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  5. Cholecystokinin receptor
  6. Cholecystokinin receptor type A

Tclin Cholecystokinin receptor type A

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

Ligand Count 220
NCBI Gene PubMed Count 84
PubMed Score 539.13
PubTator Score 256.25

Knowledge Summary

Patent (16,627)

TINX Plot

  Disease (6)

Disease Target Count Z-score Confidence
Alcoholism 45 0.0 0.0
Gallbladder Neoplasms 10 0.0 0.0
Disease Target Count
Diagnostic aid 1
Disease Target Count P-value
psoriasis 6694 3.3e-10
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8

Expression

  Differential Expression (1)

Disease log2 FC p
psoriasis -2.300 3.3e-10

Synonym

Accession P32238 B2R9Z5 CCK-A receptor
Symbols CCK-A
CCK1R
CCKRA
CCK1-R

Gene

CCKAR

PANTHER Protein Class (2)

  Ortholog (10)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG

 UniProt Keyword (14)

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 GO Function (2)

 GO Component (2)

 GO Process (13)

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 Compartment GO Term (16)

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 MGI Phenotype (12)

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 GWAS Trait (1)

 HCA RNA Cell Line (8)

Pathway (13)

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Protein-protein Interaction (1)

CCK  

PDB (3)

Drug (1)

Structure of ceruletide

ceruletide

Ligand (219)

Structure of CHEMBL302150

CHEMBL302150
pIC50 7.00

Structure of CHEMBL303635

CHEMBL303635
pIC50 7.00

Structure of CHEMBL345786

CHEMBL345786
pIC50 7.00

Structure of CHEMBL566360

CHEMBL566360
pKi 7.00

Structure of CHEMBL584525

CHEMBL584525
pKi 7.00

Structure of CHEMBL1774040

CHEMBL1774040
pIC50 7.02

Structure of CHEMBL1269258

CHEMBL1269258
pIC50 7.03

Structure of CHEMBL2017829

CHEMBL2017829
pIC50 7.03

Structure of CHEMBL91986

CHEMBL91986
pIC50 7.05

Structure of CHEMBL88545

CHEMBL88545
pIC50 7.06

Structure of CHEMBL2017834

CHEMBL2017834
pIC50 7.06

Structure of CHEMBL2017826

CHEMBL2017826
pIC50 7.10

Structure of CHEMBL570163

CHEMBL570163
pKi 7.10

Structure of CHEMBL108130

CHEMBL108130
pIC50 7.10

Structure of CHEMBL584063

CHEMBL584063
pKi 7.10

Structure of CHEMBL570521

CHEMBL570521
pKi 7.10

Structure of CHEMBL320141

CHEMBL320141
pKi 7.10

Structure of CHEMBL95200

CHEMBL95200
pKi 7.10

Structure of CHEMBL566359

CHEMBL566359
pKi 7.10

Structure of CHEMBL88239

CHEMBL88239
pIC50 7.12

Gene RIF (71)

AA Sequence 

MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNK      1 - 70
RMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERY     71 - 140
GAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWH    141 - 210
TFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKL    211 - 280
ELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGT    281 - 350
PISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH    351 - 420
MSASVPPQ                                                                  421 - 428
//

Text Mined References (85)

PMID Year Title