Tclin GUCY1A2 Guanylate cyclase soluble subunit alpha-2

Protein Summary

Description

Has guanylyl cyclase on binding to the beta-1 subunit. Isoform 2 acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits. Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• P33402
• A1L4C4
• B7ZLT5
• GCS-alpha-2

Gene Name

• GUCY1A2

Ensembl ID

• ENST00000282249
• ENSP00000282249
• ENSG00000152402
• ENST00000347596
• ENSP00000344874
• ENST00000526355
• ENSP00000431245

Symbol

• GUC1A2
• GUCSA2
• GC-SA2
• GUC1A2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
trait	0.86
protein domain	0.85
gene perturbation	0.73
biological process	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.87   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.87   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5