Protein Summary
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]
- ENST00000324750
- ENSP00000318077
- ENSG00000176136
- ENST00000589410
- ENSP00000468086
- MC2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
protein domain | 0.73 | ||
ligand (protein) | 0.68 | ||
disease perturbation | 0.56 | ||
cell type or tissue | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 111.52 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 384 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 111.52 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 384 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 105
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2