Tchem CCR1 C-C chemokine receptor type 1

Protein Summary

Description

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P32246
• Q86VA9
• C-C CKR-1

Gene Name

• CCR1

Ensembl ID

• ENST00000296140
• ENSP00000296140
• ENSG00000163823

Symbol

• CMKBR1
• CMKR1
• SCYAR1
• CKR1
• CD191
• CKR-1
• HM145
• CMKBR1
• MIP1aR
• SCYAR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein)	1
biological process	0.93
molecular function	0.91
biological term	0.72
phenotype	0.65

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Chemokine Receptor / C-c Chemokine Receptor / C-c Chemokine Receptor Type 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 474.8   (req: < 5)

Gene RIFs: 97   (req: <= 3)

Antibodies: 480   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 474.8   (req: >= 5)

Gene RIFs: 97   (req: > 3)

Antibodies: 480   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 400

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1