Property Summary

NCBI Gene PubMed Count 71
Grant Count 45
R01 Count 29
Funding $4,728,755.12
PubMed Score 188.21
PubTator Score 107.52

Knowledge Summary

Patent

No data available

Expression

Gene RIF (49)

PMID Text
26991731 Data suggest that light-chain subunits/fragments of kinesin-1 inhibit the pathological aggregation of amyloid(beta).
26627252 differences between the structural kinetics of Eg5 and kinesin-1 yield insights into how these two motors adapt their enzymologies for their distinct functions
26598607 KIF5B is essential for Ostm1 intracellular dispersion.
26268359 data suggest one-step screening platform for KIF5B-RET as well as EGFR, K-RAS, ALK oncogenic mutations be necessary for lung adenocarcinoma patients
25902401 Kinesin-1 is primarily front-head gated, and its neck linker length is tuned to enhance unidirectional processivity and velocity.
25818289 the front head of a kinesin dimer is gated by the backward orientation of its neck linker until the rear head releases from the microtubule
25676575 In this work, we performed normal mode analysis with elastic network model using different conformation of kinesin to determine the effect of tail binding.
25660542 Myo1c significantly increases the frequency of kinesin-1-driven microtubule-based runs that begin at actin/microtubule intersections. The actin-binding protein tropomyosin 2 abolishes Myo1c-specific effects on both run initiation and run termination.
25537000 This study has provided a comprehensive structural and dynamic picture of kinesin's major ATPase states.
25516977 nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.
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AA Sequence

MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIV      1 - 70
KDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLD     71 - 140
KIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLI    141 - 210
NVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDS    211 - 280
KMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEK    281 - 350
NKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRK    351 - 420
CEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKE    421 - 490
VLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLK    491 - 560
DLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELA    561 - 630
ACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQA    631 - 700
VEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTV    701 - 770
MQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLE    771 - 840
QLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKN    841 - 910
MARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAVRGGGGKQV                     911 - 963
//

Text Mined References (83)

PMID Year Title
26991731 2016 Kinesin-1 inhibits the aggregation of amyloid-? peptide as detected by fluorescence cross-correlation spectroscopy.
26627252 2015 The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5.
26598607 2015 Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.
26268359 2015 KIF5B-RET Fusion gene may coincide oncogenic mutations of EGFR or KRAS gene in lung adenocarcinomas.
25902401 2015 Examining kinesin processivity within a general gating framework.
25818289 2015 Kinesin's front head is gated by the backward orientation of its neck linker.
25676575 2015 Identification of tail binding effect of kinesin-1 using an elastic network model.
25660542 2015 Control of the initiation and termination of kinesin-1-driven transport by myosin-Ic and nonmuscle tropomyosin.
25537000 2015 Decrypting the structural, dynamic, and energetic basis of a monomeric kinesin interacting with a tubulin dimer in three ATPase states by all-atom molecular dynamics simulation.
25516977 2015 Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.
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