Tclin CCKBR Gastrin/cholecystokinin type B receptor

Protein Summary

Description

Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism. This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• P32239
• A8K7P9
• O75824
• Q16144
• Q92492
• Q96LC6
• Q9NYK7
• Q9UBV1
• CCK-B receptor

Gene Name

• CCKBR

Ensembl ID

• ENST00000334619
• ENSP00000335544
• ENSG00000110148
• ENST00000525462
• ENSP00000435534

Symbol

• CCKRB
• GASR
• CCK-B
• CCK2R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.97
molecular function	0.95
gene perturbation	0.78
phenotype	0.76
disease	0.71

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Gastrin/cholecystokinin Type B Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Cholecystokinin Receptor / Gastrin/cholecystokinin Type B Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 616.57   (req: < 5)

Gene RIFs: 80   (req: <= 3)

Antibodies: 325   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 616.57   (req: >= 5)

Gene RIFs: 80   (req: > 3)

Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 656

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1