HTR7
5-hydroxytryptamine receptor 7
Protein Summary
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
- ENST00000277874
- ENSP00000277874
- ENSG00000148680
- ENST00000336152
- ENSP00000337949
- ENST00000371719
- ENSP00000360784
- 5-HT7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
ligand (chemical) | 1 | ||
drug | 0.89 | ||
disease perturbation | 0.83 | ||
histone modification site profile | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 113.87 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 385 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 113.87 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 385 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1339
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 32