullin and copeptin in pediatric pneumonia: a prospective diagnostic accuracy study.
26271020 2015 Adrenomedullin--A New Marker in Febrile Neutropenia: Comparison With CRP and Procalcitonin.
26196743 2015 Adrenomedullin deficiency potentiates hyperoxic injury in fetal human pulmonary microvascular endothelial cells.
26043778 2015 Adrenomedullin promotes intrahepatic cholangiocellular carcinoma metastasis and invasion by inducing epithelial-mesenchymal transition.
26035796 2015 Hypoxia-induced apoptosis is blocked by adrenomedullin via upregulation of Bcl-2 in human osteosarcoma cells.