Property Summary

NCBI Gene PubMed Count 185
PubMed Score 102.38
PubTator Score 30.31

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
juvenile dermatomyositis 1189 9.81061355664892E-11
osteosarcoma 7933 3.09158733916178E-7
atypical teratoid / rhabdoid tumor 4369 1.30372897078909E-6
ovarian cancer 8492 2.33030979111401E-6
lung adenocarcinoma 2714 7.85322901812259E-6
medulloblastoma 1524 1.94155076637841E-5
medulloblastoma, large-cell 6234 2.17204376714034E-5
adult high grade glioma 2148 6.86605419876773E-4
diabetes mellitus 1663 0.0013946424680846
glioblastoma 5572 0.00203248304584496
limb girdle muscular dystrophy 2I 56 0.0029535886995472
dermatomyositis 967 0.0035063465010643
primary pancreatic ductal adenocarcinoma 1271 0.00373728994958078
colon cancer 1475 0.0147257847206525
Waldenstrons macroglobulinemia 765 0.0149990989349873
intraductal papillary-mucinous adenoma (IPMA) 2956 0.018689430142797
astrocytic glioma 2241 0.0209361271361809
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0266083678381181
pancreatic cancer 2300 0.0399752618405037
Parkinson's disease 364 0.0434825113992881
Disease Target Count Z-score Confidence
Eosinophilic meningitis 4 3.317 1.7
Cancer 2346 3.173 1.6
Prion disease 10 3.161 1.6



Accession P31946 A8K9K2 E1P616
Symbols HS1


PANTHER Protein Class (1)


2BQ0   2C23   4DNK  

  Ortholog (16)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG
C. elegans OMA Inparanoid
Fruitfly OMA Inparanoid

Gene RIF (53)

26730736 Data show that 14-3-3beta protein augmented the expression of matrix metalloproteinasea MMP2 and MMP9 through PI3 kinase/Akt protein/NF-kappaappa B pathway, thereby enhancing the invasiveness of hepatocellular carcinoma (HCC) cells.
26260846 These findings indicate that 14-3-3beta and gamma are novel PPARgamma2 regulators and are involved in hepatic lipid metabolism. 14-3-3b and gamma can be therapeutic target molecules to treat non-alcoholic fatty liver disease.
25228695 miR-152 controls both the expression of 14-3-3beta and HLA-G and exerts a dual role in tumor cells by both altering the immunogenicity and the tumorigenicity
24636949 Crystal structure of Myo1c/14-3-3beta complex, which has been implicated in the exocytosis of glucose transporter 4 storage vesicles during insulin-stimulated glucose uptake.
24555778 Data suggest that serum 14-3-3beta concentrations may constitute a useful marker for blood brain barrier damage severity and follow up in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis.
24269229 Data identified three classes of 14-3-3 targets that all have two binding sites, but displayed synergistic interaction between converging signalling pathways for different ranges of parameter values.
24038028 Using gene reporter assays, we show that promoter variations in 11 intrinsic apoptosis genes, including ADPRT, APAF1, BCL2, BAD, BID, MCL1, BIRC4, BCL2L1, ENDOG, YWHAB, and YWHAQ, influence promoter activity in an allele-specific manner.
23053962 These results indicate that the six YWHAB polymorphisms are not associated with the genetic susceptibility to sporadic Creutzfeldt-Jakob disease.
22278744 14-3-3beta binding to phosphorylated CFTR augments its biogenesis by reducing retrograde retrieval of CFTR to the endoplasmic reticulum. This mechanism permits cAMP/PKA stimulation to make more CFTR available for anion secretion.
22190034 HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells

AA Sequence

ESYKDSTLIMQLLRDNLTLWTSENQGDEGDAGEGEN                                      211 - 246

Text Mined References (202)

PMID Year Title
26730736 2016 14-3-3? Promotes Migration and Invasion of Human Hepatocellular Carcinoma Cells by Modulating Expression of MMP2 and MMP9 through PI3K/Akt/NF-?B Pathway.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26260846 2015 14-3-3? and ? differentially regulate peroxisome proliferator activated receptor ?2 transactivation and hepatic lipid metabolism.
26047703 2015 Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25852190 2015 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
25468996 2014 E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
25228695 2014 Identification of 14-3-3? gene as a novel miR-152 target using a proteome-based approach.
24947832 2014 Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.
24636949 2014 Crystal structure of human myosin 1c--the motor in GLUT4 exocytosis: implications for Ca2+ regulation and 14-3-3 binding.