Protein Summary
Target-derived survival factor for peripheral sensory sympathetic neurons. This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]
- ENST00000593537
- ENSP00000469455
- ENSG00000225950
- NTF5
- NT4
- NT5
- NT-4
- NT-5
- NTF5
- GLC10
- GLC1O
- NT-4/5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.73 | ||
virus perturbation | 0.64 | ||
biological process | 0.6 | ||
cellular component | 0.53 | ||
disease | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 535.55 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 584 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 535.55 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 584 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0