Property Summary

NCBI Gene PubMed Count 166
Grant Count 111
R01 Count 77
Funding $13,907,627.86
PubMed Score 467.03
PubTator Score 303.08

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (6)

Disease log2 FC p
Multiple myeloma 1.220 0.000
psoriasis 1.200 0.000
lung cancer 2.000 0.000
nasopharyngeal carcinoma 1.100 0.002
lung adenocarcinoma 1.115 0.000
ovarian cancer 2.200 0.000

Synonym

Accession P35232 B4DY47 Q4VBQ0
Symbols PHB1
HEL-215
HEL-S-54e

Gene

PHB

PDB

1LU7  

Gene RIF (132)

PMID Text
26496733 The present review focus is on recent developments in prohibitin (PHB) research in relation to ovarian granulosa cells physiological functions. [review]
26064897 We propose a model whereby in analogy to previous findings (e.g., the RAS-RAF signalling pathway), PHB can act as a signalling scaffold protein to assist in KDELR-dependent Src activation
25932630 a majority of patients with IgG4-related disease have antibodies against prohibitin.
25777779 miR-27a was shown to be a significant tumor suppressor by targeting and decreasing PHB protein expression in glioma U251 cells. miR-27a targeting of PHB may be a novel potential therapeutic strategy for glioma
25575814 PHB phosphorylated at threonine 258 and MIG-7 may play complementary roles in the initiation and sustainment of the effects of growth factors and COX-2/PGE2 on cancer invasion/metastasis.
25444511 Knockdown of prohibitin expression promotes glucose metabolism in eutopic endometrial stromal cells from women with endometriosis.
25344214 we have provided a modified method for isolating and identifying membrane proteins and demonstrated that PHB1 may be a promising biomarker for early diagnosis and therapy of pancreatic (and potentially other) cancers.
24975845 A protective role of PHB that is dependent on pS727-Stat3 to prevent mitochondrial dysfunction in intestinal epithelial cells.
24966933 The study suggest that the tumor suppressing action of prohibitin is probably associated with luteinizing hormone mediated protection role against ovarian epithelial carcinoma.
24879411 The T allele of the rs6917 polymorphism was associated with reduced PHB mRNA levels.
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AA Sequence

MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCR      1 - 70
SRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELI     71 - 140
TQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAA    141 - 210
IISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ            211 - 272
//

Text Mined References (172)

PMID Year Title
26496733 2016 Prohibitin( PHB) roles in granulosa cell physiology.
26310625 2015 F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy.
26064897 2015 Prohibitin: A Novel Molecular Player in KDEL Receptor Signalling.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25932630 2015 Prohibitin Is Involved in Patients with IgG4 Related Disease.
25777779 2015 Emerging role of microRNA-27a in human malignant glioma cell survival via targeting of prohibitin.
25575814 2015 MIG-7 and phosphorylated prohibitin coordinately regulate lung cancer invasion/metastasis.
25444511 2014 Knockdown of prohibitin expression promotes glucose metabolism in eutopic endometrial stromal cells from women with endometriosis.
25344214 2015 Identification of prohibitin 1 as a potential prognostic biomarker in human pancreatic carcinoma using modified aqueous two-phase partition system combined with 2D-MALDI-TOF-TOF-MS/MS.
24975845 2014 Prohibitin 1 modulates mitochondrial function of Stat3.
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