| Tclin | Cholecystokinin receptor type A |
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| NCBI Gene PubMed Count | 81 |
| Grant Count | 131 |
| R01 Count | 102 |
| Funding | $15,567,343.97 |
| PubMed Score | 532.00 |
| PubTator Score | 256.25 |
CHEMBL302150
pIC50 7.00
CHEMBL303635
pIC50 7.00
CHEMBL345786
pIC50 7.00
CHEMBL566360
pKi 7.00
CHEMBL584525
pKi 7.00
CHEMBL1774040
pIC50 7.02
CHEMBL1269258
pIC50 7.03
CHEMBL2017829
pIC50 7.03
CHEMBL91986
pIC50 7.05
CHEMBL88545
pIC50 7.06
CHEMBL2017834
pIC50 7.06
CHEMBL2017826
pIC50 7.10
CHEMBL570163
pKi 7.10
CHEMBL108130
pIC50 7.10
CHEMBL584063
pKi 7.10
CHEMBL570521
pKi 7.10
CHEMBL320141
pKi 7.10
CHEMBL95200
pKi 7.10
CHEMBL566359
pKi 7.10
CHEMBL88239
pIC50 7.12
| PMID | Text |
|---|---|
| 26608796 | The neurotransmitter cholecystokinin (CCK), along with its receptors, CCKAR and CCKBR, have been previously associated with psychiatric disorders, suggesting that variants near these genes may play a role in the pre-pulse/startle response in this cohort |
| 26551933 | CCK-AR polymorphism is protective against functional dyspepsia. |
| 25875176 | There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. |
| 25025063 | Age related differential expression of CCKAR in GBC may suggest two possible variants of the disease in this endemic belt. |
| 24914377 | CCK binding modulates the contractile function of the lower esophageal sphincter through differential binding to the CCK-A receptor on the sling and clasp fibers |
| 24825903 | Y140A mutation within a cholesterol-binding motif results in ligand binding and activity characteristics similar to wild type CCK1R. in a high cholesterol environment |
| 23701593 | The findings suggest that variants in the CCKAR gene may influence the risk of gallbladder cancer in women. |
| 23341962 | A significant association of the cholecystokinin-A receptor (CCKAR) gene variation rs1800857 and language lateralization, is reported. |
| 22825913 | The results showed that three individual haplotypes of CCKAR were strongly associated with increased risk of schizophrenia. |
| 22396142 | Data suggest that CCK-1R expression is up-regulated in kidney tubules (but not in glomeruli) in patients with diabetic nephropathy; increased expression of CCK-1R in tubules appears to be biomarker of severity of proteinuria in these patients. |
| More... |
MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNK 1 - 70 RMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERY 71 - 140 GAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWH 141 - 210 TFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKL 211 - 280 ELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGT 281 - 350 PISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH 351 - 420 MSASVPPQ 421 - 428 //
| PMID | Year | Title |
|---|---|---|
| 26608796 | 2015 | Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort. |
| 26551933 | 2016 | Functional dyspepsia is associated with GN?3 C825T and CCK-AR T/C polymorphism. |
| 25875176 | 2015 | Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. |
| 25025063 | 2014 | Differential expression of cholecystokinin A receptor in gallbladder cancer in the young and elderly suggests two subsets of the same disease? |
| 24914377 | 2014 | Investigation of cholecystokinin receptors in the human lower esophageal sphincter. |
| 24825903 | 2014 | A type 1 cholecystokinin receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment. |
| 23701593 | 2013 | Variants in CCK and CCKAR genes to susceptibility to biliary tract cancers and stones: a population-based study in Shanghai, China. |
| 23341962 | 2013 | Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization. |
| 22825913 | 2012 | Investigation of allelic heterogeneity of the CCK-A receptor gene in paranoid schizophrenia. |
| 22396142 | 2012 | Expression of cholecystokinin-1 receptor is correlated with proteinuria in human diabetic nephropathy. |
| More... |
