Tchem EPHX2 Bifunctional epoxide hydrolase 2

Protein Summary

Description

Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12869654, PubMed:12574510, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12869654, PubMed:12574510, PubMed:22798687). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510). This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• P34913
• B2Z3B1
• B3KTU8
• B3KUA0
• G3V134
• J3KPH7
• Q16764
• Q9HBJ1
• Q9HBJ2

Gene Name

• EPHX2

Ensembl ID

• ENST00000380476
• ENSP00000369843
• ENSG00000120915
• ENST00000521400
• ENSP00000430269
• ENST00000521780
• ENSP00000430302

Symbol

• CEH
• SEH
• ABHD20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.97
transcription factor perturbation	0.96
gene perturbation	0.95
protein domain	0.92
chemical	0.81

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Bifunctional Epoxide Hydrolase 2

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Bifunctional Epoxide Hydrolase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.85   (req: < 5)

Gene RIFs: 88   (req: <= 3)

Antibodies: 368   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.85   (req: >= 5)

Gene RIFs: 88   (req: > 3)

Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1744

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6