Property Summary

NCBI Gene PubMed Count 71
PubMed Score 188.21
PubTator Score 107.52

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (4)

Disease Target Count P-value
medulloblastoma, large-cell 6234 1.3743007064506E-5
atypical teratoid / rhabdoid tumor 4369 3.30947176274585E-5
osteosarcoma 7933 6.36557997576593E-5
ovarian cancer 8492 2.18528894646336E-4
glioblastoma 5572 2.44314997911448E-4
psoriasis 6685 2.76608053521503E-4
primitive neuroectodermal tumor 3031 3.33464204780975E-4
group 4 medulloblastoma 1875 7.82891521898591E-4
astrocytoma 1493 0.00273903391586518
dermatomyositis 967 0.00347578768455846
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00375095917338138
ulcerative colitis 2087 0.00544888048545526
cutaneous lupus erythematosus 1056 0.00809355817294794
Down syndrome 548 0.0100609346006571
progressive supranuclear palsy 674 0.0115985693268158
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0155399666556816
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
lung cancer 4473 4.576 2.3
Adenocarcinoma 115 3.903 2.0
Blackwater fever 2 3.832 1.9

Expression

Synonym

Accession P33176 A0AVB2 Q5VZ85
Symbols KNS
KINH
KNS1
UKHC
HEL-S-61

Gene

PDB

1BG2   1MKJ   2P4N   3J8X   3J8Y   4HNA   4LNU  

  Ortholog (16)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Pig OMA Inparanoid
Opossum OMA Inparanoid
Platypus OMA Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid
C. elegans OMA Inparanoid
Fruitfly OMA Inparanoid

Gene RIF (49)

PMID Text
26991731 Data suggest that light-chain subunits/fragments of kinesin-1 inhibit the pathological aggregation of amyloid(beta).
26627252 differences between the structural kinetics of Eg5 and kinesin-1 yield insights into how these two motors adapt their enzymologies for their distinct functions
26598607 KIF5B is essential for Ostm1 intracellular dispersion.
26268359 data suggest one-step screening platform for KIF5B-RET as well as EGFR, K-RAS, ALK oncogenic mutations be necessary for lung adenocarcinoma patients
25902401 Kinesin-1 is primarily front-head gated, and its neck linker length is tuned to enhance unidirectional processivity and velocity.
25818289 the front head of a kinesin dimer is gated by the backward orientation of its neck linker until the rear head releases from the microtubule
25676575 In this work, we performed normal mode analysis with elastic network model using different conformation of kinesin to determine the effect of tail binding.
25660542 Myo1c significantly increases the frequency of kinesin-1-driven microtubule-based runs that begin at actin/microtubule intersections. The actin-binding protein tropomyosin 2 abolishes Myo1c-specific effects on both run initiation and run termination.
25537000 This study has provided a comprehensive structural and dynamic picture of kinesin's major ATPase states.
25516977 nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.
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AA Sequence

MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIV      1 - 70
KDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLD     71 - 140
KIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLI    141 - 210
NVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDS    211 - 280
KMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEK    281 - 350
NKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRK    351 - 420
CEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKE    421 - 490
VLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLK    491 - 560
DLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELA    561 - 630
ACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQA    631 - 700
VEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTV    701 - 770
MQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLE    771 - 840
QLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKN    841 - 910
MARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAVRGGGGKQV                     911 - 963
//

Text Mined References (83)

PMID Year Title
26991731 2016 Kinesin-1 inhibits the aggregation of amyloid-? peptide as detected by fluorescence cross-correlation spectroscopy.
26627252 2015 The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5.
26598607 2015 Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.
26268359 2015 KIF5B-RET Fusion gene may coincide oncogenic mutations of EGFR or KRAS gene in lung adenocarcinomas.
25902401 2015 Examining kinesin processivity within a general gating framework.
25818289 2015 Kinesin's front head is gated by the backward orientation of its neck linker.
25676575 2015 Identification of tail binding effect of kinesin-1 using an elastic network model.
25660542 2015 Control of the initiation and termination of kinesin-1-driven transport by myosin-Ic and nonmuscle tropomyosin.
25537000 2015 Decrypting the structural, dynamic, and energetic basis of a monomeric kinesin interacting with a tubulin dimer in three ATPase states by all-atom molecular dynamics simulation.
25516977 2015 Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.
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