Protein Summary
Key enzyme in the regulation of glycerol uptake and metabolism. The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
- ENST00000378943
- ENSP00000368226
- ENSG00000198814
- ENST00000378945
- ENSP00000368228
- ENST00000378946
- ENSP00000368229
- ENST00000427190
- ENSP00000401720
- GK1
- GKD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.9 | ||
cellular component | 0.77 | ||
PubMedID | 0.76 | ||
gene perturbation | 0.75 | ||
transcription factor | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 156.65 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 304 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 156.65 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 304 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0