Property Summary

NCBI Gene PubMed Count 52
Grant Count 106
R01 Count 37
Funding $13,886,462.02
PubMed Score 52.58
PubTator Score 76.99

Knowledge Summary

Patent (4,474)

Expression

  Differential Expression (4)

Disease log2 FC p
osteosarcoma -1.844 0.000
atypical teratoid / rhabdoid tumor -1.200 0.000
group 3 medulloblastoma 1.500 0.001
pituitary cancer -1.500 0.000

Synonym

Accession P32298 O00641 O00642 Q13293 Q13294 Q13295 Q14453 Q14725 Q15313 Q15314 Q15315 Q15316 Q17RH6 Q53EQ8
Symbols IT11
GPRK4
GRK4a
GPRK2L

Gene

PDB

4YHJ  

 MGI Term (1)

Gene RIF (45)

PMID Text
26820533 Thus, we provided new insight into the function of GRKs in agonist-unstimulated GPCR trafficking using a recombinant AM1 receptor and further determined the region of the CLR C-tail responsible for this GRK function.
26730182 Subgroup analysis for ethnicity showed that rs1024323 locus of GRK4 gene was associated with hypertension in Caucasians (OR =1.826, 95% CI =1.215-2.745, P=0.004) but not in East Asians and Africans. [meta-analysis]
26667412 hGRK4gamma(142V) phosphorylates histone deacetylase type 1 and promotes its nuclear export to the cytoplasm, resulting in increased AT1R expression and greater pressor response to angiotensin II.
26250109 The C-terminal region of FMRP interacts with a domain of GRK4 mRNA that is folded in four stem loops.
26134571 GRK4alpha is more similar to GRK2 than GRK6. A fully ordered kinase C-tail reveals interactions linking the C-tail with important determinants of kinase activity, including the alphaB helix, alphaD helix, and the P-loop
25870190 GRK4 genetic polymorphism plays an important role in the regulation of hypertension.
25768006 A high sodium intake markedly increased the obesity risk in variants of GRK4 A486V regardless of sex amongst Korean children.
25732908 the association between GRK4(142V) and a larger decrease in blood pressure with angiotensin receptor blockers in hypertensive patients.
25023003 Mutations in GRK4 gene is associated with stress fracture.
24218433 This study provides a mechanism by which GRK4, via regulation of arterial AT(1)R expression and function, participates in the pathogenesis of conduit vessel abnormalities in hypertension.
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AA Sequence

MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPIGRRLFRQF      1 - 70
CDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSK     71 - 140
KAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATG    141 - 210
KMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLG    211 - 280
NPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTV    281 - 350
GYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI    351 - 420
CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGI    421 - 490
YLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRR    491 - 560
GGCLTMVPSEKEVEPKQC                                                        561 - 578
//

Text Mined References (55)

PMID Year Title
26820533 2016 Inhibitory effects of two G protein-coupled receptor kinases on the cell surface expression and signaling of the human adrenomedullin receptor.
26730182 2016 Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis.
26667412 2016 Human GRK4?142V Variant Promotes Angiotensin II Type I Receptor-Mediated Hypertension via Renal Histone Deacetylase Type 1 Inhibition.
26250109 2015 The FMRP/GRK4 mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum.
26134571 2015 Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.
25870190 2015 G protein-coupled receptor kinase 4: role in hypertension.
25768006 2015 Gender-based differences on the association between salt-sensitive genes and obesity in Korean children aged between 8 and 9 years.
25732908 2016 Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade.
25023003 2014 Novel candidate genes putatively involved in stress fracture predisposition detected by whole-exome sequencing.
24218433 2014 Role of GRK4 in the regulation of arterial AT1 receptor in hypertension.
More...